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Downstream gene expression of wild type p53 tumor suppressor gene versus mutated and null p53
(Master thesis; Mastergradsoppgave, 2006-11)
P53 is a key tumor suppressor and transcription factor protecting us from cancer. The wild type p53 protein functions as a regulatory protein, triggering a variety of cellular responses to different signals. Activation of p53 can lead to cell division arrest, DNA repair, or apoptosis. More than 60% of all human cancers contain p53 mutations. P53 is also reported in many studies to play a role in the ...