Now showing items 21-40 of 53

    • A new fluorous-tagged porphyrinoid 

      Larsen, Simon (Master thesis; Mastergradsoppgave, 2012-08-16)
      The field of corrole chemistry has flourished over the past decade. Simple and high-yielding procedures have made the corrole ligand readily available, and several procedures on how to functionalize and otherwise modify corroles and their metal complexes have been reported. During an attempt to synthesize corrole from a fluorous tagged aromatic aldehyde a new porphyrinoid has been isolated from ...
    • Karakterisering av kommersielle omega-3 produkter og utvikling av en ny metode for separasjon av lipidklasser med fast-fase ekstraksjon 

      Ovesen, Marte Stokvik (Master thesis; Mastergradsoppgave, 2012-11-15)
      Kliniske studier viser at inntak av omega-3 fettsyrene EPA, DPA og DHA kan bidra til å forebygge hjerte- og karsykdommer, redusere inflammasjon, påvirke sentralnervesystemets funksjon positivt og bidra til en rekke andre helsegevinster. Som en konsekvens har markedet for kommersielle omega-3 produkter økt de siste tiårene. Det ble kjøpt inn 10 produkter til dette studiet. Produktene baserte seg på ...
    • Synthesis of β-substituted β-aminoboronates 

      Thomassen, Ivar Kristian (Master thesis; Mastergradsoppgave, 2013-05)
      Recent work at the University of Tromsø has uncovered new α-substituted α- and β-aminoboron containing peptidomimetics that shows antimicrobial, antifungal and antitubercular activity in addition to kinase inhibition and promotion. As a continuation of this work a new approach for the synthesis of β-substituted β-aminoboronates has been developed. The approach involves the non-stereospecific ...
    • Biotech applications of protein kinase affinity interactions 

      Lund, Bjarte Aarmo (Master thesis; Mastergradsoppgave, 2013-05)
      Protein kinases provide one of the cell’s most important methods for signaling and control. 2% of the encoding genome consists of protein kinase genes, and from 10-50% of the proteins in the cell are phosphorylated at some point in the cell cycle. Malfunction of protein kinases is connected to several disease-conditions, most prominently cancer, Alzheimer’s and diabetes. Understanding the ...
    • Characterization of a neuraminic acid synthase from the psychrophilic organism Moritella viscosa 

      Berg, Tor Olav (Master thesis; Mastergradsoppgave, 2013-05-15)
      Sialic acids are family of nine carbon α-keto acids found to have important roles mammals and bacteria. They are negatively charged sugars which have found to play critical roles in the cognitive development, as well as being a part of the innate immune system and being targets for pathogens. Mammalian cells express sialic acids to confer self to the immune system, a trait being exploited by some ...
    • Reductions of barbituric acid based compounds 

      Kristoffersen, Stian (Master thesis; Mastergradsoppgave, 2013-05-15)
      Reductions of chalconoids with different para- substituents on the phenyl ring have been investigated in order to screen for kinase inhibitors with improved properties.
    • Biophysical characterization of the DYRK family. Studies on the kinases DYRK1A and DYRK1B 

      Alexeeva, Marina (Master thesis; Mastergradsoppgave, 2013-11-13)
      The dual-specificity tyrosine phosphorylation-regulated kinase family (DYRKs) has recently emerged as new therapeutic targets for different kinds of cancer and neurodegenerative diseases. In the latest studies it was shown that DYRK1B plays a key role in cancer cell survival, and its inhibition induces apoptosis of cancer cells. This thesis is about the biophysical characterization of DYRK1B and ...
    • On the Synthesis of Breitfussins. Toward the total synthesis of Breitfussin A and analogues 

      Guttormsen, Yngve (Master thesis; Mastergradsoppgave, 2014-05)
      The Breitfussins are a series of closely related heterocyclic compounds originated from the marine organism Thelia Breitfussi. The core is a 5(indol-3-yl)-2-(pyrrol-2-yl)oxazole, which has not been observed prior to its isolation in 2007. The divergence of the Breitfussins lies in the halogenation pattern and methoxy substitution. Breitfussin A is of synthetic interest because of its novel structural ...
    • Target characterization and ligand design directed at deoxyuridine 5'-triphospate nucleotidohydrolase 

      Liikanen, Laura Elina (Master thesis; Mastergradsoppgave, 2014-07-01)
      dUTPase is an important enzyme in DNA metabolism. It can be thought of as a gate keeper for apoptosis and is therefore an attractive target when trying to kill malign cells which cause disease in the human body. dUTPase has been found to be an important drug target in diseases such as cancer and malaria, to mention two. Due to problems with drug resistance in existing treatments, the search for new ...
    • MD simulations reveal how synthetic antimicrobial peptides interact with membrane models 

      Sarre, Birta Ravdna (Master thesis; Mastergradsoppgave, 2014-12-17)
      Since the discovery of antibiotics the extensive use in health care and agriculture has led to the development of resistant bacterial strains. Antimicrobial peptides (AMPs) exists in nature where they are believed to play an important role in the innate immune system in vertebrates. Due to their antibacterial properties and apparent ability to elicit very low bacterial resistance, researchers have ...
    • Vertical Diversity-Oriented Synthesis with Dibenzylideneacetones. Multivariate Optimization and Diversity Exploration. 

      Buhire, Phenias (Master thesis; Mastergradsoppgave, 2015-05-18)
      DOS was planned from dibenzylideneacetone to generate compound library with structural diversity, which can undergo further transformations. In the presented work, dibenzylideneacetone was cyclized under Robinson Annulation reaction. The resulting cyclization product was optimized using Multivariate response surface method. Response surface analysis helped to determine both significant variables ...
    • Novel Synthesis of Lipoxine A4 Analogues. Towards Allostric Modulators for Human Cannabinoid Receptor Type 1 

      Ismael, Aya (Master thesis; Mastergradsoppgave, 2015-11-15)
      The synthesis of the benzoid-based lipoxine A4 (LXA4) is the focus of this study specifically, the para substituted benzoid system. LXA4 is an endogenous agonist binding with high affinity to (ALXR) receptor that initiate it to display anti-inflammatory and antioxidant activities. Arachidonic acid is the cascade of LXA4 and its derivatives. These compounds belong to the biological active eicosanoids, ...
    • An Insight into the Aliivibrio genus. A comparative study on relationships and traits of species within the genus Aliivibrio 

      Klemetsen, Terje (Master thesis; Mastergradsoppgave, 2016-05-18)
      Few studies have emphasized on the genus Aliivibrio as a whole and lags behind the better known Vibrio. Nevertheless, the Aliivibrio has for several decades been associated with species expressing bioluminescence like the Aliivibrio fischeri, but has also been linked to costly diseases in the fish farming industry such as Aliivibrio salmonicida. In an attempt to gain insight in the genus on a ...
    • Characterization and structural analysis of class D β-lactamases: variants and mutants of OXA-type carbapenemases 

      Nesheim, Birgit Helene Berg (Master thesis; Mastergradsoppgave, 2016-05-18)
      The rise and spread of antibiotic resistant bacteria is posing a serious threat to the global health; antibiotic drugs are rendered ineffective and common infectious diseases become harder or impossible to treat. The beta-lactamase enzymes, with their ability to hydrolyze the beta-lactam antibiotics, are a major cause of resistant bacteria. The OXA-beta-lactamase enzymes are one of the most alarming ...
    • Synthesis of phorbazoles and breitfussins analogues 

      Abdelhady, Ahmed Mossad Mohamed (Master thesis; Mastergradsoppgave, 2016-05-18)
      Breitfussins are a group of a closely related heterocyclic compounds. They consist of a tetracyclic structure with an indole, an oxazole and a pyrrole. The breitfussins exhibit interesting biological activity and analogues synthesis and biological evaluation is ongoing. Phorbazoles have a structural similarity with breitfussins in which a phenol replaces the indole. As a part of this, synthesis of ...
    • Studies Towards the Synthesis of DKP Analogues. Investigations of Bis-lactim Ether Reactivity with Aldehydes and Ketones 

      Kadysjev, Arslan Maratovitsj (Master thesis; Mastergradsoppgave, 2016-05-19)
      A group of molecules with the name diketopiperazines (DKP) are called so, because of their diketopiperazine ring as the core structural unit. Mainly there are 3 types of diketopiperazies which only differ in in the position of the keto group, one type has the keto groups in 2,3- position; another in 2,5-; and the third in 2,6- position. The 2,5- isomer has attracted great interest, because of compounds ...
    • Microwave-assisted synthesis of heterocycles from aryldiazoacetates. 

      Kristoffersen, Tone (Master thesis; Mastergradsoppgave, 2017-11-15)
      A novel microwave-assisted method for generation of heterocycles have been explored. A range of 3,4 dihydroquinoxalin-2-ones have been prepared via an N-H insertion/cyclization cascade of dinucleophiles and aryldiazoacetates in moderate to good yields (12 - 80%). Reactions of aryldiazoacetates with o-phenylenediamine generated the best yields, while reactions with aliphatic and benzylic dinucleophiles ...
    • Rhenium- and technetium-oxo corroles: Toward corrole-based drugs and radiopharmaceuticals. 

      Einrem, Rune Finsås (Master thesis; Mastergradsoppgave, 2017-11-15)
      Corroles are an important class of contracted porphyrin analogues. Since quasi-one-pot syntheses of corroles were first reported in 1999, their coordination chemistry has been extensively studied. In the course of this thesis, the “periodic table of corroles” has been extended by two new elements, rhenium and technetium. Except from an accidental synthesis of an ReVO corrole via ring contraction ...
    • Solvent effect with Multiwavelets 

      Monstad, Rune Sørland (Master thesis; Mastergradsoppgave, 2017-11-15)
      This thesis contains the inclusion of solvent effect in the computational chemistry program MRChem. Water in water systems are of importance.
    • Enzyme mechanism, thermostability, and structural studies of OXA-48 like carbapenemases involved in antibiotic resistance 

      Thomassen, Ane Molden (Master thesis; Mastergradsoppgave, 2018-05-15)
      Antibiotic resistance is being recognized as a world-wide crisis in modern medicine, rapidly outpacing available treatment options. The serine-beta-lactamase OXA-48 was first identified from a carbapenem- and multidrug- resistant Klebsiella pneumoniae isolate in Turkey in 2001, and is now one of the most geographically widespread members of the class D beta-lactamases. OXA-48 like beta-lactamases ...