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dc.contributor.authorMcKenzie, Fiona
dc.contributor.authorBiessy, Carine
dc.contributor.authorFerrari, Pietro
dc.contributor.authorFreisling, Heinz
dc.contributor.authorRinaldi, Sabina
dc.contributor.authorChajes, Veronique
dc.contributor.authorDahm, Christina C
dc.contributor.authorOvervad, Kim
dc.contributor.authorDossus, Laure
dc.contributor.authorLagiou, Pagona
dc.contributor.authorTrichopoulos, Dimitrios
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorBas Bueno-De-Mesquita, H
dc.contributor.authorMay, Anne
dc.contributor.authorPeeters, Petra H
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorSanchez, Maria-Jose
dc.contributor.authorNavarro, Carmen
dc.contributor.authorArdanaz, Eva
dc.contributor.authorEricson, Ulrica
dc.contributor.authorWirfalt, Elisabet
dc.contributor.authorTravis, Ruth C
dc.contributor.authorRomieu, Isabelle
dc.date.accessioned2017-02-23T10:51:12Z
dc.date.available2017-02-23T10:51:12Z
dc.date.issued2016-04
dc.description.abstractIt has been estimated that at least a third of the most common cancers are related to lifestyle and as such are preventable. Key modifiable lifestyle factors have been individually associated with cancer risk; however, less is known about the combined effects of these factors. This study generated a healthy lifestyle index score (HLIS) to investigate the joint effect of modifiable factors on the risk of overall cancers, alcohol-related cancers, tobacco-related cancers, obesity-related cancers, and reproductive-related cancers. The study included 391,608 men and women from the multinational European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The HLIS was constructed from 5 factors assessed at baseline (diet, physical activity, smoking, alcohol consumption, and anthropometry) by assigning scores of 0 to 4 to categories of each factor, for which higher values indicate healthier behaviors. Hazard ratios (HR) were estimated by Cox proportional regression and population attributable fractions (PAFs) estimated from the adjusted models. There was a 5% lower risk (adjusted HR 0.952, 95% confidence interval (CI): 0.946, 0.958) of all cancers per point score of the index for men and 4% (adjusted HR 0.961, 95% CI: 0.956, 0.966) for women. The fourth versus the second category of the HLIS was associated with a 28% and 24% lower risk for men and women respectively across all cancers, 41%and 33%for alcohol-related, 49%and 46%for tobacco-related, 41% and 26% for obesity-related, and 21% for female reproductive cancers. Findings suggest simple behavior modifications could have a sizeable impact on cancer prevention, especially for men.en_US
dc.description.sponsorshipThe coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer (IARC).The national cohorts are supported by Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Generale de l’Education Nationale, Institut National de la Sante et de laRechercheMedicale (INSERM) (France); Deutsche Krebshilfe, Deutsches Krebsforschungszentrumand Federal Ministry of Education and Research (Germany); Hellenic Health Foundation (Greece); Italian Association for Research on Cancer (AIRC) and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds,DutchZON(ZorgOnderzoekNederland),WorldCancerResearch Fund(WCRF), Statistics Netherlands (TheNetherlands);ERC-2009-AdG 232997 and Nordforsk, Nordic Centre of Excellence Programmeon Food,Nutrition and Health. (Norway);Health Research Fund (FIS) of the Spanish Ministry of Health (ISCIII RETICC RD06/0020/0091), the Catalan Institute of Oncology, and the participating regional governments and institutions of Spain (Spain); Swedish Cancer Society, Swedish Scientific Council and Regional Government of Skane and Vasterbotten (Sweden); Cancer Research UK,Medical Research Council, Stroke Association, British Heart Foundation, Department of Health, Food Standards Agency, and Welcome Trust (United Kingdom).en_US
dc.descriptionSource: <a href=http://dx.doi.org/10.1097/MD.0000000000002850>doi: 10.1097/MD.0000000000002850</a>en_US
dc.identifier.citationMcKenzie F et.al.: Healthy lifestyle and risk of cancer in the European prospective investigation into cancer and nutrition cohort study. Medicine (Baltimore, Md.). 2016;95(16)en_US
dc.identifier.cristinIDFRIDAID 1366223
dc.identifier.doi10.1097/MD.0000000000002850
dc.identifier.issn0025-7974
dc.identifier.issn1536-5964
dc.identifier.urihttps://hdl.handle.net/10037/10349
dc.language.isoengen_US
dc.publisherLippincott, Williams & Wilkinsen_US
dc.relation.journalMedicine (Baltimore, Md.)
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.titleHealthy lifestyle and risk of cancer in the European prospective investigation into cancer and nutrition cohort studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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