Nye registreringer

  • FITC conjugation markedly enhances hepatic clearance of N-formyl peptides 

    Øie, Cristina Ionica; Snapkov, Igor; Elvevold, Kjetil; Sveinbjørnsson, Baldur; Smedsrød, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-05)
    In both septic and aseptic inflammation, N-formyl peptides may enter the circulation and induce a systemic inflammatory response syndrome similar to that observed during septic shock. The inflammatory response is brought ...
  • Estrogen receptors α and β and aromatase as independent predictors for prostate cancer outcome 

    Grindstad, Thea; Skjefstad, Kaja; Andersen, Sigve; Ness, Nora; Nordby, Yngve; Al-Saad, Samer; Fismen, Silje; Dønnem, Tom; Rakaee, Mehrdad; Busund, Lill-Tove; Bremnes, Roy M.; Richardsen, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-09)
    Androgens are considered important in normal prostate physiology and prostate cancer (PCa) pathogenesis. However, androgen-targeted treatment preventing PCa recurrence is still lacking. This indicates additional mediators ...
  • Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer 

    Puvirajesinghe, Tania M.; Bertucci, François; Jain, Ashish; Scerbo, Pierluigi; Belotti, Edwige; Audebert, Stéphane; Sebbagh, Michael; Lopez, Marc; Brech, Andreas; Finetti, Pascal; Charafe-Jauffret, Emmanuelle; Chaffanet, Max; Restouin, Audrey; Marchetto, Sylvie; Collette, Yves; Gonçalvès, Anthony; Macara, Ian; Birnbaum, Daniel; Kodjabachian, Laurent; Johansen, Terje; Borg, Jean-Paul (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-12)
    The non-canonical Wnt/planar cell polarity (Wnt/PCP) pathway plays a crucial role in embryonic development. Recent work has linked defects of this pathway to breast cancer aggressiveness and proposed Wnt/PCP signalling ...
  • Fibroblast miR-210 overexpression is independently associated with clinical failure in Prostate Cancer – a multicenter (in situ hybridization) study 

    Andersen, Sigve; Richardsen, Elin; Moi, Line; Dønnem, Tom; Nordby, Yngve; Ness, Nora; Eilertsen Holman, Marte; Bremnes, Roy M.; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-08)
    There is a need for better prognostication in prostate cancer (PC). “The micromanager of hypoxia”, microRNA-210 (miR-210) is directly linked to hypoxia, is overexpressed in PC and has been implied in tumor cell-fibroblast ...
  • Altered pharmacological effects of adrenergic agonists during hypothermia 

    Dietrichs, Erik Sveberg; Sager, Georg; Tveita, Torkjel (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-05)
    Rewarming from accidental hypothermia is often complicated by hypothermia-induced cardiac dysfunction, calling for immediate pharmacologic intervention. Studies show that although cardiac pharmacologic support is applied when ...
  • Anti-human platelet antigen-1α immunoglobulin G preparation intended to prevent fetal and neonatal alloimmune thrombocytopenia 

    Weng, Ying-Jan; Husebekk, Anne; Skogen, Bjørn Ragnar; Killie, Mette Kjær; Lin, Liang-Tzung; Burnouf, Thierry (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-14)
    Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a severe disease that is caused by maternal alloantibodies generated during pregnancy or at delivery as a result of incompatibility between maternal and fetal ...
  • Presence of TMPRSS2-ERG is associated with alterations of the metabolic profile in human prostate cancer 

    Hansen, Ailin Falkmo; Sandsmark, Elise; Rye, Morten Beck; Wright, Alan J; Bertilsson, Helena; Richardsen, Elin; Viset, Trond; Bofin, Anna M.; Angelsen, Anders; Selnæs, Kirsten Margrete; Bathen, Tone Frost; Tessem, May-Britt (Tidsskriftartikkel; Peer reviewed; Journal article, 2016-06-03)
    TMPRSS2-ERG has been proposed to be a prognostic marker for prostate cancer. The aim of this study was to identify changes in metabolism, genes and biochemical recurrence related to TMPRSS2-ERG by using an integrated ...
  • A novel non-canonical Wnt signature for prostate cancer aggressiveness 

    Sandsmark, Elise; Hansen, Ailin Falkmo; Selnæs, Kirsten Margrete; Bertilsson, Helena; Bofin, Anna M.; Wright, Alan J.; Viset, Trond; Richardsen, Elin; Drabløs, Finn Sverre; Bathen, Tone Frost; Tessem, May-Britt; Rye, Morten Beck (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-24)
    Activation of the Canonical Wnt pathway (CWP) has been linked to advanced and metastatic prostate cancer, whereas the Wnt5a-induced non-canonical Wnt pathway (NCWP) has been associated with both good and poor prognosis. A ...
  • Direct small RNA signatures in extracellular vesicles from breast cancer cell lines 

    Fiskaa, Tonje; Knutsen, Erik; Nikolaisen, Malene; Jørgensen, Tor Erik; Johansen, Steinar Daae; Perander, Maria; Seternes, Ole Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-31)
    Breast cancer is a heterogeneous disease, and different subtypes of breast cancer show distinct cellular morphology, gene expression, metabolism, motility, proliferation, and metastatic potential. Understanding the ...
  • Primary cervical cancer screening with an HPV mRNA test: a prospective cohort study 

    Sørbye, Sveinung Wergeland; Fismen, Silje; Gutteberg, Tore Jarl; Mortensen, Elin Synnøve; Skjeldestad, Finn Egil (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-11)
    <b>Objectives</b> To assess the performance of a 5-type human papillomavirus (HPV) messenger RNA (mRNA) test in primary screening within the framework of the Norwegian population-based screening programme. <br> <b>Design</b> ...
  • A Look into the Melting Pot: The mecC-Harboring Region Is a Recombination Hot Spot in Staphylococcus stepanovicii 

    Semmler, Torsten; Harrison, Ewan M.; Lübke-Becker, Antina; Ulrich, Rainer G.; Wieler, Lothar H.; Guenther, Sebastian; Stamm, Ivonne; Hanssen, Anne-Merethe; Holmes, Mark A.; Vincze, Szilvia; Walther, Birgit (Journal article, 2016-01-22)
    INTRODUCTION Horizontal gene transfer (HGT) is an important driver for resistance- and virulence factor accumulation in pathogenic bacteria such as Staphylococcus aureus. METHODS Here, we have investigated the ...
  • Multiple specialised goose-type lysozymes potentially compensate for an exceptional lack of chickentype lysozymes in Atlantic cod 

    Seppola, Marit; Bakkemo, Kathrine Ryvold; Mikkelsen, Helene V.; Myrnes, Bjørnar; Helland, Ronny; Irwin, David; Nilsen, Inge Waller (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-21)
    Previous analyses of the Atlantic cod genome showed unique combinations of lacking and expanded number of genes for the immune system. The present study examined lysozyme activity, lysozyme gene distribution and expression ...
  • Differentially Expressed MicroRNAs in Meningiomas Grades I and II Suggest Shared Biomarkers with Malignant Tumors 

    El-Gewely, Mohamed Raafat; Andreassen, Morten; Walquist, Mari; Ursvik, Anita; Knutsen, Erik; Nystad, Mona; Coucheron, Dag H; Myrmel, Kristin Smistad; Hennig, Rune; Johansen, Steinar D (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-03)
    Meningiomas represent the most common primary tumors of the central nervous system, but few microRNA (miRNA) profiling studies have been reported so far. Deep sequencing of small RNA libraries generated from two human ...
  • The interaction between Staphylococcus aureus SdrD and desmoglein 1 is important for adhesion to host cells 

    Askarian, Fatemeh; Ajayi, Clement; Hanssen, Anne-Merethe; Van Sorge, Nina M.; Pettersen, Ingvild; Diep, Dzung Bao; Sollid, Johanna U. Ericson; Johannessen, Mona (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-29)
  • Production and purification of recombinant C-terminal truncated pro-Matrix Metalloprotease-9 

    Rahman, Fatema (Master thesis; Mastergradsoppgave, 2016-06-21)
    MMP-9 consists of N-terminal signal peptide, a pro-domain, catalytic domain, a long flexible hinge region and C- terminal hemopexin domain. In the present study a truncated version of proMMP-9 which lacking hinge region ...
  • An investigation of Intercellular Adhesion Molecule-1 (ICAM-1) in Breast Cncer 

    Elston, Bryan George Vincent (Master thesis; Mastergradsoppgave, 2016-05-18)
    Intercellular Adhesion Molecule-1 (ICAM-1, CD54), a cell surface glycoprotein that functions as an integrin, has a well-established role in leukocyte migration during inflammation. Recent studies have indicated a role for ...
  • Synthesis, biological evaluation and molecular modeling studies of the PPARβ/δ antagonist CC618 

    Kaupang, Åsmund; Paulsen, Steinar Martin; Steindal, Calin Constantin; Ravna, Aina Westrheim; Sylte, Ingebrigt; Halvorsen, Trine Grønhaug; Thoresen, G. Hege; Hansen, Trond Vidar (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-05)
    Abstract: Herein, we describe the synthesis, biological evaluation and molecular docking of the selective PPARb/ d antagonist (4-methyl-2-(4-(trifluoromethyl)phenyl)-N-(2-(5-(trifluoromethyl)-pyridin-2-ylsulfonyl) et ...
  • Synthesis, biological evaluation and molecular modeling of new analogs of the anti-cancer agent 2-methoxyestradiol: potent inhibitors of angiogenesis 

    Solum, Eirik Johansson; Cheng, Jing-Jy; Sylte, Ingebrigt; Vik, Anders; Hansen, Trond Vidar (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-27)
    The synthesis, cytotoxicity, inhibition of tubulin polymerization and anti-angiogenic effects of 10 analogs of 2-methoxyestradiol are reported. These efforts revealed that the analog with a 4-pyridine ring in the 17-position, ...
  • CD45RO+ Memory T Lymphocytes – a Candidate Marker for TNM-Immunoscore in Squamous Non-Small Cell Lung Cancer 

    Paulsen, Erna-Elise; Kilvær, Thomas Karsten; Rakaeekhanehkenari, Mehrdad; Johansen Maurseth, Ramona; Al-Saad, Samer; Hald, Sigurd; Al-Shibli, Khalid; Andersen, Sigve; Richardsen, Elin; Busund, Lill-Tove; Bremnes, Roy M.; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11)
    Tumor-infiltrating lymphocytes (TILs) are vital in limiting cancer progression and may supplement the TNM classification. CD45RO+ memory TILs show major prognostic impact in various malignancies but have not been extensively ...
  • Borrelia burgdorferi sensu lato-infected Ixodes ricinus collected from vegetation near the Arctic Circle 

    Hvidsten, Dag; Stordal, Frode; Lager, Malin; Rognerud, Bjørg; Kristiansen, Bjørn Erik; Matussek, Andreas; Gray, Jeremy; Stuen, Snorre (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-07-06)
    This is the first study to determine the density of questing Ixodes ricinus in northern Norway. It was performed at two sites in Brønnøy, which has been known for its tick permissive habitats for decades and is one of ...

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