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Browsing Artikler, rapporter og annet (klinisk medisin) by Issue Date
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Helset, E.; Sildnes, T.; Seljelid, R.; Konopski, Z. S. (Journal article; Tidsskriftartikkel; Peer reviewed, 09-Sep-1993)[+][-]
Abstract: INCREASED plasma- and tissue levels of endothelin-1 (ET-1) during inflammatory diseases, have suggested a role of ET-1 in the pathophysiology of inflammatory reactions. The authors have studied the effect of ET-1 on cytokine release from monocytes and monocyte-derived macrophages. ET-1 increased secretion of TNF-α, IL-1β and IL-6 in a dose- and time-dependent manner. Optimal ET-1 concentration ranged from 0.01 to 1 nM. The maximal response was a 200 to 400% increase in cytokine release. A time-course study revealed that the pattern of cytokines induced by ET-1 was different in monocytes and macrophages, although an early increase in TNF-α was observed in both monocyte and macrophage supernatants. In conclusion, ET-1 stimulates monocytes and macrophages to release cytokines thereby demonstrating a potential role for ET-1 in regulation of inflammatory responses. URI: http://hdl.handle.net/10037/1706 File(s) in this item: 1
article.pdf (939.6Kb) -
Helset, E.; Sildnes, T.; Konopski, Z. S. (Journal article; Tidsskriftartikkel; Peer reviewed, 1994)[+][-]
Abstract: In the present study we examined whether endothelin-1 stimulation of human monocytes causes release of chemotactic factors. It was found that monocytes released neutrophil- and monocyte-chemotactic activity in a dose- and time-dependent manner in response to ET-1. ET-1 did not show any chemotactic activity by itself. NCA was detected in monocyte supernatants in response to ET-1 (0.01–100 nM) after 1, 4, 8 and 24 h stimulation. MCA was detected only after 24 h stimulation with ET-1 (0.1–100 nM). Preincubation of the monocyte cultures with the lipoxygenase inhibitors nordihydroguaiaretic acid (10−4 M) or diethylcarbamazine (10−9 M) completely abolished the appearance of NCA and MCA. NCA was neutralized by > 75% using a polyclonal antibody against human interleuktn-8. The ET-1 induced release of IL-8 was confirmed by IL-8 ELISA. A monoclonal antibody against human monocyte chemotactic protein-1 neutralized MCA by > 80%. It is concluded that ET-1 stimulation of monocytes in vitro causes release of neutrophil- and monocyte-chemotactic activity identified as IL-8 and MCP-I respectively. An intact lipoxygenase pathway is crucial for this effect of ET-1 to occur. URI: http://hdl.handle.net/10037/1700 File(s) in this item: 1
article.pdf (1.162Mb) -
Lappegård, Knut T.; Risøy, Bjørn Audun; Raastad, Truls; Hallén, Jostein; Bæverfjord, Kjersti; Kravdal, Astrid; Siebke, Else Marie; Benestad, Haakon B. (Journal article; Tidsskriftartikkel; Peer reviewed, 11-Dec-2003)[+][-]
Abstract: Background: During infections, polymorphonuclear neutrophilic granulocytes (PMN) are mobilized from their bone marrow stores, travel with blood to the affected tissue, and kill invading microbes there. The signal(s) from the inflammatory site to the marrow are unknown, even though a number of humoral factors that can mobilize PMN, are well known. We have employed a standardized, non-infectious human model to elucidate relevant PMN mobilizers. Well-trained athletes performed a 60-min strenuous strength workout of leg muscles. Blood samples were drawn before, during and just after exercise, and then repeatedly during the following day. Cortisol, GH, ACTH, complement factors, high-sensitive CRP (muCRP), IL-6, G-CSF, IL-8 (CXCL8) and MIP-1β (CCL4) were measured in blood samples. PMN chemotaxins in test plasma was assessed with a micropore membrane technique. Results: About 5 hr after the workout, blood granulocytosis peaked to about 150% of baseline. Plasma levels of GH increased significantly 30 min into and 5 min after the exercise, but no increase was recorded for the other hormones. No significant correlation was found between concentrations of stress hormones and the subjects' later occurring PMN increases above their individual baselines. Plasma G-CSF increased significantly – but within the normal range – 65 min after the workout. IL-6 increased very slightly within the normal range, and the chemokines IL-8 and MIP-1β did not increase consistently. However, we found a significant increase of hitherto non-identified PMN-chemotactic activity in plasma 35, 50, and 60 min after the exercise. No systemic complement activation was detected, and (mu)CRP was within the reference range at rest, 5 h and 23 h after the exercise. After endurance exercise, similar findings were made, except for a cortisol response, especially from non-elite runners. Conclusion: Apparently, a multitude of humoral factors can – directly or indirectly – mobilize PMN from marrow to blood; some of the factors are, others are not known to be, chemotactic. Under different conditions, different selections of these mobilizers may be used. In the late granulocytosis after heavy, long-lasting exercise a number of factors thought capable of mimicking the granulocytosis of infectious diseases were apparently irrelevant. URI: http://hdl.handle.net/10037/1142 File(s) in this item: 1
article.pdf (379.1Kb) -
Kirov, Mikhail Y.; Kuzkov, Vsevolod V.; Kuklin, Vladimir N.; Wærhaug, Kristine; Bjertnæs, Lars J. (Journal article; Tidsskriftartikkel; Peer reviewed, 19-Oct-2004)[+][-]
Abstract: Introduction: Acute lung injury is associated with accumulation of extravascular lung water (EVLW). The aim of the present study was to compare two methods for quantification of EVLW: transpulmonary single thermodilution (EVLWST) and postmortem gravimetric (EVLWG). Methods: Eighteen instrumented and awake sheep were randomly assigned to one of three groups. All groups received Ringer's lactate (5 ml/kg per hour intravenously). To induce lung injury of different severities, sheep received Escherichia coli lipopolysaccharide 15 ng/kg per min intravenously for 6 hours (n = 7) or oleic acid 0.06 ml/kg intravenously over 30 min (n = 7). A third group (n = 4) was subjected to sham operation. Haemodynamic variables, including EVLWST, were measured using a PiCCOplus monitor (Pulsion Medical Systems, Munich, Germany), and the last measurement of EVLWST was compared with EVLWG. Results: At the end of experiment, values for EVLWST (mean ± standard error) were 8.9 ± 0.6, 11.8 ± 1.0 and 18.2 ± 0.9 ml/kg in the sham-operated, lipopolysaccharide and oleic acid groups, respectively (P < 0.05). The corresponding values for EVLWIG were 6.2 ± 0.3, 7.1 ± 0.6 and 11.8 ± 0.7 ml/kg (P < 0.05). Ranges of EVLWIST and EVLWIG values were 7.5–21.0 and 4.9–14.5 ml/kg. Regression analysis between in vivo EVLWST and postmortem EVLWG yielded the following relation: EVLWST = 1.30 × EVLWG + 2.32 (n = 18, r = 0.85, P < 0.0001). The mean bias ± 2 standard deviations between EVLWST and EVLWG was 4.9 ± 5.1 ml/kg (P < 0.001). Conclusion: In sheep, EVLW determined using transpulmonary single thermodilution correlates closely with gravimetric measurements over a wide range of changes. However, transpulmonary single thermodilution overestimates EVLW as compared with postmortem gravimetry. URI: http://hdl.handle.net/10037/1129 File(s) in this item: 1
article.pdf (316.1Kb) -
Hamran, Torunn (Chapter; Bokkapittel, 2005)[+][-]
Abstract: I 1902 ble byen Narvik en realitet, og som så mange andre byer var veksten stor på den tiden. Byene i Norge økte ikke bare i areal og folketall, men også i sine velferdsproblemer. Hvordan Narvik fikk løst noen av oppgavene knyttet til helse og sykdom og hvem som gjorde hva innenfor kommunens grenser, er tema her. URI: http://hdl.handle.net/10037/1732 File(s) in this item: 1
article.pdf (105.8Kb) -
Ingebretsen, Ole C.; Kuklin, Vladimir N.; Kirov, Mikhail Y.; Sovershaev, Mikhail; Andreasen, Thomas; Ytrehus, Kirsti; Bjertnæs, Lars J. (Journal article; Tidsskriftartikkel; Peer reviewed, 04-Mar-2005)[+][-]
Abstract: Introduction: Studies in vitro reveal that endothelin-1 (ET-1) activates the α isoform of protein kinase C (PKC-α) in cultures of endothelial cells, thereby deranging cellular integrity. Sepsis and endotoxemia are associated with increased plasma concentrations of ET-1 that induce acute lung injury (ALI). We recently reported that non-selective ET-1 receptor blockade attenuates ALI in sheep by reducing the endotoxin-induced increase in extravascular lung water index (EVLWI). The aim of this study was to find out whether this attenuation is associated with reduced translocation of PKC-α from the cytosolic to the membrane fraction of lung tissue homogenate. Methods: Seventeen awake, instrumented sheep were randomly assigned to a sham-operated group (n = 3), a lipopolysaccharide (LPS) group (n = 7) receiving an intravenous infusion of Escherichia coli 15 ng/kg per min for 24 hours, and a tezosentan group (n = 7) subjected to LPS and, from 4 hours, an intravenous injection of tezosentan 3 mg/kg followed by infusion at 1 mg/kg per hour for the reminder of the experiment. Pulmonary micro-occlusion pressure (Pmo), EVLWI, plasma concentrations of ET-1, tumor necrosis factor-a (TNF-a), and interleukin-8 (IL-8) were determined every 4 hours. Western blotting was used to assess PKC-α. Results: In non-treated sheep a positive correlation was found between the plasma concentration of ET-1 and Pmo in the late phase of endotoxemia (12 to 24 hours). A positive correlation was also noticed between Pmo and EVLWI in the LPS and the LPS plus tezosentan groups, although the latter was significantly reduced in comparison with LPS alone. In both endotoxemic groups, plasma concentrations of ET-1, TNF-α, and IL-8 increased. In the LPS group, the cytosolic fraction of PKC-α decreased by 75% whereas the membrane fraction increased by 40% in comparison with the sham-operated animals. Tezosentan completely prevented the changes in PKC-α in both the cytosolic and the membrane fractions, concomitantly causing a further increase in the plasma concentrations of ET-1, TNF-α, and IL-8. Conclusion: In endotoxemic sheep, ET-1 receptor blockade alleviates lung injury as assessed by a decrease in EVLWI paralleled by a reduction in Pmo and the prevention of activation of PKC-α. URI: http://hdl.handle.net/10037/1128 File(s) in this item: 1
article.pdf (331.0Kb) -
Kuklin, Vladimir N.; Sovershaev, Mikhail; Andreasen, Thomas; Skogen, Vegard; Ytrehus, Kirsti; Bjertnæs, Lars J. (Journal article; Tidsskriftartikkel; Peer reviewed, 18-Oct-2005)[+][-]
Abstract: Introduction: We recently demonstrated that the non-selective endothelin-1 (ET-1) receptor blocker tezosentan antagonizes ovine acute lung injury (ALI) following infusion of endotoxin or ET-1 by reducing the enhanced lung microvascular pressure, although we could not exclude the possibility of a simultaneous decline in microvascular permeability. In the present study, our aim was to find out if tezosentan reverses the rise in microvascular filtration coefficient (Kfc) in rat lungs that have been isolated and perfused 12 h after cecum ligation and puncture (CLP) or infusion of ET-1. Methods: Wistar rats (n = 42) were subjected to CLP. Postoperatively, rats were randomized to a CLP group (n = 7) and a CLP + tezosentan group (n = 7); the latter received tezosentan 30 mg/kg. A sham-operated group (n = 5) underwent laparotomy without CLP. Twelve hours postoperatively, the lungs were isolated and perfused with blood from similarly treated rats that also were used to assess plasma concentration of ET-1 and protein kinase Cα (PKCα) in lung tissue. Additionally, isolated blood perfused lungs from healthy rats were randomized to a control group (n = 8), an ET-1 group (n = 7) subjected to pulmonary arterial injection of ET-1 10 nM, and an ET-1 + tezosentan group (n = 7) that received tezosentan 30 mg/kg. All lung preparations received papaverine 0.1 μg/kg added to the perfusate for vasoplegia. Pulmonary hemodynamic variables, Kfc and lung compliance (CL) were assessed. Results: After CLP, the plasma concentration of ET-1 increased. Papaverine abolished the vasoconstrictor response to ET-1 and the pulmonary vascular pressures remained close to baseline throughout the experiments. Both CLP and injection of ET-1 caused significant changes in Kfc and CL that were prevented in tezosentan-treated rats. Compared to sham-operated animals, CLP increased the content of PKCα by 50% and 70% in the cytosolic and the membrane fractions of lung tissue homogenates, respectively. Tezosentan prevented the upregulation of PKCα in the membrane fraction. Conclusion: In rat lungs isolated and perfused after CLP, tezosentan precludes both the increase in Kfc and the upregulation of PKCα in the membrane fraction of lung tissue. URI: http://hdl.handle.net/10037/1122 File(s) in this item: 1
article.pdf (461.8Kb) -
Aars, Marianne (Research report; Forskningsrapport, 2006)[+][-]
Abstract: Denne rapporten er basert på er et aksjonsrettet prosjekt som har involvert et (ut)forskende partnerskap mellom tre studenter, fem praksisveiledere og to lærere. Vi har hatt studentenes læring i fokus og fulgt ulike læringsaktiviteter på ulike læringsarenaer over en periode på 5 mnd. Det har vært lærerikt for oss alle. Vi har reflektert over studenters læring og gjennom det: over vår egen virksomhet og de ulike arenaers betydning for studenters læringsutbytte. URI: http://hdl.handle.net/10037/2267 File(s) in this item: 1
article.pdf (503.6Kb) -
Høifødt, Tordis Sørensen; Talseth, Anne-Grethe (Journal article; Tidsskriftartikkel; Peer reviewed, 2006)[+][-]
Abstract: Abstract Background Suicide is a major public health problem and treating suicidal patients represents one of the most challenging and complex clinical situations for young physicians. Education of physicians is considered an important strategy in suicide prevention. Young physicians often meet suicidal patients early in their career. Limited information is available about how newly educated physicians experience treating suicidal patients. The aim of the study was to shed light on the meaning of newly educated physicians´ lived experiences in treating patients at risk of committing suicide. Methods Thirteen newly educated physicians narrated their experiences with suicidal patients. The interview text was transcribed and interpreted using a phenomenological-hermeneutical method inspired by Ricoeur´s philosophy. Results Three main themes and ten themes were noted: Striving for relatedness: relating with the patient; not being able to relate with the patient; Intervening competently: having adequate professional knowledge; performing professionally; having professional values; evaluating one’s own competence; and Being emotionally involved: accepting one’s own vulnerability; feeling morally indignant; feeling powerless and accepting one’s own fallibility. The recently educated physicians clearly described the variety of emotional and ethical dilemmas that arose in meeting suicidal patients and the professional challenge facing this clinical situation. The findings were interpreted in the perspective of communication, clinical decision-making and attention to the professional’s emotional reactions. Conclusions An examination of the experiences of young physicians treating suicidal patients reveals three main themes that were a professional challenge for them: Striving for relatedness, Intervening competently and Being emotionally involved. Support for young practitioners that are treating these patients is likely important both to facilitate learning and also for their own well-being. This increased understanding can open up for the patient’s suffering and affirm the patient’s sense of life. The study provides additional background for educators designing training programs for physicians who will be treating suicidal patients. URI: http://hdl.handle.net/10037/3205 File(s) in this item: 1
article.pdf (272.1Kb) -
Jorde, Rolf (Journal article; Tidsskriftartikkel, 2006)[+][-]
Abstract: The objective of the present cross-sectional epidemiological study from Tromsø, North Norway was to evaluate the relation between blood pressure and serum parathyroid hormone (PTH). 10419 subjects were invited to participate in the fifth Tromsø study and 8128 attended. 7954 subjects had serum PTH measured, and among these, information on blood pressure medication was available in 5841 subjects (2554 males) with serum calcium within the reference range 2.20-2.60 mmol/L. In a multiple linear regression model with age, BMI, serum calcium, serum creatinine, and smoking status as covariables, serum PTH was a significant and positive predictor of systolic and diastolic blood pressure in both genders. When dividing the cohort in PTH quartiles, and adjusting for age, BMI, serum calcium, and serum creatinine, the differences between the lowest and highest PTH quartile in systolic and diastolic blood pressure were 5.0 and 3.5 mmHg for males and 4.1 and 2.5 mmHg for females, respectively. In previous studies we have found serum PTH to be a positive predictor for future increase in blood pressure, and also that the association between serum PTH and blood pressure cannot alone be ascribed to a blood pressure induced increase in urinary calcium excretion. To further elucidate the relation between serum PTH and blood pressure, randomized clinical trials with calcium and/or vitamin D supplementation to subjects with increased serum PTH levels are needed. URI: http://hdl.handle.net/10037/2415 File(s) in this item: 1
article.pdf (313.8Kb) -
Eriksen, Bjørn Odvar; Evensen, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2006)[+][-]
Abstract: Bakgrunn: Norsk medisinsk forskning hevder seg dårlig i nordisk sammenheng. Ved UniversitetssykehusetNord-Norge (UNN) ble forskningsaktivitet og hindringer for klinisk forskning undersøktmed en spørreskjemaundersøkelse i år 2000. Denne undersøkelsen er nå gjentatt etter fem år for å se omforholdene er endret.Materiale og metode: Alle leger og psykologer ved UNN fikk i mai 2005 tilsendt det samme spørreskjemaetsom ble brukt i år 2000.Resultater: Etter purring hadde 433 (82%) av 530 spurte svart. 48% deltok i et pågående forskningsprosjekt(38% i et prosjekt som kvalifiserte til medforfatterskap, 5% i et prosjekt initiert av industrien, 5% ibegge typer prosjekter). 22% av de spurte oppgav å ha doktorgrad, 28% hadde publisert i fagfellevurderttidsskrift uten å ha doktorgrad, mens 28% ikke hadde publisert i slike tidsskrifter. Av faktorersom hindret forskning eller økt forskningsaktivitet, angav 84% mangel på tid, 52% faktorer sompotensielt kunne avhjelpes av sykehusets apparat for forskningsstøtte og 35% andre faktorer. Uttrykt iprosentandeler var det små endringer i svarene i forhold til år 2000.Fortolkning: Det har ikke skjedd noen endring i andelen ansatte engasjert i forskning ved UNN fra2000 til 2005. Fortsatt oppleves mangel på tid som den viktigste hindringen for forskning. URI: http://hdl.handle.net/10037/3283 File(s) in this item: 1
article.pdf (417.3Kb) -
Elstad, Ingunn (Working paper; Arbeidsnotat, 2006)[+][-]
Abstract: The article explores the history of voluntary district nursing in Northern Norway 1880- 1940. A popular movement of women’s associations met the tuberculosis epidemic, which peaked late in the North. District nursing was developed partly from the European movement of Christian relief and sick care, partly from local traditions of neighbourly assistance. Local girls were trained and employed by local associations. This service was especially important to sick peasant women with families, as the nurses stayed in the homes during a crisis, and did the work that was needed as well as nursing. Between the wars, the international public health movement brought a focus on preventive public health nursing to the central leaders of the tuberculosis movement of Norway. Funds were made available to local associations, on condition that the nurse’s work was re-defined from sick care to public prevention, and directed by the medical officer. This medical corporativism was only partly successful, as sick nursing continued locally. District nursing in the North illustrates the central-local difference, the implicit gender issue, and the tension between sickness or health focus in the development of modern health care. Description: Dette er manus til den trykte artikkelen, den elektroniske utgaven kan derfor avvike fra den trykte utgaven i enkelte detaljer. URI: http://hdl.handle.net/10037/759 File(s) in this item: 1
article.pdf (67.20Kb) -
Olsen, Trine; Goll, Rasmus; Florholmen, Jon; Cui, Guanglin (Journal article; Tidsskriftartikkel; Peer reviewed, 03-Mar-2006)[+][-]
Abstract: Background In real-time PCR data analysis, the cycle threshold (CT) method is currently the gold standard. This method is based on an assumption of equal PCR efficiency in all reactions, and precision may suffer if this condition is not met. Nonlinear regression analysis (NLR) or curve fitting has therefore been suggested as an alternative to the cycle threshold method for absolute quantitation. The advantages of NLR are that the individual sample efficiency is simulated by the model and that absolute quantitation is possible without a standard curve, releasing reaction wells for unknown samples. However, the calculation method has not been evaluated systematically and has not previously been applied to a TaqMan platform. Aim: To develop and evaluate an automated NLR algorithm capable of generating batch production regression analysis. Results Total RNA samples extracted from human gastric mucosa were reverse transcribed and analysed for TNFA, IL18 and ACTB by TaqMan real-time PCR. Fluorescence data were analysed by the regular CT method with a standard curve, and by NLR with a positive control for conversion of fluorescence intensity to copy number, and for this purpose an automated algorithm was written in SPSS syntax. Eleven separate regression models were tested, and the output data was subjected to Altman-Bland analysis. The Altman-Bland analysis showed that the best regression model yielded quantitative data with an intra-assay variation of 58% vs. 24% for the CT derived copy numbers, and with a mean inter-method deviation of × 0.8. Conclusion NLR can be automated for batch production analysis, but the CT method is more precise for absolute quantitation in the present setting. The observed inter-method deviation is an indication that assessment of the fluorescence conversion factor used in the regression method can be improved. However, the versatility depends on the level of precision required, and in some settings the increased cost effectiveness of NLR may justify the lower precision. URI: http://hdl.handle.net/10037/1120 File(s) in this item: 1
article.pdf (420.2Kb) -
Kirov, Mikhail; Bjertnæs, Lars J.; Kuzkov, Vsevolod V.; Fernandez-Mondejar, Enrique (Journal article; Tidsskriftartikkel; Peer reviewed, 24-Jul-2006)[+][-]
Abstract: The evolution of extravascular lung water (EVLW) monitoring is an important step forward in the hemodynamic assessment of critically ill patients. URI: http://hdl.handle.net/10037/1109 File(s) in this item: 1
article.pdf (34.34Kb) -
Talseth, Anne-Grethe; Sørensen Høifødt, Tordis (Journal article; Tidsskriftartikkel; Peer reviewed, 23-Aug-2006)[+][-]
Abstract: Background: Suicide is a major public health problem and treating suicidal patients represents one of the most challenging and complex clinical situations for young physicians. Education of physicians is considered an important strategy in suicide prevention. Young physicians often meet suicidal patients early in their career. Limited information is available about how newly educated physicians experience treating suicidal patients. The aim of the study was to shed light on the meaning of newly educated physicians' lived experiences in treating patients at risk of committing suicide. Methods: Thirteen newly educated physicians narrated their experiences with suicidal patients. The interview text was transcribed and interpreted using a phenomenological-hermeneutical method inspired by Ricoeur's philosophy. Results: Three main themes and ten themes were noted: Striving for relatedness: relating with the patient; not being able to relate with the patient; Intervening competently: having adequate professional knowledge; performing professionally; having professional values; evaluating one's own competence; and Being emotionally involved: accepting one's own vulnerability; feeling morally indignant; feeling powerless and accepting one's own fallibility. The recently educated physicians clearly described the variety of emotional and ethical dilemmas that arose in meeting suicidal patients and the professional challenge facing this clinical situation. The findings were interpreted in the perspective of communication, clinical decision-making and attention to the professional's emotional reactions. Conclusion: An examination of the experiences of young physicians treating suicidal patients reveals three main themes that were a professional challenge for them: Striving for relatedness, Intervening competently and Being emotionally involved. Support for young practitioners that are treating these patients is likely important both to facilitate learning and also for their own wellbeing. This increased understanding can open up for the patient's suffering and affirm the patient's sense of life. The study provides additional background for educators designing training programs for physicians who will be treating suicidal patients. URI: http://hdl.handle.net/10037/1108 File(s) in this item: 1
article.pdf (272.1Kb) -
Becker-Merok, Andrea; Kalaaji, Manar; Haugbro, Kaia; Nikolaisen, Cathrin; Nilsen, Kirsten; Rekvig, Ole Petter; Nossent, Johannes C. (Journal article; Tidsskriftartikkel; Peer reviewed, 24-Oct-2006)[+][-]
Abstract: This study investigated the overall clinical impact of anti-α- actinin antibodies in patients with pre-selected autoimmune diseases and in a random group of anti-nuclear antibody (ANA)- positive individuals. The relation of anti-α-actinin antibodies with lupus nephritis and anti-double-stranded DNA (anti-dsDNA) antibodies represented a particular focus for the study. Using a cross-sectional design, the presence of antibodies to α-actinin was studied in selected groups, classified according to the relevant American College of Rheumatology classification criteria for systemic lupus erythematosus (SLE) (n = 99), rheumatoid arthritis (RA) (n = 68), Wegener's granulomatosis (WG) (n = 85), and fibromyalgia (FM) (n = 29), and in a random group of ANA-positive individuals (n = 142). Renal disease was defined as (increased) proteinuria with haematuria or presence of cellular casts. Sera from SLE, RA, and Sjøgren's syndrome (SS) patients had significantly higher levels of anti-α-actinin antibodies than the other patient groups. Using the geometric mean (± 2 standard deviations) in FM patients as the upper cutoff, 20% of SLE patients, 12% of RA patients, 4% of SS patients, and none of the WG patients were positive for anti-α- actinin antibodies. Within the SLE cohort, anti-α-actinin antibody levels were higher in patients with renal flares (p = 0.02) and correlated independently with anti-dsDNA antibody levels by enzyme-linked immunosorbent assay (p < 0.007) but not with other disease features. In the random ANA group, 14 individuals had anti-α-actinin antibodies. Of these, 36% had SLE, while 64% suffered from other, mostly autoimmune, disorders. Antibodies binding to α-actinin were detected in 20% of SLE patients but were not specific for SLE. They correlate with anti-dsDNA antibody levels, implying in vitro crossreactivity of anti-dsDNA antibodies, which may explain the observed association with renal disease in SLE. URI: http://hdl.handle.net/10037/1105 File(s) in this item: 1
article.pdf (273.7Kb) -
Lund, Niels W; Bellika, Johan G; Årsand, Eirik; Olsen, Bernt I; Hasvold, Per; Ellingsen, Gunnar; Horsch, Alexander; Hartvigsen, Gunnar (Chapter; Bokkapittel, 2007)[+][-]
Description: In: Roswitha Skare, Niels Windfeld Lund, Andreas Vårheim (eds.) (2007): "A Document (Re)turn". Frankfurt am Main, Peter Lang,pp. 95-116 Reprinted with permission.
This article is part of Bernt Ivar Olsen's doctoral thesis. Available in Munin at http://hdl.handle.net/10037/4774URI: http://hdl.handle.net/10037/974 File(s) in this item: 1
paper.pdf (2.996Mb) -
Krogstad, Unni; Gilbert, Mads; Ormstad, Sari Susanna; Rygh, Liv; Arntzen, Elisabeth; Baalsrud, Anders; Nilsen, Stein Tore (Research report; Forskningsrapport, 2007)[+][-]
Abstract: Helse Øst RHF har bedt Kunnskapssenteret om å vurdere dokumentasjonen for de seks satsingsområdene kampanjen fokuserer på: Etablere 'Rapid response team' (ekspertgruppe som tilkalles ved forverret tilstand hos pasienter) gjennomføre evidensbaserte behandlingstiltak for alle hjerteinfarktpasienter, forebygge legemiddelrelaterte pasientskader, forebygge postoperative sårinfeksjoner, forebygge respiratorassosierte lungebetennelse og forebygge alvorlige infeksjoner i forbindelse med sentralt venekateter."Pasientsikkerhet i sykehus – kunnskap eller kampanje?" (no english title) URI: http://hdl.handle.net/10037/3214 File(s) in this item: 1
article.pdf (595.7Kb) -
Elstad, Ingunn (Chapter; Bokkapittel, 2007)[+][-]
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Norderhaug, Inger Natvig; Ingebrigsten, Tor; Krogstad, Unni; Søreide, Odd; Myhre, Hans Olav; Wiseth, Rune (Research report; Forskningsrapport, 2007)[+][-]
Abstract: Kunnskapssenteret har gjennomgått og sammenstilt forskningen om pasientvolum og behandlingskvalitet med grunnlag i litteratur for perioden 2001–2006. Denne delrapporten tar for seg behandling av hjerte- og karsykdommer.The influence of hospital or physician volume on qality of health care URI: http://hdl.handle.net/10037/3215 File(s) in this item: 1
article.pdf (816.4Kb)
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