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Local In Time Statistics for detecting weak gene expression signals in blood – illustrated for prediction of metastases in breast cancer in the NOWAC Post-genome Cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-10)
Background: Functional genomics in a processual analysis cover the time-dependent changes in transcriptomics and epigenetics before diagnosis of a disease, reflecting the changes in both life style and disease processes. The aim of this paper is to explore the dynamic, time-dependent mechanisms of the metastatic processes, using blood transcriptomics and including time in a continuous manner. For ...
Osteoprotegerin and breast cancer risk by hormone receptor subtype: A nested case-control study in the EPIC cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-08)
Background:<br>Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Circulating OPG and breast cancer risk has been examined in only one prior study.<br>Methods:<br>A case-control ...
Use of hormonal contraceptives and occurrence of pregnancy-related pelvic pain. A prospective cohort study in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2004-06-22)
Background:
Pregnancy-related pelvic pain is a common condition, and use of hormonal contraceptives before pregnancy has been proposed as a risk factor. We used data from a sub-sample of women participating in the "Norwegian Women and Cancer study" (NOWAC) to assess the association between hormonal contraceptive use and pelvic pain in pregnancy.
Methods:
From a sub-group of 2078 parous women ...
Test-retest reproducibility of a food frequency questionnaire (FFQ) and estimated effects on disease risk in the Norwegian Women and Cancer Study (NOWAC)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-01-31)
Background:
The Norwegian Women and Cancer Study (NOWAC) is a national population-based cohort study with 102 443 women enrolled at age 30–70 y from 1991 to 1997. The present study was a methodological sub-study to assess the test-retest reproducibility of the NOWAC food frequency questionnaire (FFQ), and to study how measurement errors in the data can affect estimates of disease risk.
Methods:
A ...
A comprehensive analysis of the androgen receptor gene and risk of breast cancer. Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-09-20)
Introduction
Androgens have been hypothesised to influence risk of breast cancer through several possible mechanisms, including their conversion to estradiol or their binding to the oestrogen receptor and/or androgen receptor (AR) in the breast. Here, we report on the results of a large and comprehensive study of the association between genetic variation in the AR gene and risk of breast cancer ...
Lung cancers attributable to environmental tobacco smoke and air pollution in non-smokers in different European countries : a prospective study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2007-02-15)
Background: Several countries are discussing new legislation on the ban of smoking in public
places, and on the acceptable levels of traffic-related air pollutants. It is therefore useful to estimate
the burden of disease associated with indoor and outdoor air pollution.
Methods: We have estimated exposure to Environmental Tobacco Smoke (ETS) and to air
pollution in never smokers and ex-smokers ...
DNA methylation changes measured in pre-diagnostic peripheral blood samples are associated with smoking and lung cancer risk
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-15)
DNA methylation changes are associated with cigarette smoking. We used the Illumina Infinium HumanMethylation450 array to determine whether methylation in DNA from pre‐diagnostic, peripheral blood samples is associated with lung cancer risk. We used a case‐control study nested within the EPIC‐Italy cohort and a study within the MCCS cohort as discovery sets (a total of 552 case‐control pairs). We ...
A comprehensive assessment of fish and other seafood in the Norwegian diet
(Research report; Forskningsrapport, 2006-03-27)
At the request of the Norwegian Food Safety Authority, the Norwegian Scientific Committee for Food Safety (VKM) has conducted an assessment of the nutritional benefits of consuming fish and other seafood, compared with the health risks associated with the intake of contaminants and other undesirable compounds that fish and other seafood may contain.
Gene expression analyses in breast cancer epidemiology: the Norwegian Women and Cancer postgenome cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008-02-13)
Introduction:
The introduction of high-throughput technologies, also called -omics technologies, into epidemiology has raised the need for high-quality observational studies to reduce several sources of error and bias.
Methods:
The Norwegian Women and Cancer (NOWAC) postgenome cohort study consists of approximately 50,000 women born between 1943 and 1957 who gave blood samples between 2003 ...
Modifiable causes of premature death in middle-age in Western Europe: Results from the EPIC cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-14)
Background<br>
Life expectancy is increasing in Europe, yet a substantial proportion of adults still die prematurely before the age of 70 years. We sought to estimate the joint and relative contributions of tobacco smoking, hypertension, obesity, physical inactivity, alcohol and poor diet towards risk of premature death.<br>
Methods<br>
We analysed data from 264,906 European adults from the ...