Blar i forfatter Artikler, rapporter og annet (Norges fiskerihøgskole) "Jaspars, Marcel"

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    • Discovery and structural assignment of (S)-sydosine from amphipod-derived Aspergillus sydowii MBC15-11F through HRMS, advanced Mosher, and molecular modelling analyses 

      Qader, Mallique; Mweetwa, Larry L; Rämä, Teppo; Thissera, Bathini; Milne, Bruce F; Abdelmohsen, Usama R; Orfali, Raha; Tawfike, Ahmed; Esheli, Manal; Oluwabusola, Emmanuel T; Jaysainghe, Lalith; Jaspars, Marcel; Rateb, Mostafa E (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-21)
      Aims - This study aims to prioritize fungal strains recovered from under-explored habitats that produce new metabolites. HRMS dereplication is used to avoid structure redundancy, and molecular modelling is used to assign absolute configuration.<p> <p>Methods and results - MBC15-11F was isolated from an amphipod and identified using ITS, 28S, and β-tubulin phylogeny as Aspergillus sydowii. Chemical ...

    • Isolation and Synthesis of Pulmonarins A and B, Acetylcholinesterase Inhibitors from the Colonial Ascidian Synoicum pulmonaria 

      Tadesse, Margey; Svenson, Johan; Sepcič, Kristina; Trembleau, Laurent; Engqvist, Stig Olov Magnus; Andersen, Jeanette Hammer; Jaspars, Marcel; Stensvåg, Klara; Haug, Tor (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-02-14)
      Pulmonarins A and B are two new dibrominated marine acetylcholinesterase inhibitors that were isolated and characterized from the sub-Arctic ascidian <i>Synoicum pulmonaria</i> collected off the Norwegian coast. The structures of natural pulmonarins A and B were tentatively elucidated by spectroscopic methods and later verified by comparison with synthetically prepared material. Both pulmonarins A ...

    • The marine biodiscovery pipeline and ocean medicines of tomorrow 

      Jaspars, Marcel; de Pascale, Donatella; Andersen, Jeannette Hammer; Reyes, Fernando; Crawford, Alex D.; Ianora, Adrianna (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-01)
      Marine organisms possess the capacity to produce a variety of unique and biologically potent natural products for treating human diseases, many of which are currently commercially available or are in advanced clinical trials. Here we provide a short review on progress in the field and discuss a case study of an EU-funded project, PharmaSea, which aims to discover novel products for the treatment of ...