Blar i forfatter Mastergradsoppgaver i farmasi "Hammer, Stine Gangnæs"

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    • Cloning and expression of wild-type and mutated forms of Bcr-Abl in a mouse pro-B cell line 

      Hammer, Stine Gangnæs (Master thesis; Mastergradsoppgave, 2006-06-12)
      Chronic myelogenous leukaemia is a monoclonal hematopoetic stem cell disorder characterised by the t(9;22) translocation and results in the constitutively activated Bcr-Abl tyrosine kinase. Since the tyrosine kinase activity of the Bcr-Abl fusion protein is the causative molecular event in CML, targeting the tyrosine kinase activity appears to be an attractive therapeutic strategy. Imatinib, ...