English
norskInstitutt for farmasi
Bla i:
Nye registreringer
-
De novo sequencing of disulphide rich peptides using tandem mass spectrometry
(Master thesis; Mastergradsoppgave, 2015-05-13)Peptide based drugs have been shown to have better target selectivity and thereby better safety profile than many small molecule drug candidates. This led many researchers and drug companies to show an increasing interest ... -
Costs and benefits of natural transformation in Acinetobacter baylyi
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-15)Background <br> Natural transformation enables acquisition of adaptive traits and drives genome evolution in prokaryotes. Yet, the selective forces responsible for the evolution and maintenance of natural transformation ... -
Interplay of choline metabolites and genes in patient-derived breast cancer xenografts
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-01-21)Introduction: Dysregulated choline metabolism is a well-known feature of breast cancer, but the underlying mechanisms are not fully understood. In this study, the metabolomic and transcriptomic characteristics of a large ... -
Successful co-encapsulation of benzoyl peroxide and chloramphenicol in liposomes by a novel manufacturing method - dual asymmetric centrifugation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-16)Encapsulation of more than one active pharmaceutical ingredient into nanocarriers such as liposomes is an attractive approach to achieve a synergic drug effect and less complicated dosing schedules in ... -
The Potential of Cyclodextrins as Novel Active Pharmaceutical Ingredients: A Short Overview
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-25)Cyclodextrins (CDs) are cyclic oligosaccharides of natural origin that were discovered more than 100 years ago. The peculiar cone-like conformation of the sugar ring, expressing a lipophilic cavity and a hydrophilic ... -
No effect of natural transformation on the evolution of resistance to bacteriophages in the Acinetobacter baylyi model system.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016)The adaptive benefits of natural transformation, the active uptake of free DNA molecules from the environment followed by incorporation of this DNA into the genome, may be the improved response to selection resulting from ... -
The Role of Adherence and Retreatment in De Novo Emergence of MDR-TB
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016)Treatment failure after therapy of pulmonary tuberculosis (TB) infections is an important challenge, especially when it coincides with de novo emergence of multi-drug-resistant TB (MDR-TB). We seek to explore possible ... -
The Presumed Polyomavirus Viroporin VP4 of Simian Virus 40 or Human BK Polyomavirus Is Not Required for Viral Progeny Release
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-14)The minor capsid protein of human BK polyomavirus (BKPyV), VP2, and its N-terminally truncated form, VP3, are both important for viral entry. The closely related simian virus 40 (SV40) reportedly produces an additional ... -
Reconstruction of a nonlinear heat transfer law from uncomplete boundary data by means of infrared thermography
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-07)Heat exchange between a conducting plate and the environment is described here by means of an unknown nonlinear function F of the temperature u. In this paper we construct a method for recovering F by means of polynomial ... -
Fibroblast-induced switching to the mesenchymal-like phenotype and PI3K/mTOR signaling protects melanoma cells from BRAF inhibitors
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016)The knowledge on how tumor-associated stroma influences efficacy of anti-cancer therapy just started to emerge. Here we show that lung fibroblasts reduce melanoma sensitivity to the BRAF inhibitor (BRAFi) vemurafenib only ... -
Development and optimization of a new processing approach for manufacturing topical liposomes-in-hydrogel drug formulations by dual asymmetric centrifugation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-24)Objectives: The objective of the present study was to utilize dual asymmetric centrifugation (DAC) as a novel processing approach for the production of liposomes-in-hydrogel formulations. <br>Materials and Methods: Lipid ... -
Detection of disseminated tumor cells in lymph nodes from patients with early stage non-small cell lung cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-17)Background: The regional lymph node involvement is a major prognostic factor in patients with non-small cell lung cancer (NSCLC) undergoing surgical resection. Disease relapse is common, suggesting that early disseminat ... -
Prognostic significance of S100A4 expression in stage II and III colorectal cancer: results from a population-based series and a randomized phase III study on adjuvant chemotherapy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-08)Current clinical algorithms are unable to precisely predict which colorectal cancer patients would benefit from adjuvant chemotherapy, and there is a need for novel biomarkers to improve the selection of patients. The ... -
Steady at the wheel: Conservative sex and the benefits of bacterial transformation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-12)Many bacteria are highly sexual, but the reasons for their promiscuity remain obscure. Did bacterial sex evolve to maximize diversity and facilitate adaptation in a changing world, or does it instead help to retain the ... -
The isolated perfused human skin flap model: A missing link in skin penetration studies?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-05)Development of effective (trans)dermal drug delivery systems requires reliable skinmodels to evaluate skin drug penetration. The isolated perfused human skin flap remainsmetabolically active tissue for up to 6 h during ... -
Chitosan-Based Nanomedicine to Fight Genital Candida Infections: Chitosomes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017)Vaginal infections are associated with high recurrence, which is often due to a lack of efficient treatment of complex vaginal infections comprised of several types of pathogens, especially fungi and bacteria. Chitosan, a ... -
An audit and feedback intervention study increased adherence to antibiotic prescribing guidelines at a Norwegian hospital
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-27)Background:<br> Appropriate antibiotic prescribing is associated with favourable levels of antimicrobial resistance (AMR) and clinical outcomes. Most intervention studies on antibiotic prescribing originate from settings ... -
A sudden and unprecedented increase in low dose naltrexone (LDN) prescribing in Norway. Patient and prescriber characteristics, and dispense patterns. A drug utilization cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-26)Purpose: Following a TV documentary in 2013, there was a tremendous increase in low dose naltrexone (LDN) use in a wide range of unapproved indications in Norway. We aim to describe the extent of this sudden and unprecedented ... -
Substitutions of short heterologous DNA segments of intragenomic or extragenomic origins produce clustered genomic polymorphisms
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-27)In a screen for unexplained mutation events we identified a previously unrecognized mechanism generating clustered DNA polymorphisms such as microindels and cumulative SNPs. The mechanism, short-patch double illegitimate ... -
Prevalence of Different Combinations of Antiepileptic Drugs and CNS Drugs in Elderly Home Care Service and Nursing Home Patients in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06)Introduction. Antiepileptic drugs (AEDs) are used to treat different conditions in elderly patients and are among the drug classes most susceptible to be involved in drug-drug interactions (DDI). The aim of the study was ...
RSS 1.0