Blar i tittel Mastergradsoppgaver i biologi (Helsefak)

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    • Study of human PRKAR1A and its role in autophagy 

      Lamsal, Apsana (Master thesis; Mastergradsoppgave, 2018-05-11)
      The human PRKAR1A gene is a 381- amino acid protein encoding the regulatory subunit (RIα) of the cAMP dependent Protein Kinase A (PKA). The main function of PRKAR1A is to regulate the catalytic activity of PKA. PRKAR1A is shown to regulate autophagy via association with mTOR kinase and colocalization with the autophagy marker proteins LC3B, Rab7 and Rab9. Contradictory findings regarding the ...

    • Study of interaction between BK virus large T-antigen and agnoprotein 

      Adou, Koman Mireille Sophie Chinan (Master thesis; Mastergradsoppgave, 2011-08)
      Human polyomavirus BK (BKV) is a non enveloped virus with a double-stranded, circular DNA genome. BKV infects >70% of the human population world-wide. Infection occurs predominantly during childhood and the virus remains in a latent state throughout life in the immune competent individuals. In the context of immunosuppression, however, reactivation occurs and can lead to renal stenosis and interstitial ...

    • A study of possible genetic causes of inherited breast and ovarian cancer in a Norwegian cancer population 

      Jarhelle, Elisabeth (Master thesis; Mastergradsoppgave, 2013-05-15)
      Homologous recombination repair (HRR) is an important repair mechanism, and mutations disrupting the function of this machinery might contribute to cancer formation. Several proteins interact in this mechanism, and the two best known are BRCA1 and BRCA2. Mutations in their corresponding genes BRCA1 and BRCA2 are found in 40% of hereditary breast and ovarian cancer cases. However, there are still ...

    • A study of the interaction between MAPKAP Kinase 5 / MK5 and DNAJB1 

      Lægreid, Kari Jenssen (Master thesis; Mastergradsoppgave, 2011-05-02)
      The mitogen activated protein kinases (MAPK) are a large and diverse family of protein kinases, contributing to the cells ability to respond to external stimuli by relaying messages in a well orchestrated way until they reach their final destinations. This is achieved through successive phosphorylation events. One member of this large family is mitogen activated protein kinase activated protein ...

    • A study of the protein kinase MK5's effect on melanoma cell proliferation 

      Dumitriu, Gianina Aurica (Master thesis; Mastergradsoppgave, 2012-09-14)
      The mitogen-activated protein kinases (MAPKs) play a crucial role in cellular processes such as proliferation, differentiation, apoptosis, metabolism and motility. Both conventional and atypical MAPKs can phosphorylate other proteins referred to as MAPK- activated protein kinases (MAPKAPK) such as MK5 or p38-regulated /activated protein kinase. Mutations in the MK5 gene have been detected in lung, ...

    • A study of TRIM32 self-ubiquitination 

      Khan, Waqas (Master thesis; Mastergradsoppgave, 2020-05-15)
      TRIMs (tripartite motif proteins) constitute a family of ubiquitin E3 ligases that are involved in a variety of cellular processes including autophagy and carcinogenesis. TRIM32 contains an N-terminal RING finger domain, B-box region, a coiled-coil domain and six NHL repeats in the C-terminal region, which are involved in protein dimerization and substrate recognitions. Various mutations in the NHL ...

    • A study on the interactions between perfluorosulfonic acids and P-glycoprotein 

      Voloshyna, Tetyana (Mastergradsoppgave; Master thesis, 2021-05-18)
      Perfluoroalkyl substances (PFAS) have received a great deal of attention due to the ubiquitous occurrence and persistence in the environment, resistance to degradation, and biological accumulation in wildlife and humans. PFAS are being detected around the globe, raising concerns regarding the toxicity and health risks to humans. Studies have shown that environmental toxicants, including PFAS, can ...

    • Theoretical and experimental studies of thermolysin inhibition 

      Wuxiuer, Yimingjiang (Master thesis; Mastergradsoppgave, 2008-05-15)
      Zinc-metalloproteinases play a key role in the biosythesis and metabolism of different bioactive peptides. As a member of zinc-metalloproteinases, thermolysin has served as a model system to study the inhibition mechanism of other metalloproteinases. Inhibitors of thermolysin have considerable potential as therapeutic agents. In the present master thesis, docking calculations were performed and ...

    • The use of traditional and unconventional culturing methods for the discovery of antimicrobial compounds derived from marine microorganisms 

      Brocklesby, Charlotte Kit Mun (Mastergradsoppgave; Master thesis, 2023-05-15)
      The main aim is to evaluate the content of marine biofilms and different marine bacteria for antimicrobial potential. Hypothesis: antimicrobial compounds can be produced in the presence of other bacterial species; in the context of Winogradsky columns that simulate a naturalistic environment, and in the proximity to other species in the case of marine bacterial isolates. For this main aim and ...

    • The world of β-glucans : a review of biological roles, applications and potential areas of research 

      Ali, Syed Haris (Master thesis; Mastergradsoppgave, 2009-05-15)
      Among many known and tested immunomodulators, polysaccharides isolated from various natural sources occupy a prominent position. An important group of these polysaccharides is represented by the homopolymers of β-glucose, called β-glucans. Their very low-to-negligible toxicity and immunomodulating effects show the promise it has in the therapy of a variety of infectious and cancer illnesses. ...