Cardiovascular risk factors and risk of venous thromboembolism

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Cardiovascular risk factors and risk of venous thromboembolism

 

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Title: Cardiovascular risk factors and risk of venous thromboembolism
Author: Brækkan, Sigrid Kufaas
Date: 28-Jan-2010
Type: Doctoral thesis; Doktorgradsavhandling
Abstract: Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is a common disease, with serious short- and long-term complications and a potential fatal outcome. Despite the knowledge of several inherited and acquired risk factors for VTE, still 30-50 % of the VTE events occur in the absence of obvious predisposing factors. Traditionally, arterial and venous thrombosis has been considered as separate disease entities with different pathology, epidemiology and treatments. However, recently this concept has been challenged, and a potential link between arterial cardiovascular disease and VTE has been suggested. The aim of this thesis was to investigate the impact of traditional cardiovascular risk factors on the risk of VTE in a prospective population-based study. Subjects were recruited from the fourth survey of the Tromsø study, conducted in 1994-95. A total of 27 158 men and women, aged 25-97 years, participated. Incident VTE events were registered from the date of inclusion through the end of follow-up, September 1, 2007. In summary, age, male gender, obesity, mean platelet volume and family history of myocardial infarction were identified as risk factors for venous thrombosis, which makes these factors, shared risk factors for both arterial and venous thrombosis. Other traditional cardiovascular risk factors such as serum lipid levels, blood pressure, smoking and diabetes were not associated with risk of VTE. Subjects with the metabolic syndrome had higher risk of VTE, but this relationship was essentially dependent on the presence of abdominal obesity. Taken together, these findings imply that traditional atherosclerotic risk factors are not shared by arterial and venous thrombosis, and suggest that common determinants for arterial and venous thrombosis are probably related to mechanisms of thrombus formation.
Description: The papers of the thesis are not available in Munin, due to publisher's restrictions:
1. Brækkan SK, Mathiesen EB, Njølstad I, Wilsgaard T, Størmer J, Hansen JB: 'Family history of myocardial infarction is an independent risk factor for venous thromboembolism – The Tromsø Study', Journal of Thrombosis and Haemostasis, 2008, Nov; 6(11): 1851–1857 (Wiley-Blackwell). Available at http://dx.doi.org/10.1111/j.1538-7836.2008.03102.x
2. Borch KH, Brækkan SK, Mathiesen EB, Njølstad I, Wilsgaard T, Størmer J, Hansen JB: 'Abdominal obesity is essential for the risk of venous thromboembolism in the metabolic syndrome - the Tromsø study', Journal of Thrombosis and Haemostasis, 2009 May; 7(5): 739-45. Available at http://dx.doi.org/10.1111/j.1538-7836.2008.03234.x
3. Brækkan SK, Borch KH, Mathiesen EB, Njølstad I, Wilsgaard T, Hansen JB: 'HDL-cholesterol and future risk of venous thromboembolism – The Tromsø Study', Journal of Thrombosis and Haemostasis, 2009 Aug; 7(8): 1428-30. Available at http://dx.doi.org/10.1111/j.1538-7836.2009.03481.x
4. Brækkan SK, Mathiesen EB, Njølstad I, Wilsgaard T, Størmer J, Hansen JB: 'Mean platelet volume is an independent risk factor for venous thromboembolism – The Tromsø Study', Journal of Thrombosis and Haemostasis, 2010 Jan; 8(1): 157-162. Available at http://dx.doi.org/10.1111/j.1538-7836.2009.03498.x
Publisher: Universitetet i Tromsø; University of Tromsø
URI: http://hdl.handle.net/10037/2433


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