• Coffee consumption and the risk of Venous Thromboembolism – The Tromsø study 

      Enga, Kristin (Master thesis; Mastergradsoppgave, 2011-11-01)
      Background: Several studies have investigated the association between coffee consumption and cardiovascular disease, but little is known about coffee intake and risk of venous thromboembolism (VTE). Objective: The aim of this prospective cohort study was to investigate the association between coffee consumption and risk of incident VTE in a general population. Methods: Information about coffee ...
    • Alcohol consumption, types of alcoholic beverages and risk of Venous Thromboembolism : the Tromsø Study 

      Hansen-Krone, Ida Johanne; Brækkan, Sigrid K.; Enga, Kristin F.; Wilsgaard, Tom; Hansen, John-Bjarne (Master thesis; Mastergradsoppgave, 2011-11-01)
      Moderate alcohol consumption has been shown to protect against cardiovascular diseases. The association between alcohol consumption, especially types of alcoholic beverages, and venous thromboembolism (VTE) is less well described. The aim of this study was to investigate the impact of alcohol consumption and different alcoholic beverages on risk of VTE. Information on alcohol consumption were ...
    • CGG-repeat length threshold for FMR1 RNA pathogenesis in a cellular model for FXTAS 

      Hoem, Gry (Master thesis; Mastergradsoppgave, 2013-10-18)
      Fragilt X-assosiert tremor/ataksi syndrom (FXTAS) er en neurodegenerativ sykdom som affekterer bærere av premutasjons-alleler (55-200 CGG repetisjoner) i ”fragile X mental retardation 1” (FMR1) genet. Hos premutasjonsbærere finne man økte mengder ekspandert mRNA , som er antatt å danne basis for patogenesen i FXTAS. Gjennom hvilke mekanismer mRNA forårsaker toksisitet er imidlertid ikke kjent. Det ...
    • Possible origin of a vanB-type Enterococcus faecium causing a multicentre outbreak in Sweden 

      Sivertsen, Audun (Master thesis; Mastergradsoppgave, 2013-11-01)
      Dissemination of vancomycin-resistant Enterococcus faecium (VREfm) with similar pulsed-field gel electrophoresis patterns in three Swedish hospitals between 2007 and 2011 prompted molecular characterization to reveal the possible origins and features of the strain. A representative subset of collected isolates (VREfm (n=18) and vancomycin-susceptible Enterococcus faecium (VSEfm) (n=2)) reflecting ...
    • Hepatic steatosis detected by ultrasonography as a predictor of insulin resistance in obese patients 

      Isaksen, Victoria Therese (Master thesis; Mastergradsoppgave, 2014-10-31)
      Non-alcoholic fatty liver disease is closely related to the Metabolic syndrome. A significant feature of NAFLD is the presence of hepatic steatosis, which can be assessed by ultrasonography, by measuring the hepatorenal index (HRI), a comparison of liver and kidney acoustic echo densities. This study aims to investigate if HRI can predict insulin resistance. Ninety participants from the obesity ...
    • Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism -The Tromsø Study 

      Lerstad, Gunhild (Master thesis; Mastergradsoppgave, 2015-10-23)
      Background: Glycated hemoglobin (HbA1c), a marker of average plasma glucose during the last 8-12 weeks, is associated with future risk of cardiovascular disease (CVD) and all-cause mortality. Objectives: To examine the association between hyperglycemia, assessed by HbA1c, and future risk of VTE in a population based cohort. Methods: HbA1c was measured in 16 156 unique subjects (25-87 years) ...
    • Impact of incident venous thromboembolism on risk of arterial thrombotic diseases 

      Lind, Caroline (Master thesis; Mastergradsoppgave, 2015-10-26)
      Background: Growing evidence support an association between venous thromboembolism (VTE) and arterial thrombotic diseases (i.e. myocardial infarction (MI) and ischemic stroke). We aimed to study the association between VTE and future arterial events, and to determine the population attributable risk (PAR%) of arterial events by VTE in a large prospective cohort recruited from the general ...
    • Prognostic impact of CXCL16 and CXCR6 in non-small cell lung cancer: combined high CXCL16 expression in tumor stroma and cancer cells yields improved survival 

      Hald, Sigurd M.; Kiselev, Yury; Al-Saad, Samer; Richardsen, Elin; Johannessen, Charles; Eilertsen, Marte; Kilvær, Thomas K.; Al-Shibli, Khalid; Andersen, Sigve; Busund, Lill-Tove; Bremnes, Roy M.; Dønnem, Tom (Master thesis; Mastergradsoppgave, 2015-10-27)
      BACKGROUND: The chemokine CXCL16 and its receptor CXCR6 are expressed by a variety of immune cells and have been shown to influence angiogenesis. The expression of CXCR6 and CXCL16 has been examined in numerous human cancers; however no studies have yet investigated their influence on prognosis in non-small cell lung cancer (NSCLC). We aimed to explore their prognostic significance in NSCLC, in ...
    • Serum free and bio-available 25-hydroxyvitamin D correlate better with bone density than serum total 25-hydroxyvitamin D 

      Johnsen, Martin Solvang (Master thesis; Mastergradsoppgave, 2015-10-29)
      Introduction/background In the circulation 25-hydroxyvitamin D (25(OH)D) is bound to vitamin D-binding protein (DBP) and albumin. Only a small fraction is in the unbound, free form. According to the ‘free-hormone-hypothesis’ only the free form is biologically active. Genetic differences in DBP may affect the binding to 25(OH)D and thereby the amount of free 25(OH)D. Methods In the present study ...
    • Estrogen receptors α and β and aromatase as independent predictors for prostate cancer outcome 

      Grindstad, Thea Karoline Walstad (Master thesis; Mastergradsoppgave, 2016-10-11)
      Androgens are considered important in normal prostate physiology and prostate cancer (PCa) pathogenesis. However, androgen-targeted treatment preventing PCa recurrence is still lacking. This indicates additional mediators contributing to cancer development. We sought to determine the prognostic significance of estrogen receptors, ERα and -β, and the aromatase enzyme in PCa. Tissue microarrays ...
    • Ischemic stroke and risk of venous thromboembolism in the general population. The Tromsø study 

      Rinde, Ludvig Balteskard (Master thesis; Mastergradsoppgave, 2017-10-21)
      Background: Even though clinical data support a relation between ischemic stroke and venous thromboembolism (VTE), the strength and time dependence of the association remain to be settled at the population level. We therefore aimed to investigate the association between ischemic stroke and VTE in a prospective population-based cohort. Methods and Results: Participants (n=30 002) were recruited from ...