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dc.contributor.authorBasnet, Purusotam
dc.contributor.authorSkalko-Basnet, Natasa
dc.date.accessioned2012-03-01T12:16:45Z
dc.date.available2012-03-01T12:16:45Z
dc.date.issued2011
dc.description.abstractOxidative damage and inflammation have been pointed out in preclinical studies as the root cause of cancer and other chronic diseases such as diabetes, hypertension, Alzheimer’s disease, etc. Epidemiological and clinical studies have suggested that cancer could be prevented or significantly reduced by treatment with anti-oxidant and anti-inflammatory drugs, therefore, curcumin, a principal component of turmeric (a curry spice) showing strong anti-oxidant and anti-inflammatory activities, might be a potential candidate for the prevention and/or treatment of cancer and other chronic diseases. However, curcumin, a highly pleiotropic molecule with an excellent safety profile targeting multiple diseases with strong evidence on the molecular level, could not achieve its optimum therapeutic outcome in past clinical trials, largely due to its low solubility and poor bioavailability. Curcumin can be developed as a therapeutic drug through improvement in formulation properties or delivery systems, enabling its enhanced absorption and cellular uptake. This review mainly focuses on the anti-inflammatory potential of curcumin and recent developments in dosage form and nanoparticulate delivery systems with the possibilities of therapeutic application of curcumin for the prevention and/or treatment of cancer.en
dc.identifier.citationMolecules 16(2011) s. 4567-4598en
dc.identifier.issn1420-3049
dc.identifier.nb-fulltextFulltext http://www.ub.uit.no/munin/bitstream/10037/3877/1/article.pdf
dc.identifier.nb-urnURN URN:NBN:no-uit_munin_3599
dc.identifier.otherFRIDAID 806916
dc.identifier.otherdoi: 10.3390/molecules16064567
dc.identifier.urihttp://hdl.handle.net/10037/3877
dc.identifier.urnURN:NBN:no-uit_munin_3599
dc.language.isoengen
dc.publisherMoleculesen
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Pharmacology: 728en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Farmakologi: 728en
dc.titleCurcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatmenten
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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