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Smedsrød, Bård (Book; Bok, 31-Aug-2008)[+][-]
Abstract: Abstract book of the symposium URI: http://hdl.handle.net/10037/1654 File(s) in this item: 1
book.pdf (1.588Mb) -
Henninen, Anita Pettersen (Master thesis; Mastergradsoppgave, 12-May-2010)[+][-]
Abstract: Studien er en kvalitativ undersøkelse og et kvalitativt forskningsintervju er benyttet som metode i tilvirkningen av data. Undersøkelsen har fokus mot foreldres erfaringer ved å skulle gjennomføre 24 timers posisjonering, inkludert tilpasset sovesystem på natten, for eget barn. Det er relativt lite erfaring her i Norge med å tenke posisjonering hele døgnet for barn med store bevegelsesvansker, og få studier retter seg mot foreldreopplevelsen ved implementering av denne tilnærmingen. Hensikten har vært å få innsikt i hva foreldre ser som muligheter og utfordringer med gjennomføring av 24 timers posisjonering for barnet sitt samt hva som synes vesentlig for at dette skal lykkes. Utvalget har bestått av to informanter som er foreldre til barn med spastisk quadriplegi. Barna har benyttet et tilpasset sovesystem på natten i tillegg til de hjelpemidlene de benytter på dagtid. I første del av oppgaven presenteres teori som har vært sentral i analysen av studiens resultater. Det redegjøres også for 24 timers posisjonering samt forskning på dette feltet. I studiens hoveddel presenteres undersøkelsens resultater med påfølgende diskusjon av disse. Undersøkelsen viser at det er nødvendig med en tilvenningsfase når barna skal starte med 24 timers posisjonering, og det kreves en individuell tilpasning til sovesystemet. Videre viser den at barnas sovestilling ble mer symmetrisk etter at de begynte med posisjonering om natten. Hjelpemidlene barnet benytter på dagtid synes å ha en vesentlig funksjon i forhold til barnets aktivitet dersom de er riktig tilpasset barnet. Videre kommer det frem at det vesentlige for at 24 timers posisjonering skal kunne gjennomføres er informasjon om tilnærmingen, at nærpersoner er villige til å ta den eventuelle belastningen dette medfører en periode, og at det eksisterer kunnskap om, og en felles forståelse for 24 timers posisjonering hos de som hjelper barnet. URI: http://hdl.handle.net/10037/2559 File(s) in this item: 1
thesis.pdf (2.517Mb) -
Kiselev, Yury; Eriksen, Tonje Engevik; Forsdahl, Siri; Nguyen, Lan Huong Thi; Mikkola, Ingvild (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)[+][-]
Abstract: Pax6 and Pax6(5a) are two isoforms of the evolutionary conserved Pax6 gene often co-expressed in specific stochiometric relationship in the brain and the eye during development. The Pax6(5a) protein differs from Pax6 by having a 14 amino acid insert in the paired domain, causing the two proteins to have different DNA binding specificities. Difference in functions during development is proven by the fact that mutations in the 14 amino acid insertion for Pax6(5a) give a slightly different eye phenotype than the one described for Pax6. Whereas quite many Pax6 target genes have been published during the last years, few Pax6(5a) specific target genes have been reported on. However, target genes identified by Pax6 knockout studies can probably be Pax6(5a) targets as well, since this isoform also will be affected by the knockout. In order to identify new Pax6 target genes, and to try to distinguish between genes regulated by Pax6 and Pax6(5a), we generated FlpIn-3T3 cell lines stably expressing Pax6 or Pax6(5a). RNA was harvested from these cell lines and used in gene expression microarrays where we identified a number of genes differentially regulated by Pax6 and Pax6(5a). A majority of these were associated with the extracellular region. By qPCR we verified that Ncam1, Ngef, Sphk1, Dkk3 and Crtap are Pax6(5a) specific target genes, while Tgfbi, Vegfa, EphB2, Klk8 and Edn1 were confirmed as Pax6 specific target genes. Nbl1, Ngfb and seven genes encoding different glycosyl transferases appeared to be regulated by both. Direct binding to the promoters of Crtap, Ctgf, Edn1, Dkk3, Pdgfb and Ngef was verified by ChIP. Furthermore, a change in morphology of the stably transfected Pax6 and Pax6(5a) cells was observed, and the Pax6 expressing cells were shown to have increased proliferation and migration capacities. URI: http://hdl.handle.net/10037/4107 File(s) in this item: 1
article.pdf (927.5Kb) -
Fjellhøy, Åse-Gunn; Steene, Hege Liljedahl (Master thesis; Mastergradsoppgave, 2004)[+][-]
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Slåtsve, Arne Martin (Mastergradsoppgave; Master thesis, 15-Sep-2009)[+][-]
Abstract: ABC (ATP-binding cassette)-transportører er store, evolusjonsmessig høykonserverte membranproteiner som er påvist i alle arter fra prokaryoter til komplekse organismer. ABC-transportørene muliggjør energiavhengig transport av spesifikke substrater gjennom cellemembraner. Blant substratene vi kjenner er lipider, karbohydrater, peptider, vitaminer, steroidhormoner, xenobiotika og medikamenter. ABC-transportørene kjennetegnes av to karakteristiske ATP-bindende kassetter og to komplekse transmembrane domener. I de ATP-bindende kassettene genereres energi til substrattransporten ved ATP-hydrolyse. De transmembrane domenene forankrer ABC-transportørene i cellemembranen og danner transportveien gjennom denne. Det humane genom har 48 identifiserte ABC-transportørgener. Genene inndeles på bakgrunn av strukturlikhet i sju klasser (ABCA – ABCG). I løpet av de siste 30 årene har forskningen avdekket stadig mer om ABC-transportørenes fysiologiske betydning, deres rolle i patologien og farmakologien. I dag vet man at disse proteinene forhindrer fritt opptak av en rekke medikamenter fra GI-tractus, samt begrenser distribusjonen av medikamenter til blant annet hjernen, placenta, testes og hjertet. Transportørene er også sentrale i såkalt multimedikamentell resistens hos cancerceller og mikroorganismer. Man har utviklet flere måter å manipulere transportørene på - blant annet ved bruk av såkalte inhibitorer, for å bedre opptak og distribusjon av medikamenter. Mutasjoner i ABC-genene forårsaker en rekke sykdommer, og genene er gjenstand for til dels betydelige individuelle og etniske variasjoner. I denne litteraturstudien vil den mest sentrale kunnskapen om ABC-transportørene bli presentert. Innledningsvis vil historien om deres oppdagelse bli skissert, etterfulgt av generelle fakta om deres funksjon, struktur, regulering og evolusjonære opphav. Enkelte genetiske sykdommer vil også bli omtalt. Avslutningsvis vil ABC-transportørenes rolle i farmakokinetikken bli belyst. URI: http://hdl.handle.net/10037/2261 File(s) in this item: 1
thesis.pdf (281.8Kb) -
Skjeldal, Hege (Master thesis; Mastergradsoppgave, 2006)[+][-]
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Rudmin, Floyd Webster (Journal article; Tidsskriftartikkel, 2007)[+][-]
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Eliassen, Bent-Martin; Braaten, Tonje; Melhus, Marita; Hansen, Ketil Lenert; Broderstad, Ann Ragnhild (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)[+][-]
Abstract: Acculturation is for indigenous peoples related to the process of colonisation over centuries as well as the on-going social transition experienced in the Arctic today. Changing living conditions and lifestyle affect health in numerous ways in Arctic indigenous populations. Self-rated health (SRH) is a relevant variable in primary health care and in general public health assessments and monitoring. Exploring the relationship between acculturation and SRH in indigenous populations having experienced great societal and cultural change is thus of great importance. The principal method in the Survey of Living Conditions in the Arctic (SLiCA) was standardised face-to-face interviews using a questionnaire. Very high overall participation rates of 83% were obtained in Greenland and Alaska, whilst a more conventional rate of 57% was achieved in Norway. Acculturation was conceptualised as certain traditional subsistence activities being of lesser importance for people’s ethnic identity, and poorer spoken indigenous language ability (SILA). Acculturation was included in six separate gender- and country-specific ordinal logistic regressions to assess qualitative effects on SRH. Multivariable analyses showed that acculturation significantly predicted poorer SRH in Greenland. An increased subsistence score gave an OR of 2.32 (P<0.001) for reporting poorer SRH among Greenlandic men, while an increased score for Greenlandic women generated an OR of 1.71 (P=0.01). Poorer SILA generated an OR of 1.59 in men (p=0.03). In Alaska, no evidence of acculturation effects was detected among Iñupiaq men. Among Iñupiaq women, an increased subsistence score represented an increased odds of 73% (p=0.026) for reporting poorer SRH. No significant effects of acculturation on SRH were detected in Norway. This study shows that aggregate acculturation is a strong risk factor for poorer SRH among the Kalaallit of Greenland and female Iñupiat of Alaska, but our cross-sectional study design does not allow any conclusion with regard to causality. Limitations with regard to wording, categorisations, assumed cultural differences in the conceptualisation of SRH, and confounding effects of health care use, SES and discrimination, make it difficult to appropriately assess how strong this effect is though. URI: http://hdl.handle.net/10037/4625 File(s) in this item: 1
article.pdf (250.3Kb) -
Rudmin, Floyd Webster (Preprint; Manuskript, Oct-2003)[+][-]
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Seredkina, Natalya; Rekvik, Ole Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)[+][-]
Abstract: An acquired loss of renal DNaseI has recently been shown to promote transformation of mild mesangial lupus nephritis into membrano-proliferative end-stage organ disease. In this study, we analyzed expression profiles of DNaseI in other organs of lupus-prone (NZBxNZW)F1 mice during disease progression to determine if silencing of the renal DNaseI gene is an organ specific feature or if loss of DNaseI reflects a systemic error in mice with sever lupus nephritis. Our results demonstrate normal or elevated levels of DNaseI mRNA and enzyme activity in liver, spleen and serum samples of (NZBxNZW)F1 mice throughout all stages of lupus nephritis. DNaseI activity was dramatically reduced only in kidneys of mice with sever nephritis and was the only nuclease that was down-regulated, while 6 other nucleases (DNaseIl1-3, caspase activated deoxyribonuclease, Dnase2a, and endonuclease G) were largely normally expressed in kidneys, liver and spleen. Loss of renal DNaseI was not accompanied by changes in serum DNaseI activity, suggesting an independent mechanism of DNaseI regulation in circulation and in kidneys, and an absence of compensatory upregulation of serum DNaseI activity in case of renal DNaseI deficiency. Thus, silencing of renal DNaseI is a unique renal feature in membrano-proliferative lupus nephritis. Determination of mechanism(s) responsible for DNaseI down-regulation is a future step in generation of new therapeutic targets to treat and prevent progressive lupus nephritis. Description: Accepted manuscript version, reprinted with permission (Elsevier).
Published version available at http://dx.doi.org/10.1016/j.ajpath.2011.05.011
This article is part of Natalya Serdkina's doctoral thesis which is available in Munin at http://hdl.handle.net/10037/3563URI: http://hdl.handle.net/10037/3564 File(s) in this item: 1
article.pdf (790.3Kb) -
Willumsen, Sigrid Serine (Master thesis; Mastergradsoppgave, 20-May-2008)[+][-]
Abstract: Very little is known about introgression in bacteria. Introgression is the process where the genes of one species infiltrate the gene pool of another organism by subsequent backcross transformations of a hybrid with one of its parents. After the initial acquisition of foreign DNA, DNA from the newly made transformants is used as donor DNA in backcross transformations with the recipient. DNA is released to the environment after decomposing of dead cells, disrupting of cells or through excretion from living organisms. The extracellular DNA can be degraded after release, thus fragmented DNA can be taken up by bacteria. One previous unpublished study investigated the effect of introgression of foreign unselected DNA. The donor DNA in this study was of high molecular weight (20 to 30 kilo bases (Kb)) and it was suggested that introgression in backcross transformation could be a mechanism by which unselected DNA was eliminated from the genome. I wanted to study the effect of introgression when the foreign donor DNA was of low molecular weight (1000 to 4000 base pairs (bp)). We wanted to determine how fragmentation affects the speed at which unselected DNA from Acinetobacter sp. strain 16.4 was eliminated from the genome of Acinetobacter baylyi strain BD413 during the introgression process. I have developed a method for optimal fragmentation of DNA to the desired size for this study. The DNA was fragmented by sonication, which gave an effective, gradual reduction in the fragment size of DNA. The size of the sonicated DNA was checked on an agarose gel and I found out that a gel fraction between 1000 to 4000 bp was the desired size for fragmented DNA. The DNA was extracted from the gel piece and used as low molecular weight donor DNA. This method can be used to determine the effect of introgression when the foreign donor DNA is of low molecular weight (1000 to 4000 base pairs bp) and to get a better understanding for natural fragmentation of extracellular DNA in the environment. URI: http://hdl.handle.net/10037/1590 File(s) in this item: 1
thesis.pdf (2.637Mb) -
Ruba, Wael Abdulhafeeth (Master thesis; Mastergradsoppgave, 15-Dec-2010)[+][-]
Abstract: Using mobiles for health related purposes have been studied for a while and new concepts such as mhealth have been introduced. The latter is believed to have a great potential in taking health related applications to a higher level especially with the introduction of a high-tech mobile phones called “smartphones”. This research presents different aspects of mobile’s potentials that have been employed in ActiveTeen which is a Mobile Social Networking Mapping and Gaming Application that intends to help adolescents in doing at least 1 hour of physical activity. URI: http://hdl.handle.net/10037/2956 File(s) in this item: 2
Source Code and UML Design.zip (21.81Mb)thesis.pdf (3.286Mb) -
Møkleby, Tormund Aasjord (Master thesis; Mastergradsoppgave, May-2009)[+][-]
Abstract: Gemcitabine is a well established anticancer compound, and is in use today against several types of cancers. Gemcitabine has a short half life. Formulations of gemcitabine containing liposomes could extend it's half life, thereby maybe improving its effectiveness. Also, liposomes in the smaller size range have an advantage when it comes to treating cancer. They accumulate at the site of the tumor, and stay there for a longer time than it would have done in normal tissue(Massing and Fuxius 2000). Previous attempts to actively load gemcitabine into liposomes have used a pH gradient with acidic pH inside compared to more neutral pH on the outside of the liposomes, accomplished by an ammonium sulphate gradient. But this approach showed some difficulties; among other things that gemcitabine had a tendency to leak out in very short time. (Gravem 2006). In this thesis I have among other things investigated the possibility of loading gemcitabine into liposomes by precipitation. The hope was that this could give higher trapping efficiency and reduced leakage compared to the ammonium sulphate approach. Firstly, for comparable reasons and method development, an approach to load liposomes via an ammonium sulphate gradient was tried. Thought after encountering several problems the experiment was ended without any results indicating loading, most likely due to heavily diluted liposomes. Secondly I investigated if I could make gemcitabine precipitate. Firstly I tried a great range of different phosphate and sulphate salts, to test if any of them would cause a precipitation. Precipitation seemed to be independent of which salt used, but enhanced by factors such as high concentration of gemcitabine, alkaline conditions (pH ≥ 6), and low temperature. The two last conditions were the total opposites of loading via an ammonium sulphate gradient, and contained several contradictions as it meant that the outer pH had to be significantly lower to avoid precipitation and that a low temperature made it harder for gemcitabine to cross the membrane of the liposomes. An attempt to load gemcitabine into liposomes, using a pH 4 in the outer phase and pH 7 in the inner phase of the liposomes, with repeated cooling and freezing cycles, revealed poor loading. Thought optimizing conditions such as pHs, and time and temperatures in the cooling freezing cycles might enhance the loading a bit it is difficult to see this approach becoming a success. URI: http://hdl.handle.net/10037/2202 File(s) in this item: 1
thesis.pdf (1.114Mb) -
Damsgård, Elin (Doctoral thesis; Doktorgradsavhandling, 26-Feb-2010)[+][-]
Abstract: Chronic musculoskeletal pain is a common health problem and a major cause for disability pension in Norway. Increased pain and fear related to general activity and exercise may be a barrier to rehabilitation of patients with chronic muscular-skeletal disorders.
The aim of the present research was to investigate the occurrence of activity related pain, and to explore its association with fear, psychological distress, self efficacy and pain (duration and distribution). The second aim was to explore how these psychological aspects and activity related pain associates with individuals’ readiness to adopt a self-management approach to pain, and how patients described and explained such pain experiences.
Data were collected by questionnaires and qualitative interviews with out-patients at a Physical Medicine clinic at the University Hospital of Northern Norway. Results showed that a majority of the participants experienced increased pain during activity. Pain related fear of movement/(re)injury was a unidimensional construct, which was statistically significantly associated with increased pain during activity, also among individuals without psychological distress. Participants with high levels of fear of movement/(re)injury and psychological distress and weak sense of (pain) self efficacy were more likely to report pain during activity. They were also less ready to take a self-management approach to pain. Activity related pain was described and explained as a complex experience with diverse meanings. Initial fear of pain was re-interpreted under the influence of time, learning and own experience. Participating in social life situations was an important incentive to stay active despite pain.URI: http://hdl.handle.net/10037/2500 File(s) in this item: 6
paper_1.pdf (602.5Kb)paper_2.pdf (336.4Kb)paper_3.pdf (324.0Kb)paper_4.pdf (402.5Kb)(more files) -
Damsgård, Elin; Thrane, Gyrd; Anke, Audny; Fors, Terese; Røe, Cecilie (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)[+][-]
Abstract: Purpose. Activity related pain may be a barrier to rehabilitation in patients with chronic musculoskeletal disorders. This study investigated patients’ reports of increased pain during activity, and the association between such pain and psychological factors and pain variables. Method. Questionnaires from 232 adults with chronic musculoskeletal pain measured pain intensity, spread of pain and pain duration. Pain during activity was assessed both on a 11 point Numeric Rating Scale (NRS), and operationalized as a dichotomous measure, where responders defined if they experienced pain during general activity and exercise. Psychological factors were measured by the Hopkins Symptom Check List 25, the Tampa Scale for Kinesiophobia and a subscale of the Arthritis Self – Efficacy Scale. Multiple and logistic regression was used to analyse associations between increased pain during activity and associated variables. Results. Increased pain during activity was reported by 69 % of participants. Fear of movement was a significant factor for reporting increased pain during activity, both general activity and exercise, also in a subsample with low psychological distress. Other significant factors were spread of pain and a low sense of self efficacy. Conclusion. Patients with high fear of movement, large spread of pain and low self efficacy were more likely to report increased pain during activity even in the absence of psychological distress. Description: Accepted manuscript version, reprinted with permission (Informa Helthcare).
Published version available at http://dx.doi.org/10.3109/09638280903567877
This article is part of Elin Damsgård's doctoral thesis which is available in Munin at http://hdl.handle.net/10037/2500URI: http://hdl.handle.net/10037/3549 File(s) in this item: 1
article.pdf (336.4Kb) -
Stub, Trine (Master thesis; Mastergradsoppgave, 15-Jun-2009)[+][-]
Abstract: Background:For more than 2000 years acupuncture has been used to treat depression and randomized controlled trials (RCT) have been conducted to investigate their efficacy.Objectives: The objectives of this overview is to assess the effects and adverse effects of acupuncture in patients with depression, and to evaluate the report quality of acupuncture treatment for depression in randomized controlled trials and systematic reviews. Search Strategy: Six different electronical databases were searched, combined with manual searches in journals of interest and reference lists. Selection Criteria:Systematic reviews and randomiced trials of acupuncture for depression compared to medication, waiting list, non-spesific acupuncture and placebo were included.Main Result:Four systematic reviews and eighteen RCTs were analyzed. The methodological quality of trials reports were generally low. A significant reduction in depression was found by electro-acupuncture compared to antidepressant medication.And a significant beneficial effects was found for classical acupuncture in improving and reducing depression compared to placebo. Conclusion: More rigorouse trials are needed and long-term effects should be investigated if acupuncture is to be recommended as one of the alternative treatments for depression. URI: http://hdl.handle.net/10037/3707 File(s) in this item: 1
thesis.pdf (417.6Kb) -
Hermansen, Stig Eggen (Doctoral thesis; Doktorgradsavhandling, 01-Nov-2012)[+][-]
Abstract: Akutt hjertesvikt, spesielt ved sirkulatorisk kollaps, er en dramatisk tilstand med høy dødelighet. Forekomsten av akutt hjertesvikt er økende og tilgjengelig kunnskap om sykdomsmekanismene samt medisinsk behandling er begrenset.De siste tiår har det vært en revolusjonerende utvikling i behandlingen av og overlevelsen ved iskemisk hjertesykdom og akutt hjerteinfarkt. Tilsvarende utvikling har det dessverre ikke vært i behandlingen av akutt hjertesvikt som er et økende problem assosiert med høy dødelighet. Formålet med dette prosjektet har vært å kartlegge epidemiologi, behandling og prognose ved forskjellige typer akutt hjertesvikt. For å øke den patofysiologiske forståelsen av sirkulasjonsregulering ved de mest alvorlige former for akutt hjertesvikt (kardiogent sjokk) har vi gjennomført observajonsstudier av biokjemiske responser og perifer karfunksjon i sykdomsforløpet. Prosjektet har vært todelt. Vi har først har sett på forekomsten av forskjellige typer akutt hjertesvikt og behandlingen som ble gitt ved medisinsk og kirurgisk intensiv avdeling ved UNN over en 2 års periode. Tross moderne behandling med bla tidlig revaskularisering døde ca 1/4 av pasientene under sykehusoppholdet. Dårligst prognose hadde de med kardiogent sjokk der nesten halvparten døde. De med lettere former for akutt hjertesvikt hadde meget dårlige leveutsikter i perioden etter utskrivelse og kun 50 % var i live etter to år. Mer utstrakt og tidlig bruk av mekanisk sirkulasjonsstøtte (hjertepumper) kan potensielt bedre overlevelsen hos de med mest alvorlig og behandlingsrefraktær hjertesvikt. Hos pasienter med kardiogent sjokk og alvorlig hjertesvikt etter hjertekirurgi er dårlig respons på konvensjonelle blodtrykksøkende medikamenter forbundet med spesielt dårlig prognose. For å kartlegge de underliggende mekanismene ved sirkulasjonssvikt spesielt mtp perifer sirkulasjonsregulering har vi målt perifer karfunksjon (endotelfunksjon), markører på systemisk inflammasjon og sirkulerende NO-blokkere (ADMA) under sykdomsforløpet. Tilstanden var karakterisert av en betydelig systemisk inflammasjon samt redusert perifer karfunksjon. Høye nivå av ADMA var assosiert med organsvikt og graden av hypoperfusjon. Description: The papers and the appendix of this thesis are not available in Munin:
1. Hermansen SE, Hansen M, Roaldsen M, Muller S, How OJ & Myrmel T.: 'Utilization and outcome of coronary revascularization and valve procedures in acute heart failure : an evaluation based on the classification from the European Society of Cardiology', Interactive CardioVascular and Thoracic Surgery (2008) vol.7, no.5:833-838. Available at http://dx.doi.org/10.1510/icvts.2008.175067
2. Hermansen SE, Hansen M, Roaldsen M, Muller S, How OJ & Myrmel T.: 'How many acute heart failure patients need a ventricular assist device?', Scandinavian Cardiovascular Journal (2008) vol.42, no.2:118-124. Available at http://dx.doi.org/10.1080/14017430701819113
3. Hermansen SE, Hansen M, Muller S, How OJ & Myrmel T.: 'Endothelial function during open heart surgery' (manuscript)
4. Hermansen SE, Kalstad T, How OJ & Myrmel T.: 'Inflammation and reduced endothelial function in the course of severe acute heart failure', Translational Research (2011) vol.157, no.3:117–127. Available at http://dx.doi.org/10.1016/j.trsl.2010.12.002
5. Hermansen SE, Lund T, Kalstad T, Ytrehus K & Myrmel T.: 'Adrenomedullin augments the angiogenic potential of late outgrowth endothelial progenitor cells', American Journal of Physiology Cell Physiology (2011) vol.300 no.4, C783-C791. Available at http://dx.doi.org/10.1152/ajpcell.00044.2010
Appendix: Hermansen SE, Naesheim T, How OJ & Myrmel T.: 'Circulatory assistance in acute heart failure : where do we go from here?', Scandinavian Cardiovascular Journal (2009) vol. 43, no.4:211-216. Available at http://dx.doi.org/10.1080/14017430802715962URI: http://hdl.handle.net/10037/4622 File(s) in this item: 1
thesis.pdf (1.140Mb) -
Deraas, Trygve S.; Giæver, Anton; Hansen, Vidje; Olstad, Reidun (Journal article; Tidsskriftartikkel; Peer reviewed, 29-Mar-2006)[+][-]
Abstract: Background: Over the last decades there has been an increasing pressure on the acute psychiatric wards in Norway. The major contributor to psychiatric acute admissions at the University Hospital of North Norway in the city of Tromsø in 2001 was the GP-based Tromsø Casualty Clinic, only open out-of-hours. We explored all acute psychiatric referrals from Tromsø Casualty Clinic in 2001. The purpose of the study was to characterize the admissions and assess the agreement between the referring doctors and the hospital specialists according to the need for hospitalization, agreement on application of the law and the diagnostic evaluation to assess whether the admissions were appropriate. Methods: Retrospective, record based, descriptive study comprising 101 psychiatric acute referrals from the Tromsø Casualty Clinic to the psychiatric acute wards at the University Hospital of North Norway. Results: The specialists accepted all referrals except one, they mostly agreed upon the diagnoses suggested by the referring doctors and they mostly confirmed the application of the law. Seventy-five percent of the admissions took place during weekends, public holidays or nighttimes. Diagnoses of psychoses or suicidal attempts accounted for 76 % of the total referrals. Substance abuse was noted for 43 %, and in 22 % of all admissions the patients had stopped taking their psychopharmacological medication. The police assisted the referring doctors in one third of all admissions, and was the legal representative in 52 out of 59 involuntary admissions. Thirty percent of the admissions were first- time admissions. Thirty-two percent of the hospital stays lasted for three days or less. Median length of stay was 6.5 days. Conclusion: The casualty clinic physicians and the hospital specialists mostly agreed in their evaluation of patients indicating that most of the admissions were appropriate. The police was more often involved in the involuntary admissions than intended in the law. The proportion of patients with substance abuse was significant. Alternative treatment strategies should be developed for non-psychotic patients in need of short-term stays. URI: http://hdl.handle.net/10037/1118 File(s) in this item: 1
article.pdf (270.2Kb) -
Rolfsen, Thomas (Master thesis; Mastergradsoppgave, 2003)[+][-]
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Holtmon, Mari (Master thesis; Mastergradsoppgave, 14-Oct-2004)[+][-]
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