Now showing items 1-2 of 2
The alternative complement pathway is dysregulated in patients with chronic heart failure
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-14)
The complement system, an important arm of the innate immune system, is activated in heart failure (HF). We hypothesized that HF patients are characterized by an imbalance of alternative amplification loop components; including properdin and complement factor D and the alternative pathway inhibitor factor H. These components and the activation product, terminal complement complex (TCC), were measured ...
Impaired HDL function amplifies systemic inflammation in common variable immunodeficiency
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-01)
Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency, characterized by inadequate antibody responses and recurrent bacterial infections. Paradoxically, a majority of CVID patients have non-infectious inflammatory and autoimmune complications, associated with systemic immune activation. Our aim was to explore if HDL, known to have anti-inflammatory properties, ...