Blar i tittel Mastergradsoppgaver i farmasi

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    • Validering av selvrapportert legemiddelbruk hos deltakere med koronarsykdom i Tromsøundersøkelsen 

      Truong, Kieu Nhi Lise (Mastergradsoppgave; Master thesis, 2020-05-14)
      Bakgrunn: Hjerte- og karsykdommer er en fellesbetegnelse for sykdommer som involverer hjerte og blodårer. Det er en ledende årsak til død over hele verden. Flere epidemiologiske studier utføres for å undersøke årsakene til den økte sykdomsbelastningen. Ved å studere befolkningens mønster av legemiddelbruk og videre korrigere for feilbruk, kan vi redusere risikoen for nye hendelser og progresjon av ...

    • Validering og bruk av et verktøy for å vurdere kvalitet i sekundærprofylaktisk behandling ved hjerte- kar sykdom 

      Skare, Erik Eidem (Master thesis; Mastergradsoppgave, 2009-06)
      Bakgrunn: Masteroppgaven er en del av et doktorgradsprosjekt for utvikling av en klinisk farmasøytisk service for pasienter med etablert CHD. Legemiddelrelaterte problemer kan gi økte kostnader og redusert klinisk effekt av medisinsk behandling, og gode verktøy for vurdering av kvalitet i legemiddelbehandling er mangelvare. Forekomsten av CHD er økende i den vestlige verden, og en økende andel av ...

    • Virtual screening and in vitro evaluation of putative positive allosteric modulators of the GABAB receptor 

      Issifou, Ibrahim Toure (Mastergradsoppgave; Master thesis, 2020-05-14)
      -aminobutyric acid (GABA) is the chief inhibitory neurotransmitter of the central nervous system (CNS). GABA exhibits its function by binding to either the ionotropic GABAA receptor or the metabotropic GABAB receptor, causing a decrease in activity in the nervous system. Disruption in the GABAergic system has been associated with various neurological conditions, including Alzheimer’s disease, anxiety, ...

    • Zebrafish and safety pharmacology. Effects of ethanol on early brain and eye development. 

      Ali, Amina Mohammed (Master thesis; Mastergradsoppgave, 2014-05-21)
      Ethanol is well studied with regard to its teratogenic effects in different animal models including humans. Exposure of a fetus to alcohol during pregnancy can lead to fetal alcohol syndrome (FAS), or ethanol mediated toxicity in animal models. During early embryogenesis, development of the most important organs including the central nervous system (CNS) occurs. Disturbance of any function that ...

    • Zebrafish as a model system for safety pharmacology, using a glucocorticoid and an antimicrobial peptide as test substances 

      Albert, Ingrid (Master thesis; Mastergradsoppgave, 2013-05-20)
      The zebrafish is an exciting model organism with a lot to offer and many possible areas of application. Toxicity assays using zebrafish embryos are becoming increasingly popular with the pharmaceutical industry as a tool to bridge the gap between conventional cell based screens and animal testing. The main aim of this project was to explore the zebrafish as a model system for use in safety pharmacology, ...

    • Zwitterionic antimicrobial nanoparticles for biofilm therapy 

      Phung, Anna Ngoc (Mastergradsoppgave; Master thesis, 2021-05-10)
      In recent years, many pathogenic bacteria have developed resistance against the existing antimicrobials, a phenomenon known as antimicrobial resistance (AMR). One of the many reasons contributing to the observed failure of current therapies, is the poor drug penetration across the microbial biofilm. Biofilms are small structural communities of bacterial cells that excrete an extracellular polymeric ...

    • β-cyclodextrin polymers as cholesterol sequestrating agents 

      Fadeev, Nikolay Olegovich (Master thesis; Mastergradsoppgave, 2018-08-19)
      Summary Elevated serum cholesterol blood levels is one of the central risk factors for cardiovascular diseases. Lowering blood cholesterol have significant impact on lowering cardiovascular disease events. Inhibiting cholesterol absorption in small intestine can significantly lower serum cholesterol levels and thereby - lower cardiovascular events. Β-cyclodextrin (βCD)-dextran polymer is expected ...