Viser treff 273-292 av 525

    • Label-free measurement of antimicrobial peptide interactions with lipid vesicles and nanodiscs using microscale thermophoresis 

      Rainsford, Philip; Rylandsholm, Fredrik G.; Jakubec, Martin; Silk, Mitchell; Juskewitz, Eric; Ericson, Johanna U; Svendsen, John Sigurd Mjøen; Engh, Richard Alan; Isaksson, Johan Mattias (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-03)
      One strategy to combat antimicrobial resistance is the discovery of new classes of antibiotics. Most antibiotics will at some point interact with the bacterial membrane to either interfere with its integrity or to cross it. Reliable and efficient tools for determining the dissociation constant for membrane binding (K<sub>D</sub>) and the partitioning coefficient between the aqueous- and membrane ...
    • Label-free measurement of antimicrobial peptide interactions with lipid vesicles and nanodiscs using microscale thermophoresis 

      Rainsford, Philip Ben; Rylandsholm, Fredrik G.; Jakubec, Martin; Silk, Mitchell; Juskewitz, Eric; Ericson, Johanna Ulrica; Svendsen, John Sigurd Mjøen; Engh, Richard Alan; Isaksson, Johan Mattias (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-03)
      One strategy to combat antimicrobial resistance is the discovery of new classes of antibiotics. Most antibiotics will at some point interact with the bacterial membrane to either interfere with its integrity or to cross it. Reliable and efficient tools for determining the dissociation constant for membrane binding (K<sub><i>D</sub></i>) and the partitioning coefficient between the aqueous- and ...
    • Lactoferricin-inspired peptide AMC-109 augments the effect of ciprofloxacin against Pseudomonas aeruginosa biofilm in chronic murine wounds 

      Laulund, Anne Sofie; Schwartz, Franziska Angelika; Christophersen, Lars; Høiby, Niels; Svendsen, John Sigurd Mjøen; Stensen, Wenche Gunvor Berg; Thomsen, Kim; Cavanagh, Jorunn Pauline; Moser, Claus (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-23)
      Objectives: Chronic wounds are characterised by prolonged inflammation, low mitogenic activity, high protease/low inhibitor activity, microbiota changes and biofilm formation, combined with the aetiology of the original insult. One strategy to promote healing is to terminate the parasitism-like relationship between the biofilm-growing pathogen and host response. Antimicrobial peptide AMC-109 is a ...
    • Land-allocation and clan-formation in modern residential developments in Oman 

      Heim, Bernhard; Joosten, Marc; Richthofen, Aurel V; Rupp, Florian (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-20)
      Abstract Afordable housing with fair and transparent land-allocation measures is a challenge for many countries. The Sultanate of Oman solves this issue by means of land-allocation lotteries in which male and female citizens can participate in order to win a parcel of a new housing area. Besides supporting those in fnancial need the lottery aims to mix the separate tribes of Oman and thus contribute ...
    • Lateral membrane organization as target of an antimicrobial peptidomimetic compound 

      Melcrová, Adéla; Maity, Sourav; Melcr, Josef; de Kok, Niels A. W.; Gabler, Mariella; van der Eyden, Jonne; Stensen, Wenche Gunvor Berg; Svendsen, John Sigurd Mjøen; Driessen, Arnold J. M.; Marrink, Siewert J.; Roos, Wouter H. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-07)
      Antimicrobial resistance is one of the leading concerns in medical care. Here we study the mechanism of action of an antimicrobial cationic tripeptide, AMC-109, by combining high speed-atomic force microscopy, molecular dynamics, fluorescence assays, and lipidomic analysis. We show that AMC-109 activity on negatively charged membranes derived from Staphylococcus aureus consists of two crucial steps. ...
    • Ligand and solvent effects on CO2 insertion into group 10 metal alkyl bonds 

      Deziel, Anthony P.; Espinosa, Matthew; Pavlovic, Ljiljana; Charboneau, David J.; Hazari, Nilay; Hopmann, Kathrin Helen; Mercado, Brandon Q. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-09)
      The insertion of carbon dioxide into metal element σ-bonds is an important elementary step in many catalytic reactions for carbon dioxide valorization. Here, the insertion of carbon dioxide into a family of group 10 alkyl complexes of the type (<sup>R</sup>PBP)M(CH<sub>3</sub>) (<sup>R</sup>PBP = B(NCH<sub>2</sub>PR<sub>2</sub>)<sub>2</sub>C<sub>6</sub>H<sub>4</sub><sup>−</sup>; R = Cy or <sup>t</sup>Bu; ...
    • Ligand noninnocence in FeNO corroles: insights from β-octabromocorrole complexes 

      Norheim, Hans-Kristian; Capar, Jan; Einrem, Rune; Gagnon, Kevin J.; Beavers, Christine; Vazquez-Lima, Hugo; Ghosh, Abhik (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11-30)
      The first FeNO octabromocorroles have been synthesized including four β-octabromo-meso-tris(p-X-phenyl)corrole derivatives Fe[Br8TpXPC](NO) (X = CF3, H, CH3, OCH3) and the β-octabromo-meso-tris(pentafluorophenyl)corrole complex, Fe[Br8TPFPC](NO). The last complex, which proved amenable to single-crystal X-ray structure determination, exhibits the geometry parameters: Fe–N(O) 1.643(8) Å, N–O 1.158(9) ...
    • Ligand-Centered Triplet Diradical Supported by a Binuclear Palladium(II) Dipyrrindione 

      Ghosh, Abhik (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-04)
      Oligopyrroles form a versatile class of redox-active ligands and electron reservoirs. Although the stabilization of radicals within oligopyrrolic π systems is more common for macrocyclic ligands, bidentate dipyrrindiones are emerging as compact platforms for one-electron redox chemistry in transition-metal complexes. We report the synthesis of a bis(aqua) palladium(II) dipyrrindione complex and its ...
    • Lignocellulose Conversion via Catalytic Transformations Yields Methoxyterephthalic Acid Directly from Sawdust 

      Pedersen, Simon S.; Batista, Gabriel M. F.; Henriksen, Martin L.; Hammershøj, Hans Christian D.; Hopmann, Kathrin Helen; Skrydstrup, Troels (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-10)
      Poly(ethylene terephthalate) polyester represents the most common class of thermoplastic polymers widely used in the textile, bottling, and packaging industries. Terephthalic acid and ethylene glycol, both of petrochemical origin, are polymerized to yield the polyester. However, an earlier report suggests that polymerization of methoxyterephthalic acid with ethylene glycol provides a methoxy-polyester ...
    • Linear scaling Coulomb interaction in the multiwavelet basis, a parallel implementation 

      Jensen, Stig Rune; Juselius, Jonas; Durdek, Antoine Pacifique Romain; Flå, Tor; Wind, Peter; Frediani, Luca (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-08-27)
      We present a parallel and linear scaling implementation of the calculation of the electrostatic potential arising from an arbitrary charge distribution. Our approach is making use of the multi-resolution basis of multiwavelets. The potential is obtained as the direct solution of the Poisson equation in its Green’s function integral form. In the multiwavelet basis, the formally non local ...
    • Linking the Character of the Metal-Ligand Bond to the Ligand NMR Shielding in Transition-Metal Complexes: NMR Contributions from Spin-Orbit Coupling 

      Novotný, Jan; Vícha, Jan; Bora, Pankaj L.; Repisky, Michal; Straka, Michal; Komorovsky, Stanislav; Marek, Radek (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-06)
      Relativistic effects significantly affect various spectroscopic properties of compounds containing heavy elements. Particularly in Nuclear Magnetic Resonance (NMR) spectroscopy, the heavy atoms strongly influence the NMR shielding constants of neighboring light atoms. In this account we analyze paramagnetic contributions to NMR shielding constants and their modulation by relativistic spin–orbit ...
    • Lipids as Versatile Solvents for Chemical Synthesis 

      Gevorgyan, Ashot; Hopmann, Kathrin Helen; Bayer, Annette (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-23)
      Development of safe, renewable, cheap and versatile solvents is a longstanding challenge in chemistry. We show here that vegetable oils and related systems can become prominent solvents for organic synthesis. Suzuki–Miyaura, Hiyama, Stille, Sonogashira and Heck cross-couplings proceed with quantitative yields in a range of vegetable oils, fish oil, butter and waxes used as solvents. Appropriate ...
    • Lipopolysaccharide O-Antigen Prevents Phagocytosis of Vibrio anguillarum by Rainbow Trout (Oncorhynchus mykiss) Skin Epithelial Cells 

      Lindell, Kristoffer; Fahlgren, Anna; Hjerde, Erik; Willassen, Nils Peder; Fällman, Maria; Milton, Debra L (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Colonization of host tissues is a first step taken by many pathogens during the initial stages of infection. Despite the impact of bacterial disease on wild and farmed fish, only a few direct studies have characterized bacterial factors required for colonization of fish tissues. In this study, using live-cell and confocal microscopy, rainbow trout skin epithelial cells, the main structural component ...
    • Liposome Formulations for the Strategic Delivery of PARP1 Inhibitors: Development and Optimization 

      Conceição, Carlota J. F.; Moe, Elin; Ribeiro, Paulo A.; Raposo, Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-11)
      first_pagesettingsOrder Article Reprints Open AccessArticle Liposome Formulations for the Strategic Delivery of PARP1 Inhibitors: Development and Optimization by Carlota J. F. Conceição 1,2ORCID,Elin Moe 3,4,Paulo A. Ribeiro 2ORCID andMaria Raposo 2,*ORCID 1 CEFITEC, Department of Physics, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal 2 Laboratory ...
    • Local Oxidation States in {FeNO}<sup>6-8</sup> Porphyrins: Insights from DMRG/CASSCF-CASPT2 Calculations 

      Phung, Quan Manh; Nam, Ho Ngoc; Ghosh, Abhik (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-27)
      A first DMRG/CASSCF–CASPT2 study of a series of paradigmatic {FeNO}<sup>6</sup>, {FeNO}<sup>7</sup>, and {FeNO}<sup>8</sup> heme–nitrosyl complexes has led to substantial new insight as well as uncovered key shortcomings of the DFT approach. By virtue of its balanced treatment of static and dynamic correlation, the calculations have provided some of the most authoritative information available to ...
    • MabCent: Arctic marine bioprospecting in Norway 

      Svenson, Johan (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      The deep waters surrounding the coastline of the northern parts of Norway represent an exciting biotope for marine exploration. Dark and cold Arctic water generates a hostile environment where the ability to adapt is crucial to survival. These waters are nonetheless bountiful and a diverse plethora of marine organisms thrive in these extreme conditions, many with the help of specialised ...
    • Magnetic Diversity in Heteroisocorroles: Aromatic Pathways in 10-Heteroatom-Substituted Isocorroles 

      Foroutan-Nejad, Cina; Ghosh, Abhik (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-21)
      A recent study on magnetically induced currents in 10-isocorrole derivatives indicated that both the free-base and metal-complexed forms of the unsubstituted macrocycle are homoaromatic. Furthermore, depending on the substituents at the 10-position, the aromatic character was found to swing between substantially homoaromatic to substantially antihomoaromatic. Heteroisocorroles, in which the saturated ...
    • Magnetic properties with multiwavelets and DFT: The complete basis set limit achieved 

      Jensen, Stig Rune; Flå, Tor; Jonsson, Dan Johan; Monstad, Rune Sørland; Ruud, Kenneth; Frediani, Luca (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-11)
      Multiwavelets are emerging as an attractive alternative to traditional basis sets such as Gaussian-type orbitals and plane waves. One of their distinctive properties is the ability to reach the basis set limit (often a chimera for traditional approaches) reliably and consistently by fixing the desired precision ε. We present our multiwavelet implementation of the linear response formalism, applied ...
    • Main-Group-Element Isophlorin Complexes Revisited: The Question of a Subvalent Central Atom 

      Conradie, Jeanet; Brothers, Penelope Jane; Ghosh, Abhik (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-15)
      A careful density functional theory reexamination of the geometric and electronic structures of reduced main-group porphyrin complexes E(Por)L2 (E = Si or Ge; L = pyridine or tetrahydrofuran), B2(Por), and C2(Por) has confirmed these as pure isophlorin derivatives with normal-valent coordinated central atoms. Only axially unligated Ge(Por) and the dications [B2(Por)]2+ and [C2(Por)]2+ feature aromatic ...
    • The MAR databases: development and implementation of databases specific for marine metagenomics 

      Klemetsen, Terje; Raknes, Inge A.; Fu, Juan; Agafonov, Alexander; Balasundaram, Sudhagar V.; Tartari, Giacomo; Robertsen, Espen; Willassen, Nils Peder (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-02)
      We introduce the marine databases; <i>MarRef, MarDB</i> and <i>MarCat</i> (https://mmp.sfb.uit.no/databases/), which are publicly available resources that promote marine research and innovation. These data resources, which have been implemented in the Marine Metagenomics Portal (MMP) (https://mmp.sfb.uit.no/), are collections of richly annotated and manually curated contextual (metadata) and sequence ...