Blar i forfatter Artikler, rapporter og annet (kjemi) "Repo, Timo"

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    • Enantioselective incorporation of CO2: status and potential 

      Vaitla, Janakiram; Guttormsen, Yngve; Mannisto, Jere K.; Nova, Ainara; Repo, Timo; Bayer, Annette; Hopmann, Kathrin Helen (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-09)
      CO<sub>2</sub> is a promising and sustainable carbon feedstock for organic synthesis. New catalytic protocols for efficient incorporation of CO<sub>2</sub>into organic molecules are continuously being reported. However, little progress has been made in the enantioselective conversion of CO<sub>2</sub>to form enantioenriched molecules. In order to allow CO<sub>2</sub>to become a versatile carbon ...

    • Mechanistic Insights into Carbamate Formation from CO2 and Amines: The Role of Guanidine–CO2 Adducts, 

      Mannisto, Jere K.; Pavlovic, Ljiljana; Tiainen, Tony; Nieger, Martin; Sahari, Aleksi; Hopmann, Kathrin Helen; Repo, Timo (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-02)
      Capture of CO<sub>2</sub> by amines is an attractive synthetic strategy for the formation of carbamates. Such reactions can be mediated by superbases, such as 1,1,3,3-tetramethylguanidine (TMG), with previous implications that zwitterionic superbase–CO<sub>2</sub> adducts are able to actively transfer the carboxylate group to various substrates. Here we report a detailed investigation of zwitterionic ...

    • N-Heteroaryl Carbamates from Carbon Dioxide via Chemoselective Superbase−Catalysis: Substrate Scope and Mechanistic Investigation 

      Mannisto, Jere K.; Pavlovic, Ljiljana; Heikkinen, Johannes; Tiainen, Tony; Sahari, Aleksi; Maier, Norbert; Rissanen, Kari; Nieger, Martin; Hopmann, Kathrin Helen; Repo, Timo (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-16)
      We report a mild superbase-catalyzed and nitrogen-selective carboxylation of N-heteroaryls, with subsequent alkylation enabling the synthesis of drug-like O-alkyl carbamates in good yields (av. 86%). Our findings suggest a partial revision of the current mechanistic understanding as superbases upon mixing with indoles and azoles generally form uncharged hydrogen-bonded complexes and not ionic salts ...