• Identifying the drivers of multidrug-resistant Klebsiella pneumoniae at a European level 

      Kachalov, Viacheslav N.; Nguyen, Huyen; Balakrishna, Suraj; Salazar-Vizcaya, Luisa; Sommerstein, Rami; Kuster, Stefan P.; Hauser, Anthony; Abel-Zur Wiesch Genannt Hülsho, Pia Karoline; Klein, E; Kouyos, Roger D. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-29)
      Beta-lactam- and in particular carbapenem-resistant Enterobacteriaceae represent a major public health threat. Despite strong variation of resistance across geographical settings, there is limited understanding of the underlying drivers. To assess these drivers, we developed a transmission model of cephalosporin- and carbapenem-resistant <i>Klebsiella pneumoniae</i>. The model is parameterized using ...
    • RESTAMP – Rate estimates by sequence-tag analysis of microbial populations 

      Mahmutovic, Anel; Gillman, Aaron Nicholas; Lauksund, Silje; Robson Moe, Natasha-Anne; Manzi, Aimé; Storflor, Merete; Abel-Zur Wiesch Genannt Hülsho, Pia Karoline; Abel, Sören (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-19)
      Microbial division rates determine the speed of mutation accumulation and thus the emergence of antimicrobial resistance. Microbial death rates are affected by antibiotic action and the immune system. Therefore, measuring these rates has advanced our understanding of host-pathogen interactions and antibiotic action. Several methods based on marker-loss or few inheritable neutral markers exist that ...