Blar i forfatter Artikler, rapporter og annet (kjemi) "Chirik, Paul J."

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    • Cobalt-Catalysed Alkene Hydrogenation: A Metallacycle Can Explain the Hydroxyl Activating Effect and the Diastereoselectivity 

      Morello, Glenn Robert; Zhong, Hongyu; Chirik, Paul J.; Hopmann, Kathrin Helen (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-04)
      Bis(phosphine)cobalt dialkyl complexes have been reported to be highly active in the hydrogenation of tri-substituted alkenes bearing hydroxyl substituents. Alkene substrates containing ether, ester, or ketone substituents show minimal reactivity, indicating an activating effect of the hydroxyl group. The mechanistic details of bis(phosphine)cobalt-catalysed hydrogenation were recently evaluated ...

    • Cobalt-Catalyzed Asymmetric Hydrogenation of Enamides: Insights into Mechanisms and Solvent Effects 

      Pavlovic, Ljiljana; Mendelsohn, Lauren N.; Zhong, Hongyu; Chirik, Paul J.; Hopmann, Kathrin Helen (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-25)
      The mechanistic details of the (<sup>Ph</sup>BPE)Co-catalyzed asymmetric hydrogenation of enamides are investigated using computational and experimental approaches. Four mechanistic possibilities are compared: a direct Co(0)/Co(II) redox path, a metathesis pathway, a nonredox Co(II) mechanism featuring an azametallacycle, and a possible enamide−imine tautomerization pathway. The results indicate ...

    • Mechanistic Investigations of the Asymmetric Hydrogenation of Enamides with Neutral Bis(phosphine) Cobalt Precatalysts 

      Mendelsohn, Lauren N.; Pavlovic, Ljiljana; Zhong, Hongyu; Friedfeld, Max R.; Shevlin, Michael; Hopmann, Kathrin Helen; Chirik, Paul J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-11)
      The mechanism of the asymmetric hydrogenation of prochiral enamides by well-defined, neutral bis(phosphine) cobalt(0) and cobalt(II) precatalysts has been explored using(R,R)-<sup>iPr</sup>DuPhos ((R,R)-<sup>iPr</sup>DuPhos = (+)-1,2-bis[(2R,5R)-2,5-diisopropylphospholano]benzene) as a representative chiral bis(phosphine) ligand. A series of (R,R)-(<sup>iPr</sup>DuPhos)Co(enamide) (enamide = ...