| Abstract: | The thesis is an attempt to arrive at the cartography of the low thematic domain of the clause using data from various argument structure constructions in Polish. It assumes the existence of a universal functional sequence (cf. Cinque (1999)) and the theory of morphology where morphemes are lexically specified to spell out chunks of the universal sequence. Furthermore, functional vocabulary items are flexible in the sense that they can be inserted for different subsets of their lexical specification. Part I deals with Polish conjugation class markers (so-called Themes), where a typology of the latter is proposed: high Themes spell out a superset of the featural hierarchy spelled out by low Themes. Two domains sensitive to the type of Theme are discussed: (i) verbs displaying the reflexive clitic (i.e. reflexive, anticausative, prefix-induced, and Reflexiva Tantum) and (ii) the Impersonal construction in -NO/TO. The conclusion is that bare stem inchoatives (i.e. Polish low Theme stems or inchoatives in causativizing languages) should not be equated with anticausatives. More generally, the notion ’split intransitivity’ should be deconstructed, given a very fine-grained universal sequence. Part II focuses on another type of functional vocabulary items, so-called Event Separators (ES) - morphology occurring in various participial constructions, as well as nominalizations. The main tenet is that the constant negotiation of spell out options between two items with overlapping lexical specification (i.e. Theme and ES) results in a typology of participial or nominalizing constructions. Furthermore, an analysis of Impersonal -NO/TO is advanced, where an analogy to Germanic/Romance Perfect Tense is drawn. The specific algorithm of mapping assumed to hold between the verbal and nominal functional sequence derives semantic restrictions on external arguments (i.e. features on Silverstein’s Hierarchy, e.g. animate, human, pronoun, etc.), as well as different degrees of ’subjecthood’. |
| URI: | http://hdl.handle.net/10037/991 |
| Abstract: | Resymé Introduksjon: Radiofrekvensablasjon har blitt brukt som behandling mot supraventrikulære takykardier ved UNN siden 2004. Metoden går ut på at man via katetre plassert intrakardielt kartlegger utløsende fokus og/eller ledningsbaner som bidrar til å opprettholde arytmien. Ved å applisere radiofrekvensenergi over de ønskede områder kan man destruere substratet for arytmien. Jeg har gått gjennom journaler på pasienter som fikk radiofrekvensablasjonsbehandling i perioden 2004-2006, og vil i denne oppgaven se nærmere på suksess-, residiv og komplikasjonsrater. Metode: Man gikk gjennom journaler til pasienter som har fått behandling for anfallsvis atrieflutter, AV-nodal reentry takykardi og for Wolff-Parkinson White syndrom i perioden. Pasienter som fikk ablasjonsbehandling for andre årsaker ble ekskludert fra undersøkelsen. Man registrerte data som gikk på type arytmi, alder og kjønn, primær suksess ved inngrepet, eventuelt senere residiv, prosedyretid og komplikasjoner. Resultater: Materialet omfatter 150 pasienter som fikk utført ablasjonsbehandling i perioden. Arytmiene fordelte seg med AVNRT 49 % (74/150), atrieflutter 23 % (35/150), manifest WPW 13 % (19/150) og skjult WPW 15 % (22/150). For det totale materialet var suksessraten 92,0 % (138/150), residivraten hos de med primært vellykket resultat var 8,0 % (n = 11), og komplikasjonsraten 4,7 % (n = 7). Menn utgjorde 59 % av pasientmaterialet, gjennomsnittlig alder var 49 ± 15 år. Gjennomsnittlig prosedyretid var 127 ± 43 minutter. For AV-nodal reentry takykardi (n = 74) var primær suksessrate 97,3 % (72/74), med en residivrate på 5,6 % (4/74). For Wolff-Parkinson White syndrom (n = 41) var primær suksessrate 80,5 % (33/41) og residivraten var 3,0 % (1/41). For anfallsvis atrieflutter (n = 35) var primær suksessrate 94,3 % (33/35) og residivrate 18,2 % (6/35). Diskusjon / Konklusjon: Resultatene fra perioden 2004-2006 viser at radiofrekvensablasjon er en effektiv behandling for pasienter med atrieflutter, Wolff-Parkinson White syndrom og AV-nodal reentry takykardi. Det var relativt få alvorlige komplikasjoner til behandlingen. |
| URI: | http://hdl.handle.net/10037/1664 |
| Abstract: | A new scheme for detection of vesicoureteral reflux (VUR) in children has recently been proposed in the literature. The idea is to warm bladder urine via microwave exposure to at least fever temperatures and observe potential urine reflux from the bladder back to the kidney(s) by medical radiometry. As a preliminary step toward realization of this detection device, we present non-invasive temperature monitoring by use of microwave radiometry in adults to observe temperature dynamics in vivo of a water-filled balloon placed within the oral cavity. The relevance of the approach with respect to detection of VUR in children is motivated by comparing the oral cavity and cheek tissue with axial CT images of young children in the bladder region. Both anatomical locations reveal a triple-layered tissue structure consisting of skin–fat–muscle with a total thickness of about 8–10 mm. In order to mimic variations in urine temperature, the target balloon was flushed with water coupled to a heat exchanger, that was moved between water baths of different temperatures, to induce measurable temperature gradients. The applied radiometer has a center frequency of 3.5 GHz and provides a sensitivity (accuracy) of 0.03 °C for a data acquisition time of 2 s. Three different scenarios were tested and included observation through the cheek tissue with and without an intervening water bolus compartment present. In all cases, radiometric readings observed over a time span of 900 s were shown to be highly correlated (R ~ 0.93) with in situ temperatures obtained by fiberoptic probes. |
| URI: | http://hdl.handle.net/10037/5057 |
| Abstract: | Sustainable livelihood means to live with the close harmony without losing ecosystem both in economical, social, environmental and cultural elements. Or other ways we can say live without the degradation of economical, social, environmental and cultural elements of an indigenous group is sustainable livelihood. Radio has the strong role in the sustainable livelihood of indigenous people. Mother language is the most powerful instrument of preserving and developing our tangible and intangible heritage. Promoting the recognition and practice of mother language media, especially radio, has its distinctive role. Radio is the cheapest and easiest, strongest and personal medium that can be useful every moment of a person’s life, though he/she is at works. So the radio has an impact on the indigenous people’s sustainable livelihood. ‘Sal Gittal’ is one of the programme broadcast from Bangladesh Betar, Dhaka for the Garo people. Within last thirty years they have had enormous benefit like lyricists, singers, artists come from them, they could present their language and culture in the national radio, which gives them inspiration to protect and flourish their culture and heritage. On the other hand Rakhaing, has no radio programme of their own. So their language and culture has no significant development, even diminishing day by day. Some of the Rakhaing people are now trying to retrieve their language, culture and heritage. Study findings showed that the Rakhaing feel them excluded from the world; and only a single programme in radio can give them a feeling of being a member of the world. |
| URI: | http://hdl.handle.net/10037/156 |
| Abstract: | Avhandlingen henter sitt tema fra et videreutdanningsstudium i aksjonslæring som Universitetet i Tromsø på oppdrag fra tre svenske kommuner arrangerte for en gruppe svenske lærere. I dette studiet har Furu opptrådt som prosjektleder, lærer, veileder og aksjonsforsker. I aksjonsforskning er det et nært samarbeid mellom forsker og praktikere som kan betegnes som et forskende partnerskap. I avhandlingen skiller man mellom aksjonslæring som planlagt, systematiske endringsarbeid som lærerne og skolelederne gjør i sin skolehverdag og aksjonsforskning som det forskerne foretar seg når de forsker sammen med lærere og skoleledere i skolen. Studiet var lagt opp slik at lærerne skulle arbeide med og gjennomdrøfte problemer hentet fra deres eget praksisfelt. Det viste seg at de gjennom arbeidet med egne problemer tok til å engasjere seg så sterkt at Furu stiller spørsmål om hun har funnet ”en magisk kilde”. Det er dette spørsmålet som danner basis for avhandlingen, og det blir søkt og belyst ved å gjennomgå åtte av studentenes aksjonslæringsprosjekter, ved å intervjue de samme lærerne et år etter avsluttet utdanning, og ved å drøfte de funn som blir gjort i lys av relevant pedagogisk teori. Funnene er analysert i en kognitiv og en emosjonell kategori. I kapitlet med analyse av den kognitive kategorien er forholdet mellom lærerforskning og aksjonslæring drøftet. Funnene indikerer at lærerne har oppnådd en pedagogisk styrking som resultat av sin deltakelse i aksjonslæringsprosessen. Styrkingen var ikke bare var intellektuell, den innebar også utviklingen av et sterkt personlig engasjement. Hvordan skal dette forklares? For å besvare spørsmålet er ulike emosjonsteorier anvendt for å analysere lærernes svar. Som konklusjon på det lærerne har sagt i intervjuene, har Furu tatt i bruk metaforen ”rak lærerrygg” for å uttrykke at aksjonslæring evner å skape autonome og stolte lærere. |
| URI: | http://hdl.handle.net/10037/941 |
| Abstract: | Global change is expected to lead to range shifts of plant species. The ecological mechanisms underpinning these shifts are currently not well understood. Here, we compared ecological responses possibly underlying southern range contraction and northern range expansion of Empetrum nigrum, a key species in northern heathlands, which may be related to global change. We hypothesized a negative response to warming in the ‘south’ (i.e. the Netherlands) and a positive response at the northern range margin (the tundra on Svalbard). Open top chambers (OTCs) were used to simulate global warming. In the ‘south’, OTC warming caused enhanced shoot growth and growth rate, biomass increment, advanced phenology, larger and heavier berries of Empetrum, while its growing season was extended by 75 days. Under OTC warming co-occurring Calluna vulgaris also showed an increased growing season length (by 98 days) as well as increased shoot growth rate and biomass growth, plant cover and height. Still, we found no evidence for increased competitiveness relative to Empetrum. In the ‘north’, Empetrum responded with increased shoot and biomass growth, enhanced berry development and ripening to warming. These responses exceeded those of co-occurring Cassiope tetragona with the exception of its biomass response. The direct and indirect ecological responses found do not readily explain the observed northward retreat of Empetrum at the southern range margin. The direct ecological responses found at its northern range margin are, on the other hand, in line with the increased occurrences of this species on Svalbard. |
| URI: | http://hdl.handle.net/10037/5052 |
| Abstract: | Productive tundra plant communities composed of a variety of fast growing herbaceous and woody plants are likely to attract mammalian herbivores. Such vegetation is likely to respond to different-sized herbivores more rapidly than currently acknowledged from the tundra. Accentuated by currently changing populations of arctic mammals there is a need to understand impacts of different-sized herbivores on the dynamics of productive tundra plant communities. Here we assess the differential effects of ungulate (reindeer) and small rodent herbivores (voles and lemmings) on high productive tundra vegetation. A spatially extensive exclosure experiment was run for three years on river sediment plains along two river catchments in low-arctic Norway. The river catchments were similar in species pools but differed in species abundance composition of both plants and vertebrate herbivores. Biomass of forbs, deciduous shrubs and silica-poor grasses increased by 40–50% in response to release from herbivory, whereas biomass of silica-rich grasses decreased by 50–75%. Hence both additive and compensatory effects of small rodents and reindeer exclusion caused these significant changes in abundance composition of the plant communities. Changes were also rapid, evident after only one growing season, and are among the fastest and strongest ever documented in Arctic vegetation. The rate of changes indicates a tight link between the dynamics of productive tundra vegetation and both small and large herbivores. Responses were however not spatially consistent, being highly different between the catchments. We conclude that despite similar species pools, variation in plant species abundance and herbivore species dynamics give different prerequisites for change. |
| URI: | http://hdl.handle.net/10037/4097 |
| Abstract: | I denne studien har jeg undersøkt regnskapsmessig rapporteringspraksis om eksponering mot finansiell risiko innenfor den norske hvitfiskindustrien. Formålet med studien er å undersøke hvorvidt rapporteringen er i samsvar med gjeldene norsk lovgivning og god regnskapsskikk på området. Jeg har i tillegg sett på flere forhold som kan være med å påvirke regnskapspraksisen. Bakgrunnen for valg av temaet er at PwC opplyste i årsoppgjørsveiledningen for 2010 at mange foretak ikke følger kravene vedrørende rapportering av finansiell risiko som av regnskapsstandarden NRS (16) Årsberetning, punkt 2.7, fullt ut. For å besvare studiens problemstilling har jeg gjennomført en empirisk undersøkelse av den norske hvitfiskindustrien. Bakgrunnen for at jeg valgte hvitfiskindustrien som målpopulasjon er at jeg ønsket et ensartet utvalg, for å undersøke rapporteringspraksisen i en bransje som er svært eksponert mot finansiell risiko. Utgangspunktet for studien er regnskapsårene 2008 og 2009. For å understreke hvordan eksterne regnskapsbrukere i all hovedsak blir opplyst av foretakenes finansielle risiko ble det kun benyttet sekundærdata, i form av utvalgets årsrapporter, for å besvare avhandlingens problemstilling. Studien avdekker at de undersøkte foretakene i varierende grad oppfyller minimumskravene knyttet til rapportering av foretakets finansielle risiko i årsberetningen. Dette medfører en svekkelse av regnskapets informasjonsverdi for brukerne, og for brukerne som anvender regnskapene som beslutningsgrunnlag, kan konsekvensen av at informasjonsbehovet ikke blir tilfredsstilt føre til at beslutninger blir tatt på feil grunnlag. Nøkkelord: regnskapsrapportering, finansiell risiko, regnskapsmessig tilleggsopplysninger, årsberetning, noteopplysninger. |
| URI: | http://hdl.handle.net/10037/4457 |
| Abstract: | Formålet med denne utredningen er å avdekke hvordan hotellbransjen i dag rapporterer og arbeider med samfunnsansvar, og undersøke hvilken betydning det får for denne bransjen dersom det i regnskapsloven blir vedtatt en rapporteringsplikt om samfunnsansvar. |
| URI: | http://hdl.handle.net/10037/4466 |
| Abstract: | Denne rapporten oppsummerer prosjektet ”Spesialpedagogisk kompetanseutvikling Norge–-Nordvest-Russland 2002–2005”. Det er den avsluttende delen av et norsk-russisk samarbeid som har strukket seg over perioden 1998–2005. Prosjektet er grundig beskrevet i prosjektplanen som ble utarbeidet i sin endelige form i mars 2003 (vedlagt). Første del av samarbeidet, perioden 1998–2001, var organisert i prosjektet ”Spesialpedagogikk Ark-hangelsk”. Det er først beskrevet i prosjektplanen fra juli 1998 og oppsummert i prosjektrapporten som ble utarbeidet høsten 2001 (begge er vedlagt). |
| Description: | Høgskolen i Tromsø i samarbeid med Nord-Norges Diakonistiftelse, Fylkesmannen i Troms, Pomor-Universitetet i Arkhangelsk og Arkhangelsk fylke |
| URI: | http://hdl.handle.net/10037/2323 |
| Abstract: | Roman ”Raskol” skrevet av den moderne russiske forfatter Vladimir Lichutin. ”Raskol” - en historisk roman. Forfatteren forteller historien om kirkekampen i Moskovskaja Rus’ (Russland) . Dette førte til en splittelse i samfunnet. Mange progressive mennesker, forskere, forfattere og kunstnere ble interessert i denne viktige saken i de neste århundrene. Lichutin prøver å forstå splittelsen for å beskrive det virkelige bildet av hva som skjedde. For leseren er de viktigste historiske personlighetene fra denne tiden: Tsar Aleksej Mikhailovitsj, patriarken Nikon, erkeprest Avvakum, boyarynya Morozova. Forfatteren vurderer ideen: Moskva - det tredje Roma. Hva ble stillingen til Tsar Aleksej Mikhailovitsj og hans hoff? Hva var rollen til patriark Nikon i dette? Lichutin beskrev til oss motstandere av reformer i den russiske kirke. Mange kristne som var uenige med kirkens reform, forlot den offisielle kirken. Forfatteren skriver i detaljer om disse menneskene. Hva var deres grunn til uenighet? Lichutin utforsker også spørsmålet om de gammeltroende. Hvorfor så mange av dem dro til Sibir. Hvorfor ble det opprør i det kjente Solovki-klosteret, som var uenig med endringen i utførelsen av gudstjenester. Jeg ser også i mitt arbeid verker av andre forfattere som har skrevet om kirkesplittelsen og gammeltroende. I avslutningen av arbeidet mitt, oppsummerte jeg resultatene: hvordan splittelsen påvirket livet i det moderne samfunnet. Jeg henvendte meg til forfatteren Lichutin med intervju. |
| URI: | http://hdl.handle.net/10037/2991 |
| Abstract: | We consider a pie-splitting game involving three committee members. In response to the large literature on sequential procedures in this type of game, we propose an institution that is inspired by auction theory. The (sealed) bids of the players are proposals for a distribution of the pie and are given simultaneously. If any of the bids is preferred to all others in a pairwise comparison (i.e. a Condorcet winner exists) then this proposal is implemented. If such a bid does not exist then an equal split of the pie is assumed. An equilibrium of this game is for each player to suggest that one of the opponents should receive the lion’s share of the pie, even though each player cares only about his own share. We call this phenomenon “rational benevolence”. Although the end that is desired by the players is purely egoistic, the means of achieving it may be perceived as benevolent. Several applications of the game are suggested. |
| URI: | http://hdl.handle.net/10037/946 |
| Abstract: | The low density lipoprotein receptor-related protein-1 (LRP-1) is a large, multifunctional endocytic receptor from the LDL receptor family, highly expressed in liver parenchymal cells (PCs), neurons, activated astrocytes, and fibroblasts. The aim of the study was to investigate if liver sinusoidal endothelial cells (LSECs), highly specialized scavenger cells, express LRP-1. To address this question, experiments were performed in vivo and in vitro to determine if receptor associated protein (RAP) and trypsin-activated α2-macroglobulin (α2M∗) were endocytosed in LSECs. Both ligands were cleared from the circulation mainly by the liver. Hepatocellular distribution of intravenously administered ligands, assessed after magnetic bead cell separation using LSEC- and KC-specific antibodies, showed that PCs contained 93% and 82% of liver-associated 125I-RAP and 125I-α2M∗, whereas 5% and 11% were associated with LSECs. Uptake of RAP and α2M∗ in the different liver cell population in vitro was specific and followed by degradation. The uptake of 125I-RAP was not inhibited by ligands to known endocytosis receptors in LSECs, while uptake of 125I-α2M∗ was significantly inhibited by RAP, suggesting the involvement of LRP-1. Immunofluorescence using LRP-1 antibody showed positive staining in LSECs. Ligand blot analyses using total cell proteins and 125I-RAP followed by mass spectrometry further confirmed and identified LRP-1 in LSECs. LSECs express functional LRP-1. An important implication of our findings is that LSECs contribute to the rapid removal of blood borne ligands for LRP-1 and may thus play a role in lipid homeostasis. |
| Description: | This paper is part of Cristina Ionica Øie's doctoral thesis, which is available in Munin at http://hdl.handle.net/10037/2910 |
| URI: | http://hdl.handle.net/10037/4078 |
| Abstract: | Masteroppgaven tar for seg temaet regionalt differensiert arbeidsgiveravgift gjennom en komparativ analyse av RDA-ordningene DA Bodø og RDA Tromsøs tildelingspraksis. I Norge er det slik at arbeidsgivere betaler en avgift på lønnskostnader som bidrag til folketrygden. Denne avgiften er regionalt differensiert, noe som gjør den til et viktig og ubyråkratisk distriktspolitisk virkemiddel. I forbindelse med Norges medlemskap i EØS, påla i 2003 imidlertid EFTAS’ overvåkingsorgan ESA innskrenkninger i systemet med de differensierte avgiftssatsene. Resultatet ble imidlertid at det ble innført en ny ordning fra 2006, der mesteparten av landet fikk tilbake de avgiftssatsene som de hadde før 2003. Unntaket er Bodø i Nordland og Tromsø i Troms der det nå er en noe høyere avgiftssats enn tidligere. I disse byene er det opprettet ordningene DA Bodø og RDA Tromsø, som har den hensikt å tilbakeføre deler av de avgiftsinntektene som staten har fått på grunn av denne avgiftsøkningen tilbake til disse områdene. Dette i form av alternative, kompenserende tiltak som skal skape en bred næringsrettet innsats. Oppgaven fokuserer på tildelingspraksisen som preger disse ordningene, og hvordan vi kan forstå forskjeller mellom hvordan ordningene praktiseres. Dette med bakgrunn i iverksettingsteori, med fokuspunktene politisk og administrativ organisering, handlingsplan/handlingsprogram, og prosesser i og rundt beslutningsarenaene. |
| URI: | http://hdl.handle.net/10037/2881 |
| Abstract: | The subjects are a group of bilingual pupils in 3rd grade. They live in an area dominated by Norwegian, but their parents have chosen Sámi as their first language in school. The pupils communicate in Sámi with one or both parents, the teacher, classmates during lessons, and in some cases other family members. In play, both in their neighbourhood and school, the children use Norwegian. Earlier research has showed that bilingualism for some groups has a positive effect on education, for other a negative effect. The motivation for this study is to describe the language environment and the pupils' reading competence in the context described above. The most of the children manage decoding rather well, and the decoding mistakes are of the same types in both languages. There is a connection between decoding proficiency and understanding of the text, but this is complex. The reading comprehension for all the children was at least twice as good for Norwegian texts compared with Sámi texts, for some of the children more than three times better. There was a clear connection between the children's language environment and their comprehension of the texts from school books written for the class level. |
| URI: | http://hdl.handle.net/10037/2289 |
| Abstract: | The thesis reflects on how literature can provide new understandings in regards to how we conceive ourselves and the world. Further, it directs attention to the need to strengthen students’ response to the cognitive, emotional and aesthetic aspects of the literary text. This thesis suggests that literature can be used to address important social aspects which a class might encounter. I illustrated my claims through Zora Neale Hurston’s acclaimed Their Eyes Were Watching God. I connected issues of identity, race and gender roles from the text with students’ life. The intention is to provide a way of thinking about some important and recurring issues that most teachers will need to address. It examines broad teaching approaches as writing, discussions and visualizing responses. This thesis suggests that reading can be a means of developing intelligent awareness of race and gender issues in the students’ own lives. |
| URI: | http://hdl.handle.net/10037/4845 |
| Abstract: | This thesis attempts to use the theoretical concept of “place” borrowed from the humanistic geographers to explore, firstly, the differences between traditional and digital place making and secondly, the nature of digital documents in connection to digital environments.
When employing “place” as a theoretical concept, I argue that place making in digital dimensions is comparable to that in traditional ones. As a kind of cultivated environment, digital environments also function as “places” for modern humans. This is crucial to our daily existence since modern humans apparently rely extensively on digital technology. By seeing websites as “places”, the evolutionary nature of digital documents is reconfirmed. Instead of the paper-digital dichotomy, websites in this thesis are seen as an evolvement or a continuation of traditional documents. Also, digital environments open new possibilities for reading without replacing traditional modes of reading. The exploratory investigative mode of reading does not exclude preceding reading modes such as the isolated immersion mode. In addition, the two websites are examples of web documents and demonstrate the capability to connect with other documents via links and nodes. Navigational structures and also thematic and representational linkages make connections. By showing themselves as localities as well as part of interrelated networks, the two websites enable the flow between local and global. Last but not least, the relation between websites as “places” and the “imagined” communities is explored. I argue that the communities formed by these two non-interactive websites depend primarily on symbolic associations and the sharing of cultural meaning. This final observation brings us back to the findings on “place” and place making since the bonding between “place” and people is, as Yi-Fu Tuan has argued, fundamentally affective, associative and symbolic. These two case studies have illustrated the possibility that websites may be read as “places” and reading them as such provides us with insights into place making in digital environments. Further investigation into other kinds of websites such as interactive websites will be necessary to establish the essential criteria for the distinction between websites as “places” and websites as “sites”. Reading websites as “places” will thereby enhance our comprehension of digital environments that is of growing significance for modern human existence. |
| URI: | http://hdl.handle.net/10037/1775 |
| Abstract: | Real-time media rich applications rely on live streams of rich and accurate meta-data describing the video content to provide personal user experiences. Unfortunately, the general amount of video meta-data today is often limited to titles, synopsis and a few keywords. A wildly used approach for extraction of meta-data from video is computer vision. It has been developed a number of different video processing algorithms which can analyse and retrieve useful data from video. However, the computational cost of current computer vision algorithms is considerable. This thesis presents a software architecture that aims to enable real-time annotation of multiple live video streams. The architecture is intended for use within media rich applications where extraction of video semantics in real-time is necessary. Our conjecture was that staging video processing in levels will make room for a more scalable video annotation system. To evaluate our thesis we have developed the prototype runtime Árvdadus. Our experiments show that staged processing can decrease the computation time of meta-data extraction. The evaluation of the architecture suggests that the architecture is applicable in a wide range of domains where extraction of meta-data in real-time is necessary |
| URI: | http://hdl.handle.net/10037/3520 |
| Abstract: | Gonorrhea is a sexually transmitted disease caused by bacteria called gonococci. The disease was described in ancient times, but until the late nineteenth century it was mixed up with syphilis. Eventually microscopy could differ between the organisms and give a reliable diagnosis. Human is the only known reservoir for gonorrhea. It is transferred during all acts of sexual activity, and an infection cause characteristic symptoms if established. Reliable diagnostic tools are important not only because gonorrhea is a severe disease but also because the means of spreading will always have a negative social impact on people given the diagnosis. Gonococci are fastidious bacteria, and survive poorly outside its human host. Thus diagnostic methods have been challenged by the problem of retrieving living bacteria for phenotypic tests. There have been several attempts to identify gonococci by specific characteristic in its genome, but these have been less successful. Due to its fluctuating genome it has been difficult to find a specific target for the gonococci. Here I present an attempt to establish a reliable diagnostic tool for reproducible detection and specific identification of gonococci in samples from different body sites. |
| URI: | http://hdl.handle.net/10037/1601 |
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