Blar i utgivelsesdato Artikler, rapporter og annet (farmasi)

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    • Increasing mortality in schizophrenia: Are women at particular risk? A follow-up of 1111 patients admitted during 1980-2006 in Northern Norway 

      Høye, Anne; Jacobsen, Bjarne Koster; Hansen, Vidje (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      A study of mortality for all patients with schizophrenia admitted to the University Hospital of North Norway during 1980-2006 was performed, with a special focus on gender differences and changes in mortality during a period of transition from hospital-based to community-based care. A total of 1111 patients with schizophrenia were included, and the cohort was linked to the Causes of Death Register ...

    • Ultrasound-mediated destabilization and drug release from liposomes comprising dioleoylphosphatidylethanolamine 

      Evjen, Tove Julie; Nilssen, Esben A.; Barnert, Sabine; Schubert, Rolf; Brandl, Martin; Fossheim, Sigrid L (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Novel sonosensitive doxorubicin-containing liposomes comprising dioleoylphosphatidylethanolamine (DOPE) as the main lipid constituent were developed and characterized in terms of ultrasound-mediated drug release in vitro. The liposome formulation showed high sonosensitivity; where approximately 95% doxorubicin was released from liposomes after 6 min of 40 kHz US exposure in buffered sucrose solution. ...

    • Uptake and organ distribution of feed introduced plasmid DNA in growing or pregnant rats 

      Grønsberg, Idun; Nordgård, Lise; Fenton, Kristin Andreassen; Hegge, Beate; Nielsen, Kaare Magne; Bardocz, Susan; Pusztai, Arpad; Traavik, Ingemar Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)

    • Mucoadhesive liposomal delivery systems : the choice of coating material 

      Karn, Pankaj Ranjan; Vanic, Zeljka; Pepic, Ivan; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Development of liposomal mucoadhesive drug delivery system, which is able to improve the bioavailability of poorly absorbed oral drugs by prolonging their gastric and intestinal residence time, through facilitating the intimate contact of the delivery system with the absorption membrane. Liposomes containing model drug atenolol were prepared by the modified ethanol injection method. Liposomes ...

    • Risk of diabetes after gestational diabetes and preeclampsia : a registry-based study of 230,000 women in Norway 

      Engeland, Anders; Bjørge, Tone; Daltveit, Anne Kjersti; Skurtveit, Svetlana; Vangen, Siri; Vollset, Stein Emil; Furu, Kari (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      This study aimed to use a population-based Prescription Database to explore later development of diabetes in women registered with gestational diabetes mellitus (GDM) and/or preeclampsia in the Medical Birth Registry of Norway (MBRN) during 2004–8. We used two nationwide Norwegian registries, the Norwegian Prescription Database and the MBRN, to explore the onset of later diabetes after pregnancy ...

    • Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment 

      Basnet, Purusotam; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Oxidative damage and inflammation have been pointed out in preclinical studies as the root cause of cancer and other chronic diseases such as diabetes, hypertension, Alzheimer’s disease, etc. Epidemiological and clinical studies have suggested that cancer could be prevented or significantly reduced by treatment with anti-oxidant and anti-inflammatory drugs, therefore, curcumin, a principal component ...

    • Sonosensitive dioleoylphosphatidylethanolamine-containing liposomes with prolonged blood circulation time of doxorubicin 

      Evjen, Tove Julie; Brandl, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Ultrasound sensitive (sonosensitive liposomes) are drug delivery systems designed for releasing their drug load upon exposure to ultrasound (US). Inclusion of dioleoylphosphatidylethanolamine (DOPE) in liposome membranes was previously shown to induce sonosensitivity. For efficient US mediated drug delivery to solid tumours, a long blood circulation time of the liposomal drug providing high tumour ...

    • Retrospective evidence for a biological cost of vancomycin resistance determinants in the absence of glycopeptide selective pressures 

      Johnsen, Pål jarle; Townsend, JP; Bøhn, Thomas; Simonsen, Gunnar Skov; Sundsfjord, arnfinn; Nielsen, Kaare Magne (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      To estimate the relative fitness differences between glycopeptide-resistant Enterococcus faecium (GREF) and glycopeptide-susceptible E. faecium (GSEF) from yearly surveillance data on the occurrence of GREF in Danish poultry farm environments. A population genetic model was adapted to retrospectively estimate the biological fitness cost of acquired resistance. Maximization of a likelihood function ...

    • Comorbidities in an asthma population 8-29 years old: a study from the Norwegian Prescription Database 

      Karlstad, Øystein; Nafstad, Per; Tverdal, Aage; Skurtveit, Svetlana; Furu, Kari (Journal article; Tidsskriftartikkel; Peer reviewed, 2011-09-23)
      Purpose: To examine occurrence of chronic diseases and antimicrobial treatment in an asthma population 8-29 years old, compared to the general population. Methods: In this cross-sectional study, the asthma population was identified from the general population (retrieved from a census covering the entire Norwegian population) by using filled prescriptions on asthma drugs as a proxy measure of ...

    • The German ban on GM maize MON810: scientifically justified or unjustified? 

      Bøhn, Thomas; Primicerio, Raul; Traavik, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)

    • Assessing the probability of detection of horizontal gene transfer events in bacterial populations 

      Townsend, Jeffrey P.; Bøhn, Thomas; Nielsen, Kaare Magne (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Experimental approaches to identify horizontal gene transfer (HGT) events of non-mobile DNA in bacteria have typically relied on detection of the initial transformants or their immediate offspring. However, rare HGT events occurring in large and structured populations are unlikely to be detected in a short time frame. Population genetic modeling of the growth dynamics of bacterial genotypes is ...

    • Expression of S100A4, ephrin-A1 and osteopontin in non-small cell lung cancer 

      Rud, Ane Kristine Kongsgaard; Lund-Iversen, Marius; Berge, Gisle; Brustugun, Odd Terje; Solberg, Steinar; Mælandsmo, Gunhild; Pedersen, Kjetil Boye (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The metastasis-promoting protein S100A4 induces expression of ephrin-A1 and osteopontin in osteosarcoma cell lines. The aim of this study was to investigate S100A4-mediated stimulation of ephrin-A1 and osteopontin in non-small cell lung cancer (NSCLC) cell lines, and to characterize the expression of these biomarkers in primary tumor tissue from NSCLC patients. Four NSCLC cell lines were treated ...

    • Cytoplasmic BRMS1 expression in malignant melanoma is associated with increased disease-free survival 

      Slipicevic, Ana; Holm, Ruth; Emilsen, Elisabeth; Rosnes, Anne Katrine Ree; Welch, Danny R.; Mælandsmo, Gunhild; Flørenes, Vivi Ann (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Breast cancer metastasis suppressor 1 (BRMS1) blocks metastasis in melanoma xenografts; however, its usefulness as a biomarker in human melanomas has not been widely studied. The goal was to measure BRMS1 expression in benign nevi, primary and metastatic melanomas and evaluate its impact on disease progression and prognosis. Paraffin-embedded tissue from 155 primary melanomas, 69 metastases and 15 ...

    • Natural Transformation Facilitates Transfer of Transposons, Integrons and Gene Cassettes between Bacterial Species 

      Domingues, Sara; Harms, Klaus; Fricke, W. Florian; Johnsen, Pål Jarle; da Silva, Gabriela J.; Nielsen, Kåre M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      We have investigated to what extent natural transformation acting on free DNA substrates can facilitate transfer of mobile elements including transposons, integrons and/or gene cassettes between bacterial species. Naturally transformable cells of Acinetobacter baylyi were exposed to DNA from integron-carrying strains of the genera Acinetobacter, Citrobacter, Enterobacter, Escherichia, Pseudomonas, ...

    • Controlling Antimicrobial Resistance through Targeted, Vaccine-Induced Replacement of Strains 

      Tekle, Yonas I.; Nielsen, Kaare Magne; Liu, Jingzhou; Pettigrew, Melinda M.; Meyers, Lauren A.; Galvani, Alison P.; Townsend, Jeffrey P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Vaccination has proven effective in controlling many infectious diseases. However, differential effectiveness with regard to pathogen genotype is a frequent reason for failures in vaccine development. Often, insufficient immune response is induced to prevent infection by the diversity of existing serotypes present in pathogenic populations of bacteria. These vaccines that target a too narrow spectrum ...

    • Potentials of Chitosan-based Delivery Systems in Wound Therapy: Bioadhesion Study 

      Hurler, Julia; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Chitosan is currently proposed to be one of the most promising polymers in wound dressing development. Our research focuses on its potential as a vehicle for nano-delivery systems destined for burn therapy. One of the most important features of wound dressing is its bioadhesion to the wounded site. We compared the bioadhesive properties of chitosan with those of Carbopol, a synthetic origin polymer. ...

    • Dacarbazine and the Agonistic TRAIL Receptor-2 Antibody Lexatumumab Induce Synergistic Anticancer Effects in Melanoma 

      Engesæter, Birgit Øvstebø; Engebråten, Olav; Flørenes, Vivi Ann; Mælandsmo, Gunhild (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Mapatumumab and lexatumumab (targeting death receptor 4 (DR4) and 5 (DR5), respectively) are agonistic TRAIL receptor antibodies that induce apoptosis in a wide range of cancer cells. The potency of mapatumumab and lexatumumab was assessed in mono therapy protocols, and the ability to sensitize for dacarbazine (DTIC) treatment was explored in ten different melanoma cell lines. Our data indicated ...

    • Characterization and Cytotoxicity Studies of the Rare 21:4 n-7 Acid and Other Polyunsaturated Fatty Acids from the Marine Opisthobranch Scaphander lignarius, Isolated Using Bioassay Guided Fractionation 

      Vasskog, Terje; Andersen, Jeanette hammer; Hansen, Espen; Svenson, Johan (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The marine opisthobranch Scaphander lignarius has been analyzed in the systematic search for novel bioactive compounds in Arctic marine organisms using bioassay guided fractionation. A number of highly cytotoxic fractions were shown to contain mainly polyunsaturated fatty acids (PUFAs). Selected PUFAs were isolated and identified using both liquid chromatography-mass spectrometry (LC-MS) and nuclear ...

    • Use of 3-D modelling in early development phase of pectin tablets 

      Salbu, Linda; Picker-Freyer, Katharina M.; Schmid, Wolfgang; Bauer-Brandl, Annette; Tho, Ingunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      This study examines the contribution of the 3-D model in an early development set-up for pectin tablets. Therefore, the aim of this work is to extract as much information on the compression behaviour from as few tablets as possible. Pectins with various degrees of methoxylation (DM) were studied (4-72%). The compressibility was evaluated by classical “in-die” Heckel and Kawakita analyses in addition ...

    • A Trade-off between the Fitness Cost of Functional Integrases and Long-term stability of Integrons 

      Starikova, Irina; Harms, Klaus; Haugen, Pål; Lunde, Tracy Munthali; Primicerio, Raul; Samuelsen, Ørjan; Nielsen, Kaare Magne; Johnsen, Pål Jarle (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Horizontal gene transfer (HGT) plays a major role in bacterial microevolution as evident from the rapid emergence and spread of antimicrobial drug resistance. Few studies have however addressed the population dynamics of newly imported genetic elements after HGT. Here, we show that newly acquired class-1 integrons from Salmonella enterica serovar Typhimurium and Acinetobacter baumannii, free of ...