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Synthesis of thiol-appended gold and rhenium corroles as potential nanoconjugants for gold nanoparticles
(Master thesis; Mastergradsoppgave, 2023-06-10)Photodynamic therapy (PDT) today is an established treatment for a variety of cancers as well as various dermatological conditions, macular degeneration and bacterial and other infections. Treatment involves the administration of a photosensitizer, typically a porphyrin, followed by irradiation with light. The photoexcited sensitizer transfers its excess energy to oxygen in the affected tissue, ... -
The unique disulfide linked activation loop of DYRK kinases and possible redox activity control
(Master thesis; Mastergradsoppgave, 2022-06-15)The cysteine of HCD (C286) in DYRK1A is involved in disulfide bridge formation with a cysteine (C312) in the DFGSSC sequence. The purpose of this project was to investigate how the state of the disulfide bridge would affect enzyme catalytic and ligand binding properties of the protein kinase. A mutant, DYRK1A C312A, was thus designed to eliminate the disulfide bridge. The mutant was expressed and ... -
Structural and functional studies of Ectoine Synthase from Chromohalobacter salexigens DSM 3043 and Marinobacter sp. CK1
(Master thesis; Mastergradsoppgave, 2021-10-15)Ectoine is a compatible solute found in many microorganisms adapted to survive in saline and other extreme environments. Here, it aids microorganisms to counter osmotic stress and protect their enzymes. Ectoine exhibit many interesting properties that is potentially commercially exploitable, and it is currently produced and found in several products on the market. While ectoine is produced by ... -
Computer Simulation of Antimicrobial Agents
(Master thesis; Mastergradsoppgave, 2021-10-15)The last 18 months has shown the impact a single microorganism can have on society with the SARS-CoV-2 virus. This is not the only global threat on our health, with the World Health Organisation and other government agencies warning against the increase in antimicrobial resistance today. Antimicrobial peptides have been seen as a possible solution, as they are known to fight bacteria as a part of ... -
Exploring Palladium-Catalyzed Cross-Coupling at Nitrile Groups
(Master thesis; Mastergradsoppgave, 2022-05-16)Carbon-Carbon cross-coupling is a useful method that is used to connect carbons of different molecules to create a larger molecule. This is particularly powerful in synthesis of complicated molecules because it allows for different parts of the target molecule to be worked with separately before they are connected, which reduces the restrictions on the methods used during synthesis. One major drawback ... -
Synthesis of Potential Metallo-β-Lactamase Inhibitors
(Master thesis; Mastergradsoppgave, 2012-06-04)Oppgaven omhandler syntesen av mulige metallo-beta-lactamaser inhibitorer. -
Computer Modelling of an Enzyme Reference Reaction for Empirical Valence Bond Simulation
(Master thesis; Mastergradsoppgave, 2020-11-04)It is extensively recognized that an enzyme functions through reducing the energy of activation of its elemental reaction and the catalytic effect of an enzyme is as a result of a change in activation free energy obtained relative to a reference reaction in water of the same mechanism. In this study, chorismate mutase which is an enzyme that catalyzes biochemical reactions for chorismate conversion ... -
Antibiotic Resistance Breakers: Design and Synthesis of OXA-48 Inhibitors
(Master thesis; Mastergradsoppgave, 2020-06-01)Antibiotic resistance is threatening the achievements of modern medicine and will evidentially lead to a situation, in which we stand helpless against common bacterial infections. The largest and most widely used group of antibiotics are the β-lactams. One of the major resistance determinants against β-lactam antibiotics is the expression of hydrolytic enzymes, called β-lactamases (BLs). The main ... -
Adsorption of Organic Pollutants in Microplastic in the Arctic Ocean
(Master thesis; Mastergradsoppgave, 2019-05-15)Oceans all over the world are housing large quantities of plastic pollution and persistent organic pollutants (POPs). Concerns regarding both of them having lipophilic characteristic that allows a successful partitioning of POPs to plastic if in contact in an aqueous medium, led to this study where the relationship between different types of plastic and POPs in the Arctic ocean are looked into. In ... -
Novel Synthesis of Lipoxine A4 Analogues. Towards Allostric Modulators for Human Cannabinoid Receptor Type 1
(Master thesis; Mastergradsoppgave, 2015-11-15)The synthesis of the benzoid-based lipoxine A4 (LXA4) is the focus of this study specifically, the para substituted benzoid system. LXA4 is an endogenous agonist binding with high affinity to (ALXR) receptor that initiate it to display anti-inflammatory and antioxidant activities. Arachidonic acid is the cascade of LXA4 and its derivatives. These compounds belong to the biological active eicosanoids, ... -
Computational Studies of Selected Mutants of Shrimp Alkaline Phosphatase
(Master thesis; Mastergradsoppgave, 2020-06-01)Drug discovery and refinement for use in the industry is an important and lucrative field within chemistry. In this regard, computational chemistry has shown to be a valuable tool in assisting drug discovery. A set of intriguing proteins used in drug discovery are cold-adapted enzymes. These enzymes have a lower activation point which makes them of interest in industrial use. In this study, the ... -
Computer Simulations of Antimicrobial Tripeptides with Proteolytic Stability Towards Chymotrypsin
(Master thesis; Mastergradsoppgave, 2019-12-05)The emerging crisis of antimicrobial resistance calls for the development of new therapeutic drugs. Antimicrobial peptides (AMPs), found in a variety of species as part of the host-defence mechanisms, serves as promising candidates for clinical use. Studies of well-known AMPs like lactoferrin have lead to the preparation of short cationic AMPs (CAPs) with broad spectrum antimicrobial activity against ... -
Microwave-assisted synthesis of heterocycles from aryldiazoacetates.
(Master thesis; Mastergradsoppgave, 2017-11-15)A novel microwave-assisted method for generation of heterocycles have been explored. A range of 3,4 dihydroquinoxalin-2-ones have been prepared via an N-H insertion/cyclization cascade of dinucleophiles and aryldiazoacetates in moderate to good yields (12 - 80%). Reactions of aryldiazoacetates with o-phenylenediamine generated the best yields, while reactions with aliphatic and benzylic dinucleophiles ... -
Exploring N-nucleophiles for diversification of a complex cyclohexenone scaffold
(Master thesis; Mastergradsoppgave, 2019-06-05)In this thesis, synthesis of 3 different dibenzylideneacetone (DBA)-analogues and 4 different ethyl 2-oxo-6-phenyl-4-(2-phenylethenyl)-4-cyclohexene-1-carboxylate-analogues that have not been reported before were synthesized, as well as a range of analogues that have been reported before. Both symmetrical and unsymmetrical DBA-analogues were made. The yields of many of these reactions were low, but ... -
Structure activity investigations of XTH inhibitors
(Master thesis; Mastergradsoppgave, 2019-05-15)XTHs (xylogclucan endotransglucosylase/hydrolases) are a group of plant enzymes that regulate xyloglucan crosslinking in cell walls and play an essential role in regulation of plant growth. It is thought that XTHs play an integral role in the way the parasitic vine plant Cuscuta is able to penetrate host plant cell walls. Parasitic higher plants are a formidable threat to agricultural production ... -
Development of a novel method for the analysis of acyl carnitine profile using liquid chromatography mass spectrometry
(Master thesis; Mastergradsoppgave, 2019-05-15)Carnitine is a low-molecular-weight compound that has an obligate role in the mitochondrial oxidation of long-chain fatty acids (acyl groups) and energy production. Therefore, acylcarnitines are essential diagnostic markers for complex diseases, fatty acid metabolism disorders, and disorders related to amino acids metabolism. Biochemical screening of the acylcarnitine profile is performed in clinical ... -
Synthesis of XTH inhibitors
(Master thesis; Mastergradsoppgave, 2019-05-15)XTH er en gruppe enzymer som ble oppdaget tidlig på 90 tallet og muligens er involvert i Cuscuta infeksjonen av tomater. En nylig studie gjort ved arktisk og marin biologi UIT viser at Brilliant Blue R250 fungerer som en god inhibitor mot disse enzymene. I dette prosjektet ble det fokusert på å syntetisere strukturelt like molekyler for å potensielt øke vannløseligheten og inhibitoraktiviteten. ... -
Rhenium- and technetium-oxo corroles: Toward corrole-based drugs and radiopharmaceuticals.
(Master thesis; Mastergradsoppgave, 2017-11-15)Corroles are an important class of contracted porphyrin analogues. Since quasi-one-pot syntheses of corroles were first reported in 1999, their coordination chemistry has been extensively studied. In the course of this thesis, the “periodic table of corroles” has been extended by two new elements, rhenium and technetium. Except from an accidental synthesis of an ReVO corrole via ring contraction ... -
Synthesis of phorbazoles and breitfussins analogues
(Master thesis; Mastergradsoppgave, 2016-05-18)Breitfussins are a group of a closely related heterocyclic compounds. They consist of a tetracyclic structure with an indole, an oxazole and a pyrrole. The breitfussins exhibit interesting biological activity and analogues synthesis and biological evaluation is ongoing. Phorbazoles have a structural similarity with breitfussins in which a phenol replaces the indole. As a part of this, synthesis of ... -
Enzyme mechanism, thermostability, and structural studies of OXA-48 like carbapenemases involved in antibiotic resistance
(Master thesis; Mastergradsoppgave, 2018-05-15)Antibiotic resistance is being recognized as a world-wide crisis in modern medicine, rapidly outpacing available treatment options. The serine-beta-lactamase OXA-48 was first identified from a carbapenem- and multidrug- resistant Klebsiella pneumoniae isolate in Turkey in 2001, and is now one of the most geographically widespread members of the class D beta-lactamases. OXA-48 like beta-lactamases ...
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