The rise and spread of antibiotic resistant bacteria is posing a serious threat to the global health; antibiotic drugs are rendered ineffective and common infectious diseases become harder or impossible to treat. The beta-lactamase enzymes, with their ability to hydrolyze the beta-lactam antibiotics, are a major cause of resistant bacteria. The OXA-beta-lactamase enzymes are one of the most alarming ...

Drug discovery and refinement for use in the industry is an important and lucrative field within chemistry. In this regard, computational chemistry has shown to be a valuable tool in assisting drug discovery. A set of intriguing proteins used in drug discovery are cold-adapted enzymes. These enzymes have a lower activation point which makes them of interest in industrial use. In this study, the ...

The last 18 months has shown the impact a single microorganism can have on society with the SARS-CoV-2 virus. This is not the only global threat on our health, with the World Health Organisation and other government agencies warning against the increase in antimicrobial resistance today. Antimicrobial peptides have been seen as a possible solution, as they are known to fight bacteria as a part of ...

Although the chemistry of corroles has grown spectacularly in recent years, the field has been marred by the lack of convenient protocols for demetalation of metallocorroles. In this thesis, I have developed a superior procedure for demetalating copper corroles with concentrated H2SO4 and 5-200 equiv FeCl2 or SnCl2. The yields obtained with this reductive procedure are generally substantially ...

Antibiotic resistance is being recognized as a world-wide crisis in modern medicine, rapidly outpacing available treatment options. The serine-beta-lactamase OXA-48 was first identified from a carbapenem- and multidrug- resistant Klebsiella pneumoniae isolate in Turkey in 2001, and is now one of the most geographically widespread members of the class D beta-lactamases. OXA-48 like beta-lactamases ...

Carbon-Carbon cross-coupling is a useful method that is used to connect carbons of different molecules to create a larger molecule. This is particularly powerful in synthesis of complicated molecules because it allows for different parts of the target molecule to be worked with separately before they are connected, which reduces the restrictions on the methods used during synthesis. One major drawback ...

To contribute to the fundamental picture of the electronic structure of high valent first row transition metal complexes, I have carried out a density functional study of two different macrocyclic ligand systems, corroles and corrolazines, with two different axial ligands, Ph and Cl and a number of different central ions, P(V), Cu(III), Mn(IV) and Fe(IV). DFT calculations on Fe(IV) and Mn(IV) corrole ...

The Vibrio cholerae bacteria resistance against introduction of new genetic material through transformation is caused mainly by a small extracellular or periplasmic endonuclease of type I, the VcEndA of 24.7 kDa coded by the dns gene, (Focareta et al, 1987; Focareta et al, 1991; Altermark et al, 2007b). The VcEndA homologues in other bacteria, Serratia marcescens (Timmins et al, 1973), Erwinia ...

Kliniske studier viser at inntak av omega-3 fettsyrene EPA, DPA og DHA kan bidra til å forebygge hjerte- og karsykdommer, redusere inflammasjon, påvirke sentralnervesystemets funksjon positivt og bidra til en rekke andre helsegevinster. Som en konsekvens har markedet for kommersielle omega-3 produkter økt de siste tiårene. Det ble kjøpt inn 10 produkter til dette studiet. Produktene baserte seg på ...

A novel microwave-assisted method for generation of heterocycles have been explored. A range of 3,4 dihydroquinoxalin-2-ones have been prepared via an N-H insertion/cyclization cascade of dinucleophiles and aryldiazoacetates in moderate to good yields (12 - 80%). Reactions of aryldiazoacetates with o-phenylenediamine generated the best yields, while reactions with aliphatic and benzylic dinucleophiles ...