English
norskBlar i tittel Artikler, rapporter og annet (farmasi)
Viser treff 221-240 av 358
-
Nanomedicines for the topical treatment of vulvovaginal infections: Addressing the challenges of antimicrobial resistance
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-30)Recent years have, surprisingly, witnessed an increase in incidence of sexually transmitted infections (STIs). At the same time, antimicrobial therapy came under the threat of ever rising antimicrobial resistance (AMR), resulting in STIs with extremely limited therapy options. In this review, we addressed the challenges of treating vaginal infections in an era of AMR. We focused on published work ... -
Nanopharmaceuticals for improved topical vaginal delivery: Can they deliver?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Nanopharmaceuticals have the potential to revolutionise medical treatment by permitting the design of more potent, less toxic “smart” therapeutics, ultimately leading to personalised medicine. This review summarises the challenges and potential uses of nanodelivery system for the topical drug therapy of vaginal diseases. The vaginal route of drug administration remains a challenge in the development ... -
Natural Transformation Facilitates Transfer of Transposons, Integrons and Gene Cassettes between Bacterial Species
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)We have investigated to what extent natural transformation acting on free DNA substrates can facilitate transfer of mobile elements including transposons, integrons and/or gene cassettes between bacterial species. Naturally transformable cells of Acinetobacter baylyi were exposed to DNA from integron-carrying strains of the genera Acinetobacter, Citrobacter, Enterobacter, Escherichia, Pseudomonas, ... -
A new preparation method for preparation of liposomes-in-hydrogels primed for treatment of skin diseases
(Conference object; Konferansebidrag, 2014)<p>Liposomes are spherical vesicles that form spontaneously when phospholipids are dispersed in an aqueous medium. However, to get liposomes with a more unimodal size distribution, liposomes are usually processed further to reduced size and lammellarity, typically by extrusion, sonication or homogenization. <p>Liposome formulations for topical application needs a vehicle to assure the desirable ... -
No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): A quasi-experimental before-after study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-01)<i>Background</i> - Low dose naltrexone (LDN) is reported to have beneficial effects in several autoimmune diseases. The purpose of this study was to examine whether starting LDN was followed by changes in the dispensing of thyroid hormones to patients with hypothyroidism.<p> <p><i>Methods</i> - We performed a quasi-experimental before-after study based on the Norwegian Prescription Database. ... -
No effect of natural transformation on the evolution of resistance to bacteriophages in the Acinetobacter baylyi model system.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016)The adaptive benefits of natural transformation, the active uptake of free DNA molecules from the environment followed by incorporation of this DNA into the genome, may be the improved response to selection resulting from increased genetic variation. Drawing analogies with sexual reproduction, transformation may be particularly beneficial when selection rapidly fluctuates during coevolution with ... -
The Norwegian Society for Pharmacoepidemiology
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-16)The Norwegian Society for Pharmacoepidemiology (NFFE) is a multidisciplinary, nation-wide network of professionals involved in the field of pharmacoepidemiology. Pharmacoepidemiology is the science that bridges epidemiologic methodology with clinical pharmacology and clinical pharmacy, for studying the use, effectiveness, value and safety of pharmaceuticals1 . The foundation of NFFE took into ... -
A Novel Approach for the Treatment of Aerobic Vaginitis: Azithromycin Liposomes-in-Chitosan Hydrogel
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-28)Biocompatible mucoadhesive formulations that enable a sustained drug delivery at the site of action, while exhibiting inherent antimicrobial activity, are of great importance for improved local therapy of vaginal infections. The aim of this research was to prepare and evaluate the potential of the several types of azithromycin (AZM)-liposomes (180–250 nm) incorporated into chitosan hydrogel (A ... -
Novel in situ gel-forming solid dosage form (gfSDF) prepared by the simple syringe-based moulding: A screening study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-05)The aim of this study was to prepare and optimize a novel type of in situ gel-forming solid dosage form (gfSDF) to be used in the treatment of mucosal/skin ulcerations. For this purpose, a simple but reliable syringe-based hot melt/moulding method was employed. Chloramphenicol (antibiotic) and ibuprofen (anti-inflammatory) were chosen as model active pharmaceutical ingredients (APIs) to be loaded ... -
Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-10)DYRK1A is one of five members of the dual-specificity tyrosine (Y) phosphorylation-regulated kinase (DYRK) family. The DYRK1A gene is located in the Down syndrome critical region and regulates cellular processes related to proliferation and differentiation of neuronal progenitor cells during early development. This has focused research on its role in neuronal degenerative diseases, including ... -
Nucleic acid peptide nanogels for the treatment of bacterial keratitis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-14)Cage-shaped nucleic acid nanocarriers are promising molecular scaffolds for the organization of polypeptides. However, there is an unmet need for facile loading strategies that truly emulate nature's host–guest systems to drive encapsulation of antimicrobial peptides (AMPs) without loss of biological activity. Herein, we develop DNA nanogels with rapid in situ loading of L12 peptide during the thermal ... -
Nucleic acids hybrids as advanced antibacterial nanocarriers
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-08)Conventional antibiotic therapy is often challenged by poor drug penetration/accumulation at infection sites and poses a significant burden to public health. Effective strategies to enhance the therapeutic efficacy of our existing arsenal include the use of nanoparticulate delivery platforms to improve drug targeting and minimize adverse effects. However, these nanocarriers are often challenged by ... -
Ny diagnostikk for Alzheimers i Nytt Senter
(Chronicle; Kronikk, 2015-04-23) -
Old drug, new wrapping – A possible comeback for chloramphenicol?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-12)The antimicrobial drug chloramphenicol (CAM) exhibits activity against resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). However, its use has been limited due to its toxicity. As the threat of antibiotic resistance continues to grow, a promising approach might be to increase the use of historical antimicrobial agents that demonstrate clinical efficacy, but are hampered ... -
On the Therapeutic Potential of ERK4 in Triple-Negative Breast Cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-21)ERK3 and ERK4 define a distinct and understudied subfamily of mitogen-activated protein kinases (MAPKs). Little is known about the physiological roles of these atypical MAPKs and their association with human diseases. Interestingly, accumulating evidence points towards a role for ERK3 and ERK4 signaling in the initiation and progression of various types of cancer. Notably, a recent study reported ... -
Oncolytic peptides DTT-205 and DTT-304 induce complete regression and protective immune response in experimental murine colorectal cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-24)Oncolytic peptides represent a novel, promising cancer treatment strategy with activity in a broad spectrum of cancer entities, including colorectal cancer (CRC). Cancer cells are killed by immunogenic cell death, causing long-lasting anticancer immune responses, a feature of particular interest in non-immunogenic CRC. Oncolytic peptides DTT-205 and DTT-304 were administered by intratumoral injection ... -
Osteopontin is a prognostic biomarker in non-small cell lung cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Background: In a previously published report we characterized the expression of the metastasis-associated proteins S100A4, osteopontin (OPN) and ephrin-A1 in a prospectively collected panel of non-small cell lung cancer (NSCLC) tumors. The aim of the present follow-up study was to investigate the prognostic impact of these potential biomarkers in the same patient cohort. In addition, circulating ... -
Patient perceptions and experiences with medication-related activities in the emergency department: a qualitative study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-22)Background - Emergency department (ED) pharmacists reduce medication errors and improve quality of medication use. Patient perceptions and experiences with ED pharmacists have not been studied. The aim of this study was to explore patients’ perceptions of and experiences with medication-related activities in the ED, with and without an ED pharmacist present.<p> <p>Methods - We conducted 24 ... -
Pax6 regulates the expression of Dkk3 in murine and human cell lines, and altered responses to Wnt signaling are shown in Flpln-3T3 cells stably expressing either the Pax6 or the Pax6(5a) Isoform
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Pectosomes and Chitosomes as Delivery Systems for Metronidazole: The One-Pot Preparation Method
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Mucoadhesive liposomes offer a potential for improved residence time of liposomal systems targeting contact with mucosal tissues, such as in buccal, oral, colon, and vaginal drug delivery. Most of the currently available methods rely on the coating of preformed liposomes by various mucoadhesive polymers. The aim of this study was to develop novel mucoadhesive system by the one-pot preparation method. ...
