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dc.contributor.authorFanidi, Anouar
dc.contributor.authorMuller, David C.
dc.contributor.authorMidttun, Øivind
dc.contributor.authorUeland, Per Magne
dc.contributor.authorVollset, Stein Emil
dc.contributor.authorRelton, Caroline
dc.contributor.authorVineis, Paolo
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorSkeie, Guri
dc.contributor.authorBrustad, Magritt
dc.contributor.authorPalli, Domenico
dc.contributor.authorTumino, Rosario
dc.contributor.authorGrioni, Sara
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorBueno-de-Mesquita, H. Bas
dc.contributor.authorPeeters, Petra H.
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorKvaskoff, Marina
dc.contributor.authorCadeau, Claire
dc.contributor.authorHuerta, José María
dc.contributor.authorSánchez, María-José
dc.contributor.authorAgudo, Antonio
dc.contributor.authorLasheras, Cristina
dc.contributor.authorQuirós, J. Ramón
dc.contributor.authorChamosa, Saioa
dc.contributor.authorRiboli, Elio
dc.contributor.authorTravis, Ruth C
dc.contributor.authorWard, Heather
dc.contributor.authorMurphy, Neil
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorLagiou, Pagona
dc.contributor.authorPapatesta, Eleni-Maria
dc.contributor.authorBoeing, Heiner
dc.contributor.authorKühn, Tilman
dc.contributor.authorKatzke, Verena
dc.contributor.authorSteffen, Annika
dc.contributor.authorJohansson, Anders
dc.contributor.authorBrennan, Paul
dc.contributor.authorJohansson, Mattias
dc.date.accessioned2017-02-22T10:24:56Z
dc.date.available2017-02-22T10:24:56Z
dc.date.issued2016-11-04
dc.description.abstractExperimental and epidemiological data suggest that vitamin D play a role in pathogenesis and progression of cancer, but prospective data on head and neck cancer (HNC) and oesophagus cancer are limited. The European Prospective Investigation into Cancer and Nutrition (EPIC) study recruited 385,747 participants with blood samples between 1992 and 2000. This analysis includes 497 case-control pairs of the head and neck and oesophagus, as well as 443 additional controls. Circulating 25(OH)D3 were measured in pre-diagnostic samples and evaluated in relation to HNC and oesophagus cancer risk and post-diagnosis all-cause mortality. After controlling for risk factors, a doubling of 25(OH) D3 was associated with 30% lower odds of HNC (OR 0.70, 95% confidence interval [95% CI] 0.56–0.88, Ptrend = 0.001). Subsequent analyses by anatomical sub-site indicated clear inverse associations with risk of larynx and hypopharynx cancer combined (OR 0.55, 95CI% 0.39–0.78) and oral cavity cancer (OR 0.60, 95CI% 0.42–0.87). Low 25(OH)D3 concentrations were also associated with higher risk of death from any cause among HNC cases. No clear association was seen with risk or survival for oesophageal cancer. Study participants with elevated circulating concentrations of 25(OH)D3 had decreased risk of HNC, as well as improved survival following diagnosis.en_US
dc.description.sponsorshipWorld Cancer Research Fund (UK) funded the biochemical analyses for the current study. The funding organization had no role in design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript. Dr Ueland reports that he is a member of the steering board of the nonprofit Foundation to Promote Research Into Functional Vitamin B12 Deficiency. No other disclosures were reported. The EPIC study has been supported by the Europe Against Cancer Program of the European Commission (SANCO); Deutsche Krebshilfe; Deutsches Krebsforschungszentrum; German Federal Ministry of Education and Research; Danish Cancer Society; Health Research Fund (FIS) of the Spanish Ministry of Health; Spanish Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra; Catalan Institute of Oncology, Spain; the ISCIII of the Spanish Ministry of Health (RETICC DR06/0020); Cancer Research UK; Medical Research Council, United Kingdom; Greek Ministry of Health; Stavros Niarchos Foundation; Hellenic Health Foundation; Italian Association for Research on Cancer (AIRC); Italian National Research Council; Fondazione-Istituto Banco Napoli, Italy; Associazione Italiana per la Ricerca sul Cancro- AIRC-Milan; Compagnia di San Paolo; Dutch Ministry of Public Health, Welfare and Sports; World Cancer Research Fund; Swedish Cancer Society; Swedish Scientific Council; Regional Government of Västerbotten, Sweden; NordForsk (Centre of excellence programme HELGA), Norway; French League against Cancer (LNCC), France; National Institute for Health and Medical Research (INSERM), France; Mutuelle Générale de l’Education Nationale (MGEN), France; 3M Co, France; Gustave Roussy Institute (IGR), France; and General Councils of France.en_US
dc.descriptionSource: <a href=http:dx.doi.org/10.1038/srep36017>doi: 10.1038/srep36017</a>en_US
dc.identifier.citationFanidi, A. et al. Circulating vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort. Sci. Rep. 6, 36017; doi: 10.1038/srep36017 (2016).en_US
dc.identifier.cristinIDFRIDAID 1414426
dc.identifier.doi10.1038/srep36017
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/10337
dc.language.isoengen_US
dc.publisherNature Publishing Groupen_US
dc.relation.journalScientific Reports
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.titleCirculating Vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohorten_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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