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dc.contributor.authorBerg, Vivian
dc.contributor.authorCharles, Dolley
dc.contributor.authorBergdahl, Ingvar A.
dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorTornevi, Andreas
dc.contributor.authorHuber, Sandra
dc.contributor.authorFuskevåg, Ole Martin
dc.contributor.authorRylander, Charlotta
dc.date.accessioned2021-06-16T11:12:24Z
dc.date.available2021-06-16T11:12:24Z
dc.date.issued2021-02-09
dc.description.abstractObjective - Several risk factors for type 2 diabetes mellitus (T2DM) are also associated with blood concentrations of persistent organic pollutants (POPs), and factors related to the disease may affect POP concentrations, and subsequent associations between POPs and T2DM. The purpose of this pilot study was to investigate the change in concentrations of lipids, hormones and POPs pre- and post-diagnosis in T2DM cases compared to healthy controls and their associations with T2DM.<p> <p>Methods - We measured POPs, lipids, and thyroid and steroid hormones in plasma from 44 female cases collected prior to (pre-diagnostic) and following (post-diagnostic) T2DM diagnosis, and in 44 healthy female age-matched controls. We compared cross-sectional differences and longitudinal changes within and between matched cases and controls with t-tests and multivariable linear regression models. Associations between POP concentrations and T2DM were investigated using conditional logistic regression.<p> <p>Results - Between the pre- and post-diagnostic measurement, cases developed more favorable lipid profiles and the longitudinal changes in lipid-normalized concentrations of non-dioxin-like polychlorinated biphenyls (PCBs), dioxin-like PCBs, beta-hexachlorocyclohexane (HCH), HCB, and 1,1,1-trichloro-2,2-bis(4-chlorophenyl) ethane (p,p'-DDE) differed significantly between cases and controls. The longitudinal changes in POPs were mainly driven by changes in bodyweight, total lipids and T2DM status. Cases had significantly higher pre-diagnostic concentrations of POPs and triglycerides, and lower concentrations of high-density lipoprotein cholesterol and free thyroxin than controls. Pre-diagnostic POP concentrations were not significantly associated with incident T2DM, whereas several post-diagnostic POP concentrations were significantly positively associated with prevalent T2DM.<p> <p>Conclusions - This pilot study suggests that factors related to T2DM affect blood concentrations of POPs and may partly explain the positive associations between POPs and T2DM.en_US
dc.identifier.citationBerg, Charles, Bergdahl, Nøst, Sandanger, Tornevi, Huber, Fuskevåg, Rylander. Pre- and post-diagnostic blood profiles of chlorinated persistent organic pollutants and metabolic markers in type 2 diabetes mellitus cases and controls; a pilot study. Environmental Research. 2021;195:110846:1-7en_US
dc.identifier.cristinIDFRIDAID 1914823
dc.identifier.doi10.1016/j.envres.2021.110846
dc.identifier.issn0013-9351
dc.identifier.issn1096-0953
dc.identifier.urihttps://hdl.handle.net/10037/21455
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalEnvironmental Research
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titlePre- and post-diagnostic blood profiles of chlorinated persistent organic pollutants and metabolic markers in type 2 diabetes mellitus cases and controls; a pilot studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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