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Browsing Artikler, rapporter og annet (kjemi) by Title

Now showing items 1-20 of 27

2-Chloro-2-phenylethylammonium chloride

Lejon, Tore Sigvard; Ingebrigtsen, Truls Erik; Hansen, Lars Kr (Journal article; Tidsskriftartikkel; Peer reviewed, 2006)

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URI: http://hdl.handle.net/10037/3184

File(s) in this item: 1

article.pdf (103.1Kb)
3-(Acetylamino)benzoic acid

Hansen, Lars Kr; Perlovich, German; Bauer-Brandl, Annette (Journal article; Tidsskriftartikkel; Peer reviewed, 2007)

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URI: http://hdl.handle.net/10037/3175

File(s) in this item: 1

article.pdf (2.738Mb)
4-Hydroxybenzamide

Hansen, Lars Kr; Perlovich, German; Bauer-Brandl, Annette (Journal article; Tidsskriftartikkel; Peer reviewed, 2007)

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URI: http://hdl.handle.net/10037/3180

File(s) in this item: 1

article.pdf (2.798Mb)
7-Azathieno[2,3-c] cinnoline

Hansen, Lars Kr; Stockmann, V; Fiksdahl, A (Journal article; Tidsskriftartikkel; Peer reviewed, 2007)

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URI: http://hdl.handle.net/10037/3296

File(s) in this item: 1

article.pdf (571.6Kb)
7-azathieno[3,2-c]cinnoline

Hansen, Lars Kr; Stockmann, V; Fiksdahl, A (Journal article; Tidsskriftartikkel; Peer reviewed, 2007)

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URI: http://hdl.handle.net/10037/3179

File(s) in this item: 1

article.pdf (575.8Kb)

Antibiotikaresistent - hva nå?

Leiros, Hanna-Kirsti S. (Conference object; Konferansebidrag, 02-Sep-2010)

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Description: Innlegg på seminaret "Science - who cares?" ved NT-fak, Universitetet i Tromsø.

URI: http://hdl.handle.net/10037/2697

File(s) in this item: 1

article.pdf (2.376Mb)

Methyl 5-nitro-2-(phenylamino)pyridine-4-carboxylate

Hansen, Lars Kr; Tjosas, F; Tjosås, Freddy; Fiksdahl, A (Journal article; Tidsskriftartikkel; Peer reviewed, 2006)

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URI: http://hdl.handle.net/10037/3178

File(s) in this item: 1

article.pdf (174.8Kb)

N-(3-hydroxyphenyl)acetamide

Hansen, Lars Kr; Perlovich, German; Bauer-Brandl, Annette (Journal article; Tidsskriftartikkel; Peer reviewed, 2006)

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URI: http://hdl.handle.net/10037/3173

File(s) in this item: 1

article.pdf (221.8Kb)

Pyridine-3-carbaldehyde 2-pyridylhydrazone

Schaper, KJ; Hansen, Lars Kr; Perlovich, German; Bauer-Brandl, Annette (Journal article; Tidsskriftartikkel; Peer reviewed, 2007)

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URI: http://hdl.handle.net/10037/3177

File(s) in this item: 1

article.pdf (2.559Mb)
Redetermination and H-atom refinement of (S)-(+)-ibuprofen. Corrigendum

Hansen, Lars Kr; Perlovich, German; Bauer-Brandl, Annette (Journal article; Tidsskriftartikkel; Peer reviewed, 2006)

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Abstract: [Erratum to document cited in CA140:010932]

URI: http://hdl.handle.net/10037/3174

File(s) in this item: 1

article.pdf (133.1Kb)
Redetermination of 3-hydroxybenzamide

Hansen, Lars Kr; Perlovich, German; Bauer-Brandl, Annette (Journal article; Tidsskriftartikkel; Peer reviewed, 2007)

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URI: http://hdl.handle.net/10037/3172

File(s) in this item: 1

article.pdf (178.5Kb)

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Abstract:	Dedicated to the memory of Björn Roos (1937–2010), one of the fathers of modern multiconfigurational quantum chemistry, who also cared deeply about chemical applications, and a fun and inspiring friend to countless theoretically oriented chemists.
URI:	http://hdl.handle.net/10037/4086

Abstract:	With its ability to show the interactions between drug-target proteins and small-molecule ligands, X-ray crystallography is an essential tool in drug-discovery programmes. However, its usefulness can be limited by crystallization artifacts or by the data resolution, and in particular when assumptions of unimodal binding (and isotropic motion) do not apply. Discrepancies between the modelled crystal structure and the physiological range of structures generally prevent quantitative estimation of binding energies. Improved crystal structure resolution will often not aid energy estimation because the conditions which provide the highest rigidity and resolution are not likely to reflect physiological conditions. Instead, strategies must be employed to measure and model flexibility and multiple binding modes to supplement crystallographic information. One useful tool is the use of anomalous dispersion for small molecules that contain suitable atoms. Here, an analysis of the binding of the kinase inhibitor H-89 to protein kinase A (PKA) is presented. H-89 contains a bromobenzene moiety that apparently binds with multiple conformations in the kinase ATP pocket. Using anomalous dispersion methods, it was possible to resolve these conformations into two distinct binding geometries.
Description:	This article is part of Alexander Pflugs' doctoral thesis. Available in Munin at http://hdl.handle.net/10037/4145
URI:	http://hdl.handle.net/10037/4645

Description:	Innlegg på seminaret "Science - who cares?" ved NT-fak, Universitetet i Tromsø.
URI:	http://hdl.handle.net/10037/2697

Abstract:	Spot 42 was discovered in Escherichia coli nearly 40 years ago as an abundant, small and unstable RNA. Its biological role has remained obscure until recently, and is today implicated in having broader roles in the central and secondary metabolism. Spot 42 is encoded by the spf gene. The gene is ubiquitous in the Vibrionaceae family of gamma-proteobacteria. One member of this family, Aliivibrio salmonicida, causes cold-water vibriosis in farmed Atlantic salmon. Its genome encodes Spot 42 with 84% identity to E. coli Spot 42. We generated a A. salmonicida spf deletion mutant. We then used microarray and Northern blot analyses to monitor global effects on the transcriptome in order to provide insights into the biological roles of Spot 42 in this bacterium. In the presence of glucose, we found a surprisingly large number of ≥ 2X differentially expressed genes, and several major cellular processes were affected. A gene encoding a pirin-like protein showed an on/off expression pattern in the presence/absence of Spot 42, which suggests that Spot 42 plays a key regulatory role in the central metabolism by regulating the switch between fermentation and respiration. Interestingly, we discovered an sRNA named VSsrna24, which is encoded immediately downstream of spf. This new sRNA has an expression pattern opposite to that of Spot 42, and its expression is repressed by glucose. We hypothesize that Spot 42 plays a key role in the central metabolism, in part by regulating the pyruvat dehydrogenase enzyme complex via pirin.
Description:	The submitted manuscript version of this article is part of Geir Åsmund Hansen's doctoral thesis, which is available in Munin at http://hdl.handle.net/10037/3675
URI:	http://hdl.handle.net/10037/4332

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