Blar i forfatter Artikler, rapporter og annet (kjemi) "Timmins, Joanna"

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    • A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges 

      Timmins, Joanna; Moe, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-27)
      The Deinococcus radiodurans bacterium is extremely resistant to ionising radiation and desiccation and can withstand a 200-fold higher radiation dose than most other bacteria with no loss of viability. The mechanisms behind this extreme resistance are not fully understood, but it is clear that several factors contribute to this phenotype. Efficient scavenging of reactive oxygen species and repair ...

    • The three Endonuclease III variants of Deinococcus radiodurans possess distinct and complementary DNA repair activities 

      Sarre, Aili; Stelter, Meike; Rollo, Filipe; De Bonis, Salvatore; Seck, Anna; Hognon, Cecilia; Ravanat, Jean-Luc; Monari, Antonio; Dehez, Francois; Moe, Elin; Timmins, Joanna (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-28)
      Endonuclease III (EndoIII) is a bifunctional DNA glycosylase that removes oxidized pyrimidines from DNA. The genome of Deinococcus radiodurans encodes for an unusually high number of DNA glycosylases, including three EndoIII enzymes (drEndoIII1-3). Here, we compare the properties of these enzymes to those of their well-studied homologues from E. coli and human. Our biochemical and mutational data, ...