Browsing Artikler, rapporter og annet (TMU) by Author "Tryland, Morten"
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Browsing Artikler, rapporter og annet (TMU) by Author "Tryland, Morten"
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Weli, Simon Chioma; Tryland, Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)[+][-]
Abstract: Avipoxviruses (APVs) belong to the Chordopoxvirinae subfamily of the Poxviridae family. APVs are distributed worldwide and cause disease in domestic, pet and wild birds of many species. APVs are transmitted by aerosols and biting insects, particularly mosquitoes and arthropods and are usually named after the bird species from which they were originally isolated. The virus species Fowlpox virus (FWPV) causes disease in poultry and associated mortality is usually low, but in flocks under stress (other diseases, high production) mortality can reach up to 50%. APVs are also major players in viral vaccine vector development for diseases in human and veterinary medicine. Abortive infection in mammalian cells (no production of progeny viruses) and their ability to accommodate multiple gene inserts are some of the characteristics that make APVs promising vaccine vectors. Although abortive infection in mammalian cells conceivably represents a major vaccine bio-safety advantage, molecular mechanisms restricting APVs to certain hosts are not yet fully understood. This review summarizes the current knowledge relating to APVs, including classification, morphogenesis, host-virus interactions, diagnostics and disease, and also highlights the use of APVs as recombinant vaccine vectors. URI: http://hdl.handle.net/10037/3922 File(s) in this item: 1
article.pdf (1.554Mb) -
Tryland, Morten; Okeke, Malachy Ifeanyi; Hård af Segerstad, Carl; Mörner, Torsten; Traavik, Ingemar Terje; Ryser-Degiorgis, Marie-Pierre (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)[+][-]
Abstract: Cowpox virus, which has been used to protect humans against smallpox but may cause severe disease in immunocompromised persons, has reemerged in humans, domestic cats, and other animal species in Europe. Orthopoxvirus (OPV) DNA was detected in tissues (lung, kidney, spleen) in 24 (9%) of 263 free-ranging Eurasian lynx (Lynx lynx) from Sweden. Thymidine kinase gene amplicon sequences (339 bp) from 21 lynx were all identical to those from cowpox virus isolated from a person in Norway and phylogenetically closer to monkeypox virus than to vaccinia virus and isolates from 2 persons with cowpox virus in Sweden. Prevalence was higher among animals from regions with dense, rather than rural, human populations. Lynx are probably exposed to OPV through predation on small mammal reservoir species. We conclude that OPV is widely distributed in Sweden and may represent a threat to humans. Further studies are needed to verify whether this lynx OPV is cowpox virus. URI: http://hdl.handle.net/10037/3897 File(s) in this item: 1
article.pdf (291.0Kb)
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