Blar i tittel Artikler, rapporter og annet (farmasi)

Viser treff 330-349 av 358

    • Tailored anti-biofilm activity – Liposomal delivery for mimic of small antimicrobial peptide 

      Hemmingsen, Lisa Myrseth; Giordani, Barbara; Paulsen, Marianne Hagensen; Vanic, Zeljka; Flaten, Gøril Eide; Vitali, Beatrice; Basnet, Purusotam; Bayer, Annette; Strøm, Morten B.; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-13)
      The eradication of bacteria embedded in biofilms is among the most challenging obstacles in the management of chronic wounds. These biofilms are found in most chronic wounds; moreover, the biofilm-embedded bacteria are considerably less susceptible to conventional antimicrobial treatment than the planktonic bacteria. Antimicrobial peptides and their mimics are considered attractive candidates in the ...

    • Targeted PFAS analyses and Extractable Organofluorine – Enhancing our Understanding of the presence of unknown PFAS in Norwegian wildlife 

      Herzke, Dorte; Nikiforov, Vladimir; Yeung, Leo WY.; Moe, Børge; Routti, Heli Anna Irmeli; Nygård, Torgeir; Gabrielsen, Geir W.; Hanssen, Linda (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-17)
      With the current possible presence of thousands of PFAS compounds in industrial emissions, there is an increasing need to assess the impacts of PFAS regulation of conventional PFAS on one hand and the exposure to emerging and yet unknown PFAS on the other. Today’s analytical methodologies using targeted approaches are not sufficient to determine the complete suite of PFAS present. To evaluate the ...

    • Testing for the fitness benefits of natural transformation during community-embedded evolution 

      Winter, Macaulay; Harms, Klaus; Johnsen, Pål Jarle; Buckling, Angus; Vos, Michiel (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-01)
      Natural transformation is a process where bacteria actively take up DNA from the environment and recombine it into their genome or reconvert it into extra-chromosomal genetic elements. The evolutionary benefits of transformation are still under debate. One main explanation is that foreign allele and gene uptake facilitates natural selection by increasing genetic variation, analogous to meiotic ...

    • The Antimicrobial Properties of Chitosan Can be  Tailored by Formulation 

      Jøraholmen, May Wenche; Bhargava, Abhilasha; Julin, Kjersti; Johannessen, Mona; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-31)
      Topical administration of drugs into the vagina can provide local therapy of vaginal infections, preventing the possible systemic side effects of the drugs. The natural polysaccharide chitosan is known for its excellent mucoadhesive properties, safety profile, and antibacterial effects, and thus it can be utilized in improving localized vaginal therapy by prolonging the residence time of a drug at ...

    • Time distribution for pharmacists conducting a randomized controlled trial — An observational time and motion study. 

      Havnes, Kjerstin; Lehnbom, Elin; Walter, Scott R.; Garcia, Beate; Halvorsen, Kjell H. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-30)
      Introduction - An expected future increase in older adults will demand changes in health care delivery, making development, implementation and evaluation of new health care models essential. The rationale for political decision-making concerning the implementation and application of interventions in health care should include cost estimations, specifically those involving clinical interventions. To ...

    • Timing is everything: Survival of Atlantic salmon Salmo salar postsmolts during events of high salmon lice densities 

      Bøhn, Thomas; Gjelland, Karl Øystein; Serra Llinares, Rosa Maria; Finstad, Bengt; Primicerio, Raul; Nilsen, Rune; Karlsen, Ørjan; Sandvik, Anne Dagrun; Skilbrei, Ove Tommy; Elvik, Kristine Marit Schrøder; Skaala, Øystein; Bjørn, Pål Arne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-07)
      <ol> <li>Atlantic salmon in aquaculture act as reservoir hosts and vectors of parasites like salmon lice and this parasite is shown to harm wild salmonid populations.</li> <li>In this study, <i>n</i> = 29,817 tagged Atlantic salmon were studied in four release trials. Half of the released fish were given prophylactic treatment against lice, the other half represented sham control fish. We used ...

    • Tn1 transposition in the course of natural transformation enables horizontal antibiotic resistance spread in Acinetobacter baylyi 

      Kloos, Julia Maria; Johnsen, Pål Jarle; Harms, Klaus (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-03)
      Transposons are genetic elements that change their intracellular genomic position by transposition and are spread horizontally between bacteria when located on plasmids. It was recently discovered that transposition from fully heterologous DNA also occurs in the course of natural transformation. Here, we characterize the molecular details and constraints of this process using the replicative transposon ...

    • Tn1546 is part of a larger plasmid-encoded genetic unit horizontally disseminated among clonal Enterococcus faecium lineages 

      Sletvold, H; Johnsen, PJ; Wikmark, Odd-Gunnar; Simonsen, Gunnar Skov; Sundsfjord, A; Nielsen, KM (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
      o determine the genetic composition of the first VanA-type plasmid (pIP816) reported, which was isolated from a clinical Enterococcus faecium (BM4147) strain in France in 1986, and to reveal the genetic units responsible for the dissemination of the vanA gene cluster by comparisons with current, published and additionally generated vanA-spanning plasmid sequences obtained from a heterogeneous E. ...

    • Toxicity Assessment of Resveratrol Liposomes-in-Hydrogel Delivery System by EpiVaginal Tissue Model 

      Jøraholmen, May Wenche; Damdimopoulou, Pauliina; Acharya, Ganesh; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-17)
      The natural polyphenol resveratrol (RES) has shown great potential as an antimicrobial, including against microbes associated with vaginal infections. To fully exploit the activities of RES, an all-natural ingredients formulation for RES delivery at vaginal site has been developed, namely liposomes loaded with RES, incorporated into a chitosan hydrogel as secondary vehicle. Although considered ...

    • A Trade-off between the Fitness Cost of Functional Integrases and Long-term stability of Integrons 

      Starikova, Irina; Harms, Klaus; Haugen, Pål; Lunde, Tracy Munthali; Primicerio, Raul; Samuelsen, Ørjan; Nielsen, Kaare Magne; Johnsen, Pål Jarle (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Horizontal gene transfer (HGT) plays a major role in bacterial microevolution as evident from the rapid emergence and spread of antimicrobial drug resistance. Few studies have however addressed the population dynamics of newly imported genetic elements after HGT. Here, we show that newly acquired class-1 integrons from Salmonella enterica serovar Typhimurium and Acinetobacter baumannii, free of ...

    • Transcription factor PAX6 as a novel prognostic factor and putative tumour suppressor in non-small cell lung cancer 

      Kiselev, Yury; Andersen, Sigve; Johannessen, Charles; Fjukstad, Bjørn; Olsen, Karina Standahl; Stenvold, Helge; Al-Saad, Samer; Dønnem, Tom; Richardsen, Elin; Bremnes, Roy M.; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-22)
      Lung cancer is the leading cause of cancer deaths. Novel predictive biomarkers are needed to improve treatment selection and more accurate prognostication. PAX6 is a transcription factor with a proposed tumour suppressor function. Immunohistochemical staining was performed on tissue microarrays from 335 non-small cell lung cancer (NSCLC) patients for PAX6. Multivariate analyses of clinico-pathological ...

    • Transposon-insertion sequencing screens unveil requirements for EHEC growth and intestinal colonization 

      Warr, Alyson R; Hubbard, Troy P; Munera, Diana; Blondel, Carlos J; Abel zur Wiesch, Pia; Abel, Sören; Wang, Xiaoxue; Davis, Brigid M.; Waldor, Matthew K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-12)
      Enterohemorrhagic <i>Escherichia coli</i> O157:H7 (EHEC) is an important food-borne pathogen that colonizes the colon. Transposon-insertion sequencing (TIS) was used to identify genes required for EHEC and <i>E. coli</i> K-12 growth <i>in vitro</i> and for EHEC growth <i>in vivo</i> in the infant rabbit colon. Surprisingly, many conserved loci contribute to EHEC’s but not to K-12’s growth <i>in ...

    • A Trial-Based Cost-Utility Analysis of a Medication Optimization Intervention Versus Standard Care in Older Adults 

      Robinson, Eirin Guldsten; Gyllensten, Hanna; Johansen, Jeanette Schultz; Havnes, Kjerstin; Granås, Anne Gerd; Bergmo, Trine Strand; Småbrekke, Lars; Garcia, Beate Hennie; Halvorsen, Kjell Hermann (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-22)
      Background - Older adults are at greater risk of medication-related harm than younger adults. The Integrated Medication Management model is an interdisciplinary method aiming to optimize medication therapy and improve patient outcomes.<p> <p>Objective - We aimed to investigate the cost effectiveness of a medication optimization intervention compared to standard care in acutely hospitalized older ...

    • Ulcerative colitis: Functional analysis of the in-depth proteome 

      Schniers, Armin; Goll, Rasmus; Pasing, Yvonne; Sørbye, Sveinung; Florholmen, Jon; Hansen, Terkel (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-29)
      <p><i>Background - </i>Ulcerative colitis (UC) is one major form of inflammatory bowel disease. The cause and the pathophysiology of the disease are not fully understood and we therefor aim in this study to identify important pathophysiological features in UC from proteomics data. <p><i>Methods - </i>Colon mucosa biopsies from inflamed tissue of untreated UC patients at diagnosis and from healthy ...

    • Ultrasound-mediated destabilization and drug release from liposomes comprising dioleoylphosphatidylethanolamine 

      Evjen, Tove Julie; Nilssen, Esben A.; Barnert, Sabine; Schubert, Rolf; Brandl, Martin; Fossheim, Sigrid L (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Novel sonosensitive doxorubicin-containing liposomes comprising dioleoylphosphatidylethanolamine (DOPE) as the main lipid constituent were developed and characterized in terms of ultrasound-mediated drug release in vitro. The liposome formulation showed high sonosensitivity; where approximately 95% doxorubicin was released from liposomes after 6 min of 40 kHz US exposure in buffered sucrose solution. ...

    • Understanding the binding of inhibitors of matrix metalloproteinases by molecular docking, quantum mechanical calculations, molecular dynamics simulations, and a MMGBSA/MMBappl study 

      Singh, Tanya; Adekoya, Olayiwola; Jayaram, B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-14)
      Matrix metalloproteinases (MMPs) consist of a class of proteins required for normal tissue function. Their over expression is associated with many disease states and hence the interest in MMPs as drug targets. Almost all MMP inhibitors have been reported to fail in clinical trials due to lack of specificity. Zinc in the binding site of metalloproteinases performs essential biological functions ...

    • Uptake and organ distribution of feed introduced plasmid DNA in growing or pregnant rats 

      Grønsberg, Idun; Nordgård, Lise; Fenton, Kristin Andreassen; Hegge, Beate; Nielsen, Kaare Magne; Bardocz, Susan; Pusztai, Arpad; Traavik, Ingemar Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)

    • Use of 3-D modelling in early development phase of pectin tablets 

      Salbu, Linda; Picker-Freyer, Katharina M.; Schmid, Wolfgang; Bauer-Brandl, Annette; Tho, Ingunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      This study examines the contribution of the 3-D model in an early development set-up for pectin tablets. Therefore, the aim of this work is to extract as much information on the compression behaviour from as few tablets as possible. Pectins with various degrees of methoxylation (DM) were studied (4-72%). The compressibility was evaluated by classical “in-die” Heckel and Kawakita analyses in addition ...

    • Use of a Commercially Available Microarray to Characterize Antibiotic-Resistant Clinical Isolates of Klebsiella pneumoniae 

      Charnock, Colin; Samuelsen, Ørjan; Nordlie, Anne-Lise; Hjeltnes, Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-22)
      Commercially available microarray (IDENTIBAC AMR-ve) for the detection of antibiotic resistance determinants was investigated for its potential to genotype 30 clinical isolates and two control strains of Klebsiella pneumoniae. Resistance profiles and the production of extended-spectrum b-lactamases were determined by disc diffusion and the results were compared with the microarray profiles in order ...

    • Use of Selective Serotonin Reuptake Inhibitors – Validity of Self-Report versus Plasma Concentrations and Pharmacy Dispensations – A Cross-Sectional Analysis of the Norwegian Women and Cancer Study 

      Waaseth, Marit; Havelkova, Martina; Forsdahl, Guro; Lund, Eiliv; Log, Tomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-30)
      Purpose: To validate self-reported current use of selective serotonin reuptake inhibitors (SSRI) in the Norwegian Women and Cancer study (NOWAC) and to identify factors associated with discordance between data sources.<p> <p>Material and Methods: This is a cross-sectional record-linkage study comparing SSRI-use derived from four data sources: 1) Specific SSRI questions in the main NOWAC questionnaire, ...