Browsing by Title
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Jaklin, Sara Holthe (Master thesis; Mastergradsoppgave, 04-May-2009)[+][-]
Abstract: Oppgaven omhandler emnet preventiv nødverge, hvor fokuset er på den tidsmessige avgrensningen av nødvergesituasjonen. Problemstillingen er hvor lang tid i forkant av et angrep man har lovlig rett til å forsvare seg etter straffeloven § 48. URI: http://hdl.handle.net/10037/1915 File(s) in this item: 1
thesis.pdf (250.1Kb) -
Ulleland, Petter (Master thesis; Mastergradsoppgave, Nov-2008)[+][-]
Abstract: Hvordan kontinentalsokkelen i de norske nærområdene har blitt lagt inn under norsk jurisdiksjon siden introduksjonen av den moderne havretten i 1982. Bakgrunn, prosess og aktører. URI: http://hdl.handle.net/10037/1741 File(s) in this item: 1
thesis.pdf (1.769Mb) -
Mikkelsen, Tone (Master thesis; Mastergradsoppgave, Nov-2007)[+][-]
Abstract: Temaet for masteroppgaven er den voksne heltidsstudentens vilkår for læring. Hensikten med studien er å få innsikt i og kunnskap om heltidsstudentens studiesituasjon, dvs. hvordan heltidsstudenten erfarer og opplever en studietilværelse når en samtidig har familie og barn. Forståelse av den helheten som utgjør heltidsstudentens studiehverdag er altså i fokus. Bronfenbrenners økologiske systemteori (1979) danner bakgrunn for og gir begrunnelse for hvorfor det er nødvendig å se på heltidsstudentens studiesituasjon ut i fra et helhetsperspektiv. For å få innsikt i hvordan hverdagslivet med familie og studier kan fortone seg, har jeg i oppgaven presentert sentrale studier rundt temaet studier og hverdagsliv, alle knyttet til deltidsstudenten. I studien har jeg benyttet en kvalitativ tilnærming, nærmere bestemt det semi-strukturerte forskningsintervjuet. Jeg har intervjuet fire kvinner og to menn i alderen 30 år eller eldre ved profesjonsstudiene i juss, medisin og psykologi. Alle lever sammen med partner og barn og arbeider ved siden av studiene. Hva viser så studien? Heltidsstudentene i denne studien har en hverdag som på mange måter ligner deltidsstudentens hverdag. De må alle i ulik grad forholde seg til tre arenaer: studier, familie og arbeid. Familie og arbeid påvirker hvor og når de arbeider med studiene. Familiehensyn, studienes omfang, eksamenstider og tap av studietid på dagtid pga. arbeid er viktige grunner til at informantene benytter kvelder og helger til studier. Dette berører dermed fellestida med familien. Familien berøres også av studiene ved at familieøkonomien blir dårligere. Informantene vektlegger mental og praktisk støtte fra familien. Heltidsstudentens hverdag er håndterlig så lenge de kun har studier og familie å forholde seg til. En viktig forutsetning er imidlertid at det ikke skjer noe uforutsett i familien. Det er kombinasjonen av studier, familie og arbeid som i større grad skaper stress og press i hverdagen. Til sist viser studien at individets kapasitet eller evne til å støtte seg selv er en viktig forutsetning ved å være voksen heltidsstudent. Studien viser at heltidsstudenten må evne å regulere ikke bare studiekontekst, men også familie og arbeid. Det handler om å være selvstendig i studiesituasjonen, ha selvdisiplin og være bevisst på hvordan en utnytter tida. Samtidig må heltidsstudenten evne å tilpasse studiene slik at de på samme tid ivaretar forpliktelser i forhold til familie og arbeid. URI: http://hdl.handle.net/10037/1341 File(s) in this item: 1
thesis.pdf (228.3Kb) -
Fredriksen, Lill Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2008)[+][-]
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Wang, Catharina Elisabeth (Doctoral thesis; Doktorgradsavhandling, 13-Oct-2006)[+][-]
Abstract: The overall aim of the present study was to investigate how cognitive processing of emotionally valenced information may be a vulnerability factor to depression, and to develop a cognitive model of recurrent depression. Several more specific aims were formulated and investigated. To reach the aims of the study, an extensive theoretical review of the research literature on cognitive processes of depression was carried out. Also, we compared never depressed (ND; n = 46), previously depressed (PD; n = 42) and clinically depressed (CD; n = 61) individuals on several questionnaires and experimental tasks including dysphoric symptoms (BDI; Beck et al., 1979), dysfunctional attitudes (DAS; Weissman & Beck, 1978), preferences for positive and negative tape-recorded self-statements (Crowson & Cromwell, 1995), choice preference and reaction time to emotionally valenced words (DOAT; Gotlib, McLachlan, & Katz, 1988; Kakolewski, Crowson, Sewell, & Cromwell, 1999; McCabe & Gotlib, 1995), and free recall, recognition and fabrication of positive and negative self-statements (Wang & Holte, 1995). The main results of the study was: (1) the development of a Cognitive battle model to explain mechanisms involved in recurrent depression; (2) results which seem to indicate that dysfunctional attitudes, in mildly to moderately clinically depressed individuals, may have the potential to decrease the effortful processing of positive stimuli; and, (3) results which indicate that decreased approach motivation to positive stimuli may be a vulnerability factor to depression. Future research should be aimed to examine the relationship between parenting (e.g. insecure attachment; inadequate affect regulation), frontal lobe development (i.e., hemispheric asymmetry), cognitive vulnerability factors (e.g. uncertainty; rumination), and decreased approach motivation to positive stimuli. URI: http://hdl.handle.net/10037/660 File(s) in this item: 4
paper_I.pdf (222.3Kb)paper_II.pdf (222.4Kb)paper_III.pdf (342.4Kb)thesis.pdf (418.2Kb) -
Smetkin, Alexey Anatolievich; Kuzkov, Vsevolod; Gaidukov, Konstantin M; Bjertnaes, Lars J.; Kirov, Mikhail (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)[+][-]
Abstract: A recruitment maneuver (RM) may improve gas exchange in acute lung injury (ALI). The aim of our study was to assess the predictive value of a derecruitment test in relation to RM and to evaluate the efficacy of RM combined with surfactant instillation in patients with ALI. Materials and Methods. Thirteen adult mechanically ventilated patients with ALI were enrolled into a prospective pilot study. The patients received protective ventilation and underwent RM followed by a derecruitment test. After a repeat RM, bovine surfactant (surfactant group, n = 6) or vehicle only (conventional therapy group, n = 7) was instilled endobronchially. We registered respiratory and hemodynamic parameters, including extravascular lung water index (EVLWI). The derecruitment test decreased the oxygenation in 62% of the patients. We found no significant correlation between the responses to the RM and to the derecruitment tests. The baseline EVLWI correlated with changes in SpO2 following the derecruitment test. The surfactant did not affect gas exchange and lung mechanics but increased EVLWI at 24 and 32 hrs. Our study demonstrated no predictive value of the derecruitment test regarding the effects of RM. Surfactant instillation was not superior to conventional therapy and might even promote pulmonary edema in ALI. URI: http://hdl.handle.net/10037/4928 File(s) in this item: 1
article.pdf (498.1Kb) -
Buchanan, Charles Harley (Master thesis; Mastergradsoppgave, 04-Jun-2007)[+][-]
Abstract: The present thesis sets out to address explicanda which appeal to a notion of gaps vis-à-vis inflexional paradigms and further pose a challenge of modelling within contemporary generative phonology. Albright (2006) discerns phonotactically-motivated and lexically-arbitrary paradigm gaps. The former case serves as a repair strategy mandating circumvention of a surface-illicit configuration (i.e., ill-formedness); whereas the latter case sees the emergence of gaps alongside structurally analogous forms wherein no such gaps occur. Enquiry into the aforementioned phenomena will draw empirically on Swedish -ddt clustering and Icelandic imperative formation, respectively. A generalised phonological account will be pursued ad rem in the Swedish case study such that constraints relativised to morphosyntactic properties will be argued as conceptually inferior to the purely phonological model of grammar put forth. Upon analysis of Icelandic imperative formation, an approach appealing stringently to phonological properties will prove infeasible in light of data neutralising any such phonological triggers; requiring rather lexicalisation and the utility of a transderivational constraint, as incited by the uniformity effects of paradigm levelling. The cogency of these analyses will further suggest that analytic disparities distinguishing between Swedish and Icelandic gaps are irreconcilable in that the systematicities driving phonotactically-motivated and lexically-arbitrary paradigm gaps are markedly at odds. URI: http://hdl.handle.net/10037/1198 File(s) in this item: 1
thesis.pdf (673.8Kb) -
Hvalryg, Marte Monsen (Master thesis; Mastergradsoppgave, 16-Jun-2010)[+][-]
Abstract: I denne oppgaven har jeg sett nærmere på Drammen og Bodø sine omdømmeprosjekt. Jeg har beskrevet hva som kjennetegner de to byenes selvskildringer, for å se hvorvidt de framstår som like eller unike, og foklart variasjonene i presentasjonene. Jeg har valgt å karakterisere de to omdømmeprosjektene som en reformidé, da det er stadig flere steder som på ulike vis benytter seg av omdømmebygging som et strategisk grep for å vise seg fram i konkurrerende omgivelser preget av store mengder inntrykk og informasjon. Utgangspunktet for formuleringen av problemstillingen lå i en antakelse om at denne økende iverksettelsen av omdømmeprosjekt også vil innebære en homogenisering av måten man kommuniserer på og hva man forteller om stedene. URI: http://hdl.handle.net/10037/2713 File(s) in this item: 1
thesis.pdf (644.7Kb) -
Colindres, Clarence Oliver Gonzales (Master thesis; Mastergradsoppgave, 13-Jun-2006)[+][-]
Abstract: Fishing continues to be the main source of income in the Pearl Lagoon Basin in Nicaragua. Currently the fishermen in the area have expressed growing concern about the shrimps stocks. Over the past years it has become increasingly clear that the fish and shrimp stocks are being exhausted, severely over-fished and experiencing a serious decline. This thesis examines the catch compositions (shrimps and by-catch) of three mesh sizes of the Cast net gear employed in the fishery through sampling during the months of July and August, as well as analyzes the current situation of the shrimp inside the lagoon through primary (interviews) and secondary (books, journals, articles, reports, etc.) data. The data samples of the experiment with the different mesh sizes identified in the thesis were analyzed using standard software applying a trouser trawl method to determine the selectivity curve. Single factor ANOVA tests were use to distinguish significant differences between lengths. Significant differences were also tested combining the three different mesh sizes applying the SPSS turkey multi comparison computer program model. The findings were discussed and compared with a previous selectivity study accomplished in the lagoon. The thesis concludes that gears with ½ inch mesh size were vulnerable to the species during these months by retaining low weight and smaller length shrimp compositions (70% of the capture is between 5 and 8 cm total length). 1 inch and 1½ inch mesh sizes showed a general improvement in the selective performance of the gear (approximately 90% of the captured shrimps were between 11 and 14 cm). The main secondary findings show that local people are employing small gear mesh sizes in the lagoon, especially those whose sustainability livelihoods are significantly threatened with very few opportunities of survival; most obvious those who live in the more remote areas. URI: http://hdl.handle.net/10037/313 File(s) in this item: 1
thesis.pdf (1.012Mb) -
Brekke, Mary; Germeten, Sidsel; Jensen, Øyvind Bråstad; Jenssen, Øyvind; Sjøvoll, Jarle (Book; Bok, 2007)[+][-]
Abstract: De gode resultatene av en sterkere vektlegging på en praksisorientert lærerutdanning representerer et betydelig utviklingspotensial for lærerutdanning generelt. Den desentraliserte utdanninga opplevdes som – og var – relevant og meningsfull for alle aktører. I NOKUT’s vurdering av den stasjonære allmennlærerutdanninga i 2006 gir studentene uttrykk for at praksisopplæringa forbereder dem for dårlig til yrket. Nyutdannede lærere hevder ofte at de får et ”praksissjokk” når de begynner som lærere. Da de første kullene innenfor desentralisert lærerutdanning ble uteksaminert, var det nettopp praksisrelevansen både studenter, veiledere, rektorer og skolesjefer trakk fram som styrken ved modellen. Kan dette ha noe med balansen mellom teori og praksis i utdanninga å gjøre? Forholdet mellom tid til teori og tid til praksis var i de første kullene ganske forskjellig i den etablerte lærerutdanninga sammenlignet med desentralisert utdanning. I den desentraliserte utdanninga var det tre ganger så mye tid avsatt til praksis. Dette var den store forskjellen på den nye og den etablerte lærerutdanninga. Denne boka handler om de mulighetene som ligger i et praksisforankret læringsmiljø. Erfaringer fra noen desentraliserte lærerutdanningstiltak formidles fra personer med ulike faglige ståsted. URI: http://hdl.handle.net/10037/3368 File(s) in this item: 1
book.pdf (3.824Mb) -
Grindstein, Torkil (Master thesis; Mastergradsoppgave, 15-Nov-2009)[+][-]
Abstract: This Master thesis covers the design and evaluation of a multimedia content provider service. The design is scalable, both by means of storage, bandwidth and user count. To make the system stand out compared to competitors, there has been added design elements like a recommendation engine and a user feedback system. The system has been named SCARF, which is an abbreviation for Scalable CAching layered Recommendation and Feedback powered system. In order to do the evaluation part of the thesis, we have implemented a simulator for the entire system, on which we have executed numerous test runs. URI: http://hdl.handle.net/10037/2368 File(s) in this item: 1
thesis.pdf (2.541Mb) -
Klemetsen, Øystein (Doctoral thesis; Doktorgradsavhandling, 01-Feb-2012)[+][-]
Abstract: The topic covered in this thesis is medical temperature measurement of subcutaneous parts of human tissue with use of microwave radiometry. Radiometry is a completely non-invasive, non-toxic and relatively inexpensive sensing modality. The radiometric technique is based on the measurement of electromagnetic noise power emitted by lossy materials. The method has explicit low investment costs and low technological complexity, but relatively low spatial resolution. Still the method can be useful for some dedicated medical applications. Fundamental radiometric theory and dielectrical properties of biological tissues are derived. The process to realize a miniaturized radiometer is going from active antenna configuration to a complete miniaturized radiometer and finally to a modular radiometer, that is used \textsl{in-vivo} on humans. Different radiometers were designed, simulated, built and tested on realistic human phantoms. \textit{In vivo} experiments were also conducted to verify the prototype radiometer and to test the ability to be used in tailored medical diagnostics. The primary application covered is temperature gradient measurement during microwave hyperthermia and in pediatric vesicouretaral reflux (VUR) detection. Hyperthermia is a therapeutic technique in which cancerous tissue is heated to 40-45$^\circ$C, inducing vascular and cellular changes that improve the therapeutic effectiveness when used in conjunction with chemotherapy or radiation therapy. VUR is abnormal flow of urine from the bladder back to the upper urinary tract. Another application where this radiometer can be of great interest is in breast cancer diagnostic. Breast cancer is a type of cancer that forms in tissues of the breast; usually in the ducts and lobules and can occur in both men and woman. We present results from radiometric measurement on human phantoms during a hyperthermia heating sequence. Experimental evidence shows that radiometry can be used for temperature quality assurance of the heated volume in depth. In VUR detection, the first step is to heat the bladder prior to detection of the reflux. We present results from measurements \textsl{in-vivo} with a water filled balloon in the human mouth, that mimics pediatric bladder heating. Results show that the radiometer can be used as the first step in the novel VUR detection. Radiometry antennas are one of the most critical components in a radiometer system. An elliptical printed circuit board antenna is designed and matched to the human body. Further, an antenna with suction, with use of negative pressure to mount the antenna onto the human body for improved radiometric performance, was also proposed and built. The simple and elegant solution for the coupling of the antenna with use of negative pressure, documents improved performance in estimating the true temperature as well as exhibiting smaller fluctuation in the radiometric signal. Description: Papers 1,3,4 and 5 of this thesis are not available in Munin:
1. Ø. Klemetsen, Y. Birkelund, and S. K. Jacobsen: 'Design of medical radiometer front-end for improved performance', Progress In Electromagnetics Research B (2011) Vol. 27, 289–306. Available at http://www.jpier.org/PIERB/pier.php?paper=10101204
3. Øystein Klemetsen and Svein Jacobsen: 'Improved Radiometric Performance Attained by an Elliptical Microwave Antenna With Suction', IEEE transactions on biomedical engineering (2012)59(1):263-271. Available at http://dx.doi.org/10.1109/TBME.2011.2172441
4. Yngve Birkelund, Øystein Klemetsen, Svein K. Jacobsen, Kavitha Arunachalam, Paolo Maccarini, and Paul R. Stauffer: 'Vesicoureteral Reflux in children : a phantom study of microwave heating and radiometric thermometry of pediatric bladder', IEEE transactions on biomedical engineering (2011)58(11):3269-3278. Available at http://dx.doi.org/10.1109/TBME.2011.2167148
5. Svein Jacobsen and Øystein Klemetsen: 'Improved detectability in medical microwave radio-thermometers as obtained by active antennas', IEEE transactions on biomedical engineering (2008)55(12):2778-2785. Available at http://dx.doi.org/10.1109/TBME.2008.2002156URI: http://hdl.handle.net/10037/3818 File(s) in this item: 2
paper_2.pdf (6.815Mb)thesis.pdf (6.930Mb) -
Mortensen, Magnus (Master thesis; Mastergradsoppgave, 05-Feb-2007)[+][-]
Abstract: In the recent years, the Web has undergone a tremendous growth regarding both content and users. This has lead to an information overload problem in which people are finding it increasingly difficult to locate the right information at the right time. Recommender systems have been developed to address this problem, by guiding users through the big ocean of information. Until now, recommender systems have been extensively used within e-commerce and communities where items like movies, music and articles are recommended. More recently, recommender systems have been deployed in online music players, recommending music that the users probably will like. This thesis will present the design, implementation, testing and evaluation of a recommender system within the music domain, where three different approaches for producing recommendations are utilized. Testing each approach is done by first conducting live user experiments and then measure recommender precision using offline analysis. Our results show that the functionality of the recommender system is satisfactory, and that recommender precision differs for the three filtering approaches. URI: http://hdl.handle.net/10037/762 File(s) in this item: 1
thesis.pdf (750.8Kb) -
Hanssen, Harald Sømnes (Master thesis; Mastergradsoppgave, 27-Jan-2008)[+][-]
Abstract: Argos is a middleware platform developed at the ArticBeans lab at the University of Tromsø. The purpose of Argos is to provide a personal application platform for custom services. In this thesis we look at how Bluetooth devices along with Argos can be combined to create an application for encouraging and motivating physical activity. Physical activity is steadily decreasing among the population. People are getting more and more unhealthy due to lack of exercise. Playing computer games or watching television is rather normal today, going outside for a walk is something people seldom do. If a person wants to break the habit of sitting still, he will struggle with breaking the habit and committing to the new lifestyle. A person might have a higher chance of success, if he has something to remind him to exercise at a certain time of the day. The most common reason for failing to break a habit, can be due to lack of reinforcement of the new lifestyle. Having a personal application which allows the person to control his exercise, and also lets him see how much he has achieved, might prove both motivating and encouraging to continue to be more active. URI: http://hdl.handle.net/10037/1411 File(s) in this item: 2
Thesis.pdf (825.7Kb)thesis.zip (33.16Mb) -
Ekvang, Espen (Master thesis; Mastergradsoppgave, 01-Jun-2007)[+][-]
Abstract: Everywhere we go we are overwhelmed with impressions and experiences making our day. Research has proven these to change over time, thus psychologists and experimenters in surveys are interested in what a person actually experienced at a particular point in time, referred to as immediate experience. Whether it was as a reaction to some event or just at specific times during the day, is determined by the purpose of the project. By allowing an experimenter to ask questions to a set of participants at predefined times and dates, the approach called Experience Sampling Method (ESM) aims at capturing user experiences. To be able to ask such questions participants are required to carry some kind of device running the actual survey. Since most people possesses a mobile phone, this can serve as an excellent host for ESM surveys. In this thesis we have studied the ESM approach, and the design and implementation of a prototype framework for creating, running and collecting results from surveys based on ESM will be presented. Several mobile operating systems and devices exist, hence an important concern in our work has been interoperability between different devices. To achieve this goal we have emphasised on expressing all information exchanged between a computer and a mobile device in eXtensible Markup Language (XML). From our work we have seen that the flexibility of the prototype makes the system not limited to psychological surveys only, but the approach can be used as a very powerful tool for example in market analysis. URI: http://hdl.handle.net/10037/1042 File(s) in this item: 2
CDROM.zip (66.00Mb)thesis.pdf (7.904Mb) -
Eliassen, Bent-Martin; Melhus, Marita; Kruse, Jack; Poppel, Birger; Broderstad, Ann Ragnhild (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)[+][-]
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Eriksen, Øystein (Master thesis; Mastergradsoppgave, 16-Jun-2008)[+][-]
Abstract: CXCR4 is a GPCR that by activation of its ligand CXCL12 is involved in the pathology of several diseases, examples being cancer and rheumatoid arthritis. It has also shown to play a crucial role for HIV-1 entry into T-cells and the development of AIDS. Several cyclopentapeptides (CPPs) based on the sequence D-Tyr-Arg-Arg-2-Nal-Gly of the lead compound FC131 have shown to have antagonistic activity. These CCPs are therefore targets for drug research. In this thesis a previously published 3-point pharmacophore for these CCPs is reproduced and a new 4-point pharmacophore is presented. Structural similarities of low-energy conformations of CPPs that fit these pharmacophores have been identified. A set of new conformational stabilized CPPs based on these findings have been designed and synthesized. A set of citrulline based analogs of FC131 have been synthesized as they will serve as probes to determine the nature of the Arg residues interaction with CXCR4 URI: http://hdl.handle.net/10037/1580 File(s) in this item: 1
thesis.pdf (2.189Mb) -
Rudge, Cibele V. C.; Calderon, Iracema M. P.; Dias, Adriano; Odland, Jon Øyvind; Rudge, Marilza V. C.; Lopes, Gerson P.; Barbosa, Angélica P.; Maestá, Izildinha (Journal article; Tidsskriftartikkel; Peer reviewed, 29-Jul-2009)[+][-]
Abstract: Background: A review of validated methods for assessing female sexual dysfunction and a review of male and female sexual dysfunction did not refer to any specific questionnaire for evaluating sexuality during pregnancy. A study was performed at the Obstetrics and Gynecology Department of Botucatu Medical School, São Paulo State University, Brazil to design and validate a pregnancy sexuality questionnaire, the Pregnancy Sexual Response Inventory (PSRI).
Methods: Women with a singleton pregnancy between 10 and 35 weeks of gestation were randomly recruited. There were five phases in the development of the PSRI: (1) item selection; (2) item development; (3) determination of internal consistency, reliability and convergence; (4) content validity; and (5) determination of inter-interviewer reliability. Internal consistency and reliability were evaluated using Cronbach's alpha. Inter-interviewer reliability was assessed by evaluating the responses of 18 academics at various institutions, using Kappa Index and Student t test.
Results: Good internal consistency and reliability were obtained (Cronbach's alpha coefficient = 0.79). Among the 18 academics, 13 totally agreed (K = 1.0), three partially agreed (K = 0.67) and two disagreed (K = 0.33) with the proposed questions. Comparisons of the mean PSRI domain scores made between the primary investigators and the other interviewers showed no significant differences in all domains (p > 0.05).
Conclusion: PSRI is a new validated instrument for evaluating sexuality and sexual activity and related health concerns during pregnancy.URI: http://hdl.handle.net/10037/2166 File(s) in this item: 1
article.pdf (200.3Kb) -
Ravuri, Ashok Babu (Master thesis; Mastergradsoppgave, 23-Sep-2010)[+][-]
Abstract: This Master thesis is based on an ongoing project work titled ―Context-Sensitive systems for mobile communication in hospitals‖ at Norwegian Centre for Integrated care and Telemedicine (NST), University Hospital of North Norway (UNN). The project group is working on context-sensitive communication in hospitals based on Ascom/trixbox experimental (ATE) platform. The ATE based protocol system designed/developed to manage mobile communication interruptions in hospitals presents a new context-sensitive communication system for hospitals. The intended ATE based mobile communication work is based on different context information, in this case it is location information. This Master thesis is intended to provide a motivation for researchers and developers to develop/implement a context-sensitive mobile communication in hospitals. URI: http://hdl.handle.net/10037/2969 File(s) in this item: 3
Master Thesis Work 111.enl (24Kb)SourceCode.zip (274.8Kb)thesis.pdf (3.184Mb) -
Aune, Jon Åge (Mastergradsoppgave; Master thesis, 20-May-2009)[+][-]
Abstract: SAMMENDRAG CXCR4 er en kjemokinreseptor som er involvert i en rekke biologiske prosesser i kroppen, blant annet angiogenese, neurogenese og dannelse av blodceller i embryostadiet. I voksne er CXCR4 funnet å være involvert i sykdommer som HIV, reumatoid artritt og kreft. I litteraturen finnes det potente CXCR4 antagonister (AMD3100, KRH1636, FC131) som har vist effekt mot HIV-1, reumatoid artritt og kreft. Cyklopentapeptidet FC131 er av de mest potente og har vist høy anti-HIV-1 aktivitet. FC131 inneholder to aminosyrer (Arg3 og 2-Nal4) som er helt avgjørende for antagonistisk aktivitet. I denne oppgaven har det blitt syntetisert analoger av FC131, der 2-Nal4 har blitt byttet ut med andre aromatiske aminosyrer for å studere struktur-aktivitets-sammenhengen. Valg av nye aminosyrer har basert seg på egenskaper til den aromatiske naftylgruppen i KRH1636 og FC131. URI: http://hdl.handle.net/10037/2176 File(s) in this item: 1
thesis.pdf (2.024Mb)
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