Now showing items 1-6 of 6
Glomerular abundance of complement proteins characterized by proteomic analysis of laser-captured microdissected glomeruli associates with progressive disease in IgA nephropathy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-14)
Background: The clinical course of IgA nephropathy (IgAN) is variable and complement activation may predict prognosis. The present study investigated whether glomerular abundance of complement proteins associates with progression to end-stage renal disease (ESRD) in patients for whom prognosis could not be predicted based on clinical variables. <br> <br> Methods: Based on data from the Norwegian ...
The alternative complement pathway is dysregulated in patients with chronic heart failure
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-14)
The complement system, an important arm of the innate immune system, is activated in heart failure (HF). We hypothesized that HF patients are characterized by an imbalance of alternative amplification loop components; including properdin and complement factor D and the alternative pathway inhibitor factor H. These components and the activation product, terminal complement complex (TCC), were measured ...
Plasma complement and vascular complement deposition in patients with coronary artery disease with and without inflammatory rheumatic diseases
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-31)
Purpose: <br> Inflammatory rheumatic diseases (IRD) are associated with accelerated coronary artery disease (CAD), which may result from both systemic and vascular wall inflammation. There are indications that complement may be involved in the pathogenesis of CAD in Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA). This study aimed to evaluate the associations between circulating ...
Ficolins do not alter host immune responses to lipopolysaccharide-induced inflammation in vivo
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-20)
Ficolins are a family of pattern recognition molecules that are capable of activating the lectin pathway of complement. A limited number of reports have demonstrated a protective role of ficolins in animal models of infection. In addition, an immune modulatory role of ficolins has been suggested. Yet, the contribution of ficolins to inflammatory disease processes remains elusive. To address this, ...
Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-27)
Background<br> Fulminant meningococcal sepsis, characterized by overwhelming innate immune activation, mostly affects young people and causes high mortality. This study aimed to investigate the effect of targeting two key molecules of innate immunity, complement component C5, and co-receptor CD14 in the Toll-like receptor system, on the inflammatory response in meningococcal sepsis.<p> Methods ...
Impaired HDL function amplifies systemic inflammation in common variable immunodeficiency
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-01)
Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency, characterized by inadequate antibody responses and recurrent bacterial infections. Paradoxically, a majority of CVID patients have non-infectious inflammatory and autoimmune complications, associated with systemic immune activation. Our aim was to explore if HDL, known to have anti-inflammatory properties, ...