Browsing by Title
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Engesæter, Birgit Øvstebø; Engebråten, Olav; Flørenes, Vivi Ann; Mælandsmo, Gunhild (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)[+][-]
Abstract: Mapatumumab and lexatumumab (targeting death receptor 4 (DR4) and 5 (DR5), respectively) are agonistic TRAIL receptor antibodies that induce apoptosis in a wide range of cancer cells. The potency of mapatumumab and lexatumumab was assessed in mono therapy protocols, and the ability to sensitize for dacarbazine (DTIC) treatment was explored in ten different melanoma cell lines. Our data indicated that melanoma cell lines tend to be resistant to mapatumumab, most likely due to low expression of DR4, while a dose dependent response to lexatumumab was observed. Combining DTIC and lexatumumab induced an additive or synergistic effect on cell death in the various melanoma cell lines. The synergistic effect observed in the FEMX-1 cell line was related to enhanced cleavage of Bid in parallel with elevated expression of the pro-apoptotic proteins Bim, Bax and Bak. Furthermore, the anti-apoptotic proteins Bcl-XL, cIAP-1, XIAP and livin were down regulated. Cleavage of Bid and down regulation of cIAP-2 and livin were observed in vivo. Altogether, these data suggest a change in the balance between pro- and anti-apoptotic proteins favoring induction of apoptosis. In the more therapy resistant cell line, HHMS, no changes in the pro- and anti-apoptotic proteins were observed. FEMX-1 xenografts treated with DTIC and lexatumumab showed reduced growth and increased level of apoptosis compared to the control groups, providing arguments for further evaluation of this combination in melanoma patients. URI: http://hdl.handle.net/10037/4920 File(s) in this item: 1
article.pdf (1.861Mb) -
Stødle, Håkon (Book; Bok, Sep-2002)[+][-]
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Nilsen, Fredrik Stellander; Wien, Anders Hauge (Master thesis; Mastergradsoppgave, 05-Jun-2008)[+][-]
Abstract: Målet med denne studien var å få en forståelse for hva som driver kunder i Tromsø til å handle dagligvarer. Mer konkret gikk vår problemstilling ut på å identifisere motiver og følelser for dagligvareshopping, for deretter å bruke disse i en segmenteringsanalyse av dagligvarekunder. Studien tok utgangspunkt i sentrale motivasjonsteorier innen shopping. I et forsøk på å utvide den eksisterende teorien inkluderte vi følelser og stressreaksjoner i analysen av shoppingmotiver. I tillegg ble butikkattributter, shoppingtid, demografi, holdninger til butikk, og butikkvalg inkludert i studien, med den hensikt å beskrive kundesegmentene. Den praktiske undersøkelsen bygger på en survey av dagligvarekunder i Tromsø. Shoppingmotivene som ble funnet var: hedonistisk, rolle, verdi, bekvemmelig, funksjonelt og produktorientert. Resultat av segmenteringsanalysen viser at det eksisterer fire segmenter av dagligvarekunder: Apatiske bekvemmelighetskunder, moderate kunder, funksjonelle opplevelseskunder og totalopplevelseskunder. De to første segmentene ser på dagligvareshopping som en plikt, mens de to siste føler det kan være en fornøyelse. Våre funn vil kunne bidra til utvikling av markedsstrategier innen dagligvarebransjen. URI: http://hdl.handle.net/10037/1558 File(s) in this item: 1
thesis.pdf (861.0Kb) -
Strøm, Jon Torger (Master thesis; Mastergradsoppgave, 15-May-2007)[+][-]
Abstract: Økt fokus på Corporate Governance i de siste årene har tvunget selskaper og myndigheter og andre interessenter til å se på hvordan det er mulig å oppnå det som er god Corporate Governance. Dette fokuset er kommet etter flere større skandaler i verden, skandaler av den proporsjon at de har klart å velte hele selskaper overende, dette er selskaper av som Enron, Parmelat og Finance Credit. Et av de viktigste områdene et selskap må ha fokus på for å oppnå god Corporate Governance er forholdet mellom daglig leder og styret. Denne oppgaven tar derfor for seg følgende problemstilling: Hva sier teorien om daglig leder, styret og om forholdet mellom dem? Og i hvor stor grad er rollene fortsatt blandet? Hvordan er fremtiden for norske styrer og daglige ledere? Trenger styret bransjeinnsikt for å være en støtte for daglig leder? I Norge har vi definert et klart skille for rollene, daglig leder og styret, i aksjeloven fra 1997. Der står det at rollen som daglig leder og styremedlem må være skilt fra hverandre om selskapet har over 3 millioner i aksjekapital. I Norge har det blitt satt sammen en gruppe (NUES) som skal se på norsk anbefaling for eierstyring og selskapsledelse. De kom med siste anbefaling 28. november 2006. Rollen som daglig leder, styremedlem eller i enkelte tilfeller begge blandet, er mye diskutert og studert. Rollene er forsøkt studert både fra et bedriftsøkonomisk perspektiv samt fra et psykologisk perspektiv. Noe som gir interessante synspunkter. I tillegg til å se på teori er det i denne oppgaven gjennomført en undersøkelse av disse rollene og sammenlignet med en annen tidligere undersøkelse som er gjort. Undersøkelsen er gjort for å kartlegge norske styrer og daglige lederes holdning til rollene daglig leder/styremedlem. Oppgaven har gjennom å vise til teori, erfaringer og undersøkelser avdekket at forholdet mellom daglig leder og styret er problemfylt. Men rollen har blitt klarere de siste årene, spesielt etter tankegangen rundt god Corporate Governance har bredt seg. Gjennom god Corporate Governance står bedriftene godt rustet til å møte de utfordringene som de står ovenfor i dag. URI: http://hdl.handle.net/10037/1024 File(s) in this item: 1
thesis.pdf (456.5Kb) -
Engeset, Dagrun; Hjartaker, A; Thoresen, Magne; Lund, Eiliv (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)[+][-]
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Andreassen, Tore Morten; Granados, Enrique; Andersen, Karsten (Book; Bok, 2005)[+][-]
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Haugland, Ole Anton (book; bok, 2007)[+][-]
Description: Kompendium for bruk av regneark og verktøy for formelredigering og enkel tegning i naturfag. Kompendiet tar for seg Excel 2003, men vil også passe for tidligere versjoner bakover til Excel 97. En nyere versjon (januar 2012) av dette kompendiet er tilgjengelig i Munin med følgende adresse: http://hdl.handle.net10037/3805 URI: http://hdl.handle.net/10037/2286 File(s) in this item: 1
book.pdf (510.2Kb) -
Ree, Håkon (Master thesis; Mastergradsoppgave, 05-Dec-2006)[+][-]
Abstract: Denne oppgaven tar for seg bruken av dativ i et utvalg diplomer fra den mellomnorske språkperioden. Diplomene er hentet fra Diplomatarium Norvegicum, som er den største samlingen med trykte kilder fra middelalderen. I undersøkelsen blir bruken av dativ i tekster fra det vikværske dialektområdet sammenliknet med tekster fra det opplandske dialektområdet. Man vet at dativ har holdt seg sterkere i områder på indre Østlandet enn ved kyststrøk. Oppgaven tar sikte på å finne ut om dette forholdet også gjelder i den mellomnorske perioden. Siden bøndene var de mest stedbundne og derfor kan gi best inntrykk av lokal talemåte, er det bondebrev som her blir undersøkt. I norrønt hadde dativformene flere bruksområder, og et sentralt aspekt ved undersøkelsen er å se på hvilke bruksområder dativ holder seg lengst ved. Hvordan dativ holder seg i ulike ordklasser, blir også undersøkt. URI: http://hdl.handle.net/10037/449 File(s) in this item: 1
thesis.pdf (2.023Mb) -
Angell, Synnøve (Master thesis; Mastergradsoppgave, 20-May-2009)[+][-]
Abstract: This thesis focuses on the significance of Sámi and indigenous vocal and musical expression in ethno and indigenous political mobilizing in the 1970s and particularly in June 1979. My point of departure is the Davvi Šuvva festival; the first Sámi and international indigenous culture and music festival after the establishing of the World Council of Indigenous Peoples. It took place on a hill in a Sámi and Swedish/Finnish border village in the north of Sweden and in the middle of Sápmi. My research is based on the interviews with people who organized the festival, artists and audience as well as written contemporary sources, a film about the event and 16 authentic tapes of recordings of the concerts at Davvi Šuvva. The oral sources of eye and ear witnesses represent insider views and experiences and the contemporary written sources of attending news paper journalists and writers from other magazines represent both insider and outsider perspective. “Davvi Šuvva 1979” also documents the ethno political background of the festival and discusses various perspectives on collective identity. While powwow dance and traditional native chanting expressed First Nation and Cree Indian identity and Inuit identity was expressed by traditional drum dance and drum singing Davvi Šuvva also demonstrated how yoik conveyed various Sámi identities. My intention is to show how and why vocal and musical expressions had, and still have, a particular significance in oral indigenous cultures as a means of struggle. The conclusions reached are that manifestations of Sámi and indigenous cultural expression and resistance like the Davvi Šuvva festival contributed to pride, recovery, dignity and positive self awareness and that the festival as such strengthened Sámi identity and indigenous togetherness and belonging. URI: http://hdl.handle.net/10037/2059 File(s) in this item: 1
thesis.pdf (4.806Mb) -
Frantsvåg, Jan Erik (Conference object; Konferansebidrag, 2006)[+][-]
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Stave, Torstein (Master thesis; Mastergradsoppgave, 01-Nov-2012)[+][-]
Abstract: På 1500- og 1600-tallet bredte det seg en storstilt trolldomsforfølgelse gjennom Europa. I overkant av 100 000 mennesker - majoriteten kvinner - ble formelt anklaget for å være trollfolk, og rundt 50 000 mistet livet på grunn av det. Norge var intet unntak og vi kjenner til minst 767 prosesser med 300 dødsfall til følge. Spesielt Finnmark ble hardt rammet, der hele 138 prosesser førte til 91 dødsfall. Med tanke på at det bodde knapt 3000 mennesker i Finnmark er dette ekstreme høye tall også i europeisk sammenheng. Bare de mest utsatte områdene i Tyskland og Frankrike kan skilte med så mange prosesser per innbygger. Finnmark skiller seg også ut i forhold til resten av landet i forhold til omfanget av demonologiske prosesser og elementer. Da Lucifer kom til Vardøhus undersøker omfanget av demonologisk tankegods i trolldomsprosessene i Finnmark og sammenligner funnene med Bergenhus len, Rogaland, Agder og Østlandet som totalt utgjør 660 av landets 767 trolldomsprosesser. Hovedproblemstillingen for oppgaven er todelt: I hvor stor grad skilte Vardøhus seg fra resten av landet, og hvorfor fikk demonologiske idéer bedre fotfeste i Vardøhus enn i resten av landet? Undersøkelsen avdekker blant annet 61 djevelpakter, 12 djevelmerker, 42 tilfeller av tortur og totalt 66 demonologiske prosesser i Vardøhus. Disse tallene er langt høyere enn alle de andre områdene, og utgjør hele 49,8 % av alle demonologiske prosesser i de utvalgte områdene. Årsaken til denne forskjellen er delvis på grunn av den uavklarte landegrensesituasjonen mellom Danmark/Norge, Sverige og Russland, forestillinger om det overnaturlige nord som Satans lekegrind blant den intellektuelle eliten og til slutt den skotske forbindelsen representert ved James VI og Vardøhus’ lensinnehaver John Cunningham. Spesielt John Cunningham må trekkes frem som avgjørende i hvert fall for introduksjon av demonologiske elementer til Finnmark. URI: http://hdl.handle.net/10037/4829 File(s) in this item: 1
thesis.pdf (910.0Kb) -
Zachariassen, Ketil (Master thesis; Mastergradsoppgave, 1998)[+][-]
Description: Dette er ei hovudfagsoppgåve URI: http://hdl.handle.net/10037/4163 File(s) in this item: 1
thesis.pdf (1.682Mb) -
Korankye, Thomas (Master thesis; Mastergradsoppgave, 15-May-2008)[+][-]
Abstract: The work examines the knowledgeability of fisher-folks as well as determines the extent to which their livelihood influences their susceptibility to HIV/AIDS infection. By making specific reference to fisher-folks at Elmina fishing community in the Central Province of the Republic of Ghana, it particularly challenges the hypothesis that fisher-folks are highly vulnerable to HIV/AIDS infection. The analysis thereof draws on elements from risk, social cognition and diffusion of innovation theories that are deemed useful in a study of HIV/AIDS. The study finds that although awareness level among the fisher-folks is high, their understanding and knowledge of the facts of the epidemic are significantly low. It therefore argues that the prevailing knowledge gap could cause many of the fisher-folks to become victims of the epidemic. Also, irrespective of the fact that the Ministry of Fisheries has a direct oversight responsibility over the fisheries sector in Ghana, it has neither incorporated nor prioritized the fight against the spread of HIV/AIDS in its policy and programs. The study reveals that wide spread of the disease among fisher-folks could significantly deprive the country of fish food as a result of lost of fishers’ lives. It could also exacerbate poverty among the fisher-folks owing to increased outflow of funds and reduced funds inflow. As a result of the non-triviality of the epidemic to Ghana’s fisheries, this work calls for the development of new institutional structures that make it plausible to integrate the issue of HIV/AIDS in managing Ghana’s fisheries. Finally, the study ascertains that the culture of risk denial does not extend to other dimensions of the lives of fisher-folks at Elmina. They are risk lovers owing to the risky, mobility and hard nature of their job. However, they are risk averse in terms of their social life style. Being risk averse, the study further argues that the fisher-folks at Elmina are highly likely to adopt a positive behavioral change. More so, it becomes easier to reach them with HIV/AIDS preventive measures. As Rosenstock (1974) - one of the health belief model proponents - asserts, people who see themselves to be at risk of contracting diseases are most often than not likely to accept a preventative action. URI: http://hdl.handle.net/10037/1429 File(s) in this item: 1
thesis.pdf (917.7Kb) -
Talseth, Anne-Grethe; Sørensen Høifødt, Tordis (Journal article; Tidsskriftartikkel; Peer reviewed, 23-Aug-2006)[+][-]
Abstract: Background: Suicide is a major public health problem and treating suicidal patients represents one of the most challenging and complex clinical situations for young physicians. Education of physicians is considered an important strategy in suicide prevention. Young physicians often meet suicidal patients early in their career. Limited information is available about how newly educated physicians experience treating suicidal patients. The aim of the study was to shed light on the meaning of newly educated physicians' lived experiences in treating patients at risk of committing suicide. Methods: Thirteen newly educated physicians narrated their experiences with suicidal patients. The interview text was transcribed and interpreted using a phenomenological-hermeneutical method inspired by Ricoeur's philosophy. Results: Three main themes and ten themes were noted: Striving for relatedness: relating with the patient; not being able to relate with the patient; Intervening competently: having adequate professional knowledge; performing professionally; having professional values; evaluating one's own competence; and Being emotionally involved: accepting one's own vulnerability; feeling morally indignant; feeling powerless and accepting one's own fallibility. The recently educated physicians clearly described the variety of emotional and ethical dilemmas that arose in meeting suicidal patients and the professional challenge facing this clinical situation. The findings were interpreted in the perspective of communication, clinical decision-making and attention to the professional's emotional reactions. Conclusion: An examination of the experiences of young physicians treating suicidal patients reveals three main themes that were a professional challenge for them: Striving for relatedness, Intervening competently and Being emotionally involved. Support for young practitioners that are treating these patients is likely important both to facilitate learning and also for their own wellbeing. This increased understanding can open up for the patient's suffering and affirm the patient's sense of life. The study provides additional background for educators designing training programs for physicians who will be treating suicidal patients. URI: http://hdl.handle.net/10037/1108 File(s) in this item: 1
article.pdf (272.1Kb) -
Høifødt, Tordis Sørensen; Talseth, Anne-Grethe (Journal article; Tidsskriftartikkel; Peer reviewed, 2006)[+][-]
Abstract: Abstract Background Suicide is a major public health problem and treating suicidal patients represents one of the most challenging and complex clinical situations for young physicians. Education of physicians is considered an important strategy in suicide prevention. Young physicians often meet suicidal patients early in their career. Limited information is available about how newly educated physicians experience treating suicidal patients. The aim of the study was to shed light on the meaning of newly educated physicians´ lived experiences in treating patients at risk of committing suicide. Methods Thirteen newly educated physicians narrated their experiences with suicidal patients. The interview text was transcribed and interpreted using a phenomenological-hermeneutical method inspired by Ricoeur´s philosophy. Results Three main themes and ten themes were noted: Striving for relatedness: relating with the patient; not being able to relate with the patient; Intervening competently: having adequate professional knowledge; performing professionally; having professional values; evaluating one’s own competence; and Being emotionally involved: accepting one’s own vulnerability; feeling morally indignant; feeling powerless and accepting one’s own fallibility. The recently educated physicians clearly described the variety of emotional and ethical dilemmas that arose in meeting suicidal patients and the professional challenge facing this clinical situation. The findings were interpreted in the perspective of communication, clinical decision-making and attention to the professional’s emotional reactions. Conclusions An examination of the experiences of young physicians treating suicidal patients reveals three main themes that were a professional challenge for them: Striving for relatedness, Intervening competently and Being emotionally involved. Support for young practitioners that are treating these patients is likely important both to facilitate learning and also for their own well-being. This increased understanding can open up for the patient’s suffering and affirm the patient’s sense of life. The study provides additional background for educators designing training programs for physicians who will be treating suicidal patients. URI: http://hdl.handle.net/10037/3205 File(s) in this item: 1
article.pdf (272.1Kb) -
Rudmin, Floyd Webster (Journal article; Tidsskriftartikkel, 2006)[+][-]
Abstract: The acculturation paradigm of measuring assimilation, separation, integration and marginalization confuses dimensional and categorical conceptions of its constructs, fails to produce ipsative data from mutually exclusive scales, misoperationalizes marginalization as distress, mismeasures biculturalism using double-barreled questions instead of computing it from unicultural measures, and then tends to misinterpret and miscite this faulty science. Extensive published but widely uncited data cast doubt on claims that integration is preferred by minority groups or is beneficial for them. Such salient but unseen problems suggest that the community of acculturation researchers is biased and blinded by an ideology, probably the commendable ideology of liberalism, which advocates freedom of choice, tolerance, plurality, and redress of harm. Phenomenological observations that challenge the paradigm include the absence of studies of majority group acculturation, the well-replicated fact that minorities never prefer pure uniculturalism, the indistinctiveness of cultures, and the predominance of researchers, theory and data from similar Anglo-Saxon settler societies (USA, Australia, Canada). URI: http://hdl.handle.net/10037/1996 File(s) in this item: 1
article.pdf (801.1Kb) -
Mathisen, Audun (Master thesis; Mastergradsoppgave, 03-Sep-2012)[+][-]
Abstract: En masteroppgave som tar for seg læreplanreformen Kunnskapsløftet og så kalt K06 eller LK06. Debatten rundt Kunnskapsløftet, endringer i læreplanene, med et fokus på historiefaget i den videregående skole. Oppgaven handler om den offentlige politiske debatten som begynte på 2000-tallet. Etter norske elevers resultater i den internasjonale PISA-undersøkelsen ble det fra politisk hold ment at man trengte et løft i norsk skole. Norske elever presterte middels i lesing og matte- og naturfagsresultater. Dette i forholdt til andre land vi pleier å sammenligne oss med. Daværende utdanningsminister Kristin Clemet ble pådriver for Kunnskapsløftet som i 2006 ble det første læreplanen som omfattet både grunnskolen og den videregående skolen Jeg diskuterer i denne oppgaven hvordan den politiske debatten utspilte seg, i tillegg til debatten med fagmiljøene. Jeg bruker historiefaget på videregående skole som eksempel når jeg viser til de faglige endringene fra R94 (den forrige læreplanen i videregående skole) til K06. I den nye læreplanen var målet at kunnskap skulle få et løft blant norske elever. Et av de sentrale elementene i denne prosessen har vært fokuseringen på de fem grunnleggende ferdighetene som skal flettes inn i alle fag på alle trinn. Disse er at elevene skal kunne; lese, skrive, uttrykke seg muntlig, kunne regne og kunne benytte seg av digitale hjelpemidler. URI: http://hdl.handle.net/10037/4828 File(s) in this item: 1
thesis.pdf (962.0Kb) -
Bjorbekkmo, Svein; Olstad, Reidun; Sørgaard, Knut; Myklebust, Lars H.; Molvik, Stian; Nymann, Asle (Journal article; Tidsskriftartikkel; Peer reviewed, 18-May-2009)[+][-]
Abstract: Background: The VELO study is a comparative study of two Community Mental Health Centres (CMHC) in Northern Norway. The CMHCs are organized differently: one has no local inpatient unit, the other has three. Both CMHCs use the Central Mental Hospital situated rather far away for compulsory and other admissions, but one uses mainly local beds while the other uses only central hospital beds. In this part of the study the ward staffs level of competence and treatment philosophy in the CMHCs bed units are compared to Central Mental Hospital units. Differences may influence health service given, resulting in different treatment for similar patients from the two CMHCs.
Methods: 167 ward staff at Vesterålen CMHCs bed units and the Nordland Central Mental Hospital bed units answered two questionnaires on clinical practice: one with questions about education, work experience and clinical orientation; the other with questions about the philosophy and practice at the unit. An extended version of Community Program Philosophy Scale (CPPS) was used. Data were analyzed with descriptive statistics, non-parametric test and logistic regression.
Results: We found significant differences in several aspects of competence and treatment philosophy between local bed units and central bed units. CMHC staff are younger, have shorter work experience and a more generalised postgraduate education. CMHC emphasises family therapy and cooperation with GP, while Hospital staff emphasise diagnostic assessment, medication, long term treatment and handling aggression.
Conclusion: The implications of the differences found, and the possibility that these differences influence the treatment mode for patients with similar psychiatric problems from the two catchment areas, are discussed.URI: http://hdl.handle.net/10037/2192 File(s) in this item: 1
article.pdf (212.9Kb) -
Bjorbekkmo, Svein; Olstad, Reidun E.; Myklebust, Lars Henrik Ryther; Sørgaard, Knut; Molvik, Stian; Nymann, Asle (Journal article; Tidsskriftartikkel; Peer reviewed, 2009)[+][-]
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Nuel, G; Dumeaux, vanessa; Olsen, Karina Standahl; Børresen-Dale, Anne-Lise; Paulssen, Ruth H; Lund, Eiliv (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)[+][-]
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