• B-1 plasma cells require non-cognate CD4 T cell help to generate a unique repertoire of natural IgM 

      Jensen, Ingvill (Journal article; Tidsskriftartikkel; Peer reviewed, 2023)
      Evolutionarily conserved, “natural” (n)IgM is broadly reactive to both self and foreign antigens. Its selective deficiency leads to increases in autoimmune diseases and infections. In mice, nIgM is secreted independent of microbial exposure to bone marrow (BM) and spleen B-1 cell–derived plasma cells (B-1PC), generating the majority of nIgM, or by B-1 cells that remain non-terminally differentiated ...
    • Detection of specific Atlantic salmon antibodies against salmonid alphavirus using a bead-based immunoassay 

      Teige, Lena Hammerlund; Aksnes, Ida; Røsæg, Magnus Vikan; Jensen, Ingvill; Jørgensen, Jorunn; Sindre, Hilde; Collins, Catherine; Collet, Bertrand; Rimstad, Espen; Dahle, Maria; Boysen, Preben (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-30)
      Salmonid alphavirus (SAV) is the etiological cause of pancreas disease (PD) in Atlantic salmon (<i>Salmo salar</i>). Several vaccines against SAV are in use, but PD still cause significant mortality and concern in European aquaculture, raising the need for optimal tools to monitor SAV immunity. To monitor and control the distribution of PD in Norway, all salmonid farms are regularly screened for SAV ...
    • Differences in smolt status affect the resistance of Atlantic salmon (Salmo salar L.) against infectious pancreatic necrosis, while vaccine-mediated protection is unaffected 

      Jensen, Ingvill; Overrein, Mathias; Fredriksen, Børge Nilsen; Strandskog, Guro; Seternes, Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-18)
      In today's aquaculture of Atlantic salmon (<i>Salmo salar</i> L.), a majority of viral disease outbreaks occur after seawater transfer. A relevant question is how the parr–smolt transformation influences the efficacy of viral vaccines and the innate resistance against viral diseases. In this study, vaccinated and unvaccinated A. salmon parr were exposed to different photoperiodic regimens (1‐, 3‐ ...
    • The importance of the Atlantic salmon peritoneal cavity B cell response: Local IgM secreting cells are predominant upon Piscirickettsia salmonis infection 

      van der Wal, Yorick Andreas; Jenberie, Shiferaw; Nordli, Henriette; Greiner-Tollersrud, Linn; Kool, Jaap; Jensen, Ingvill; Jørgensen, Jorunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-01)
      The intraperitoneal route is favored for administration of inactivated and attenuated vaccines in Atlantic salmon. Nevertheless, the immune responses in the teleost peritoneal cavity (PerC) are still incompletely defined. In this study, we investigated the B cell responses after intraperitoneal Piscirickettsia salmonis (P. salmonis) challenge of Atlantic salmon, focusing on the local PerC response ...
    • Infection and microbial molecular motifs modulate transcription of the interferon-inducible gene ifit5 in a teleost fish 

      Bela-Ong, Dennis; Greiner-Tollersrud, Linn; van der Wal, Yorick Andreas; Jensen, Ingvill; Seternes, Ole Morten; Jørgensen, Jorunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-21)
      Interferon-induced proteins with tetratricopeptide repeats (IFITs) are involved in antiviral defense. Members of this protein family contain distinctive multiple structural motifs comprising tetratricopeptides that are tandemly arrayed or dispersed along the polypeptide. IFIT-encoding genes are upregulated by type I interferons (IFNs) and other stimuli. IFIT proteins inhibit virus replication by ...
    • Intracellular distribution and transcriptional regulation of Atlantic salmon (Salmo salar) Rab5c, 7a and 27a homologs by immune stimuli 

      Nepal, Arpita; Wolfson, Deanna; Ahluwalia, Balpreet Singh; Jensen, Ingvill; Jørgensen, Jorunn B; Iliev, Dimitar Borisov (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-31)
      Rab GTPases control trafficking of intracellular vesicles and are key regulators of endocytic and secretory pathways. Due to their specific distribution, they may serve as markers for different endolysosomal compartments. Since Rab GTPases are involved in uptake and trafficking of endocytosed ligands and cell receptors, as well as secretion of immune mediators, they have been implicated in diverse ...
    • Microbial danger signals control transcriptional induction of distinct MHC class I L lineage genes in Atlantic salmon 

      Svenning, Steingrim; Gondek-Wyrozemska, Agata T; van der Wal, Yorick Andreas; Robertsen, Børre; Jensen, Ingvill; Jørgensen, Jorunn B; Edholm, Eva-Stina Isabella (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-11)
      Antigen processing and presentation by major histocompatibility complex (MHC) molecules is a cornerstone in vertebrate immunity. Like mammals, teleosts possess both classical MHC class I and multiple families of divergent MHC class I genes. However, while certain mammalian MHC class I-like molecules have proven to be integral in immune regulation against a broad array of pathogens, the biological ...
    • Profiling Atlantic salmon B cell populations: CpG-mediated TLR-ligation enhances IgM secretion and modulates immune gene expression 

      Jenberie, Shiferaw; Thim, Hanna Leena; Sunyer, J Oriol; Skjødt, Karsten; Jensen, Ingvill; Jørgensen, Jorunn B (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-23)
      While TLR-activated pathways are key regulators of B cell responses in mammals, their impact on teleost B cells are scarcely addressed. Here, the potential of Atlantic salmon B cells to respond to TLR ligands was shown by demonstrating a constitutive expression of nucleic-acid sensing TLRs in magnetic sorted IgM<sup>+</sup> cells. Of the two receptors recognizing CpG in teleosts, <i>tlr9</i> was the ...
    • Profiling the Atlantic Salmon IgM+ B Cell Surface Proteome: Novel Information on Teleost Fish B Cell Protein Repertoire and Identification of Potential B Cell Markers 

      Penaranda, Ma Michelle Demogina; Jensen, Ingvill; Tollersrud, Linn G.; Bruun, Jack-Ansgar; Jørgensen, Jorunn B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-29)
      Fish immunology research is at a pivotal point with the increasing availability of functional immunoassays and major advances in <i>omics</i> approaches. However, studies on fish B cells and their distinct subsets remain a challenge due to the limited availability of differentially expressed surface markers. To address this constraint, cell surface proteome of Atlantic salmon IgM<sup>+</sup> B cells ...
    • Salmonid Alphavirus Subtype 3 Induces Prolonged Local B Cell Responses in Atlantic Salmon (Salmo salar) After Intraperitoneal Infection 

      Jenberie, Shiferaw; Penaranda, Ma Michelle Demogina; Thim, Hanna Leena; Styrvold, Morten Bay; Strandskog, Guro; Jørgensen, Jorunn B; Jensen, Ingvill (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-10)
      B cell responses are a crucial part of the adaptive immune response to viral infection. Infection by salmonid alphavirus subtype 3 (SAV3) causes pancreas disease (PD) in Atlantic salmon (<i>Salmo salar</i>) and is a serious concern to the aquaculture industry. In this study, we have used intraperitoneal (IP) infection with SAV3 as a model to characterize local B cell responses in the peritoneal ...