Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment

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Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment

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dc.contributor.author Basnet, Purusotam
dc.contributor.author Skalko-Basnet, Natasa
dc.date.accessioned 2012-03-01T12:16:45Z
dc.date.available 2012-03-01T12:16:45Z
dc.date.issued 2011
dc.description.abstract Oxidative damage and inflammation have been pointed out in preclinical studies as the root cause of cancer and other chronic diseases such as diabetes, hypertension, Alzheimer’s disease, etc. Epidemiological and clinical studies have suggested that cancer could be prevented or significantly reduced by treatment with anti-oxidant and anti-inflammatory drugs, therefore, curcumin, a principal component of turmeric (a curry spice) showing strong anti-oxidant and anti-inflammatory activities, might be a potential candidate for the prevention and/or treatment of cancer and other chronic diseases. However, curcumin, a highly pleiotropic molecule with an excellent safety profile targeting multiple diseases with strong evidence on the molecular level, could not achieve its optimum therapeutic outcome in past clinical trials, largely due to its low solubility and poor bioavailability. Curcumin can be developed as a therapeutic drug through improvement in formulation properties or delivery systems, enabling its enhanced absorption and cellular uptake. This review mainly focuses on the anti-inflammatory potential of curcumin and recent developments in dosage form and nanoparticulate delivery systems with the possibilities of therapeutic application of curcumin for the prevention and/or treatment of cancer.
dc.identifier.citation Molecules 16(2011) s. 4567-4598
dc.identifier.issn 1420-3049
dc.identifier.other FRIDAID 806916
dc.identifier.other doi: 10.3390/molecules16064567
dc.identifier.uri http://hdl.handle.net/10037/3877
dc.identifier.urn URN:NBN:no-uit_munin_3599
dc.language.iso eng
dc.publisher Molecules
dc.subject VDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Pharmacology: 728
dc.subject VDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Farmakologi: 728
dc.title Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment
dc.type Journal article
dc.type Tidsskriftartikkel
dc.type Peer reviewed


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