Blar i forfatter Artikler, rapporter og annet (kjemi) "Kahlke, Tim"

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    • The immediate global responses of Aliivibrio salmonicida to iron limitations 

      Thode, Sunniva Katharina; Kahlke, Tim; Robertsen, Espen Mikal; Hansen, Hilde; Haugen, Peik (Journal article; Tidsskriftartikkel, 2015-02-04)
      <i>Background</i>: Iron is an essential micronutrient for all living organisms, and virulence and sequestration of iron in pathogenic bacteria are believed to be correlated. As a defence mechanism, potential hosts therefore keep the level of free iron inside the body to a minimum. In general, iron metabolism is well studied for some bacteria (mostly human or animal pathogens). However, this area ...

    • Molecular Characterization of Cold Adaptation of Membrane Proteins in the Vibrionaceae Core-Genome 

      Kahlke, Tim; Thorvaldsen, Steinar (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Cold-adaptation strategies have been studied in multiple psychrophilic organisms, especially for psychrophilic enzymes. Decreased enzyme activity caused by low temperatures as well as a higher viscosity of the aqueous environment require certain adaptations to the metabolic machinery of the cell. In addition to this, low temperature has deleterious effects on the lipid bilayer of bacterial membranes ...

    • Unique core genomes of the bacterial family vibrionaceae: insights into niche adaptation and speciation 

      Kahlke, Tim; Goesmann, Alexander; Hjerde, Erik; Willassen, Nils Peder; Haugen, Peik (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The criteria for defining bacterial species and even the concept of bacterial species itself are under debate, and the discussion is apparently intensifying as more genome sequence data is becoming available. However, it is still unclear how the new advances in genomics should be used most efficiently to address this question. In this study we identify genes that are common to any group of genomes ...

    • Vibrionaceae core, shell and cloud genes are non-randomly distributed on Chr 1: An hypothesis that links the genomic location of genes with their intracellular placement 

      Sonnenberg, Cecilie Bækkedal; Kahlke, Tim; Haugen, Peik (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-06)
      <i>Background</i> - The genome of <i>Vibrionaceae</i> bacteria, which consists of two circular chromosomes, is replicated in a highly ordered fashion. In fast-growing bacteria, multifork replication results in higher gene copy numbers and increased expression of genes located close to the origin of replication of Chr 1 (<i>ori1</i>). This is believed to be a growth optimization strategy to satisfy ...