• Enzyme mechanism, thermostability, and structural studies of OXA-48 like carbapenemases involved in antibiotic resistance 

      Thomassen, Ane Molden (Master thesis; Mastergradsoppgave, 2018-05-15)
      Antibiotic resistance is being recognized as a world-wide crisis in modern medicine, rapidly outpacing available treatment options. The serine-beta-lactamase OXA-48 was first identified from a carbapenem- and multidrug- resistant Klebsiella pneumoniae isolate in Turkey in 2001, and is now one of the most geographically widespread members of the class D beta-lactamases. OXA-48 like beta-lactamases ...
    • Exploring N-nucleophiles for diversification of a complex cyclohexenone scaffold 

      Brevik, Erlend Christopher (Master thesis; Mastergradsoppgave, 2019-06-05)
      In this thesis, synthesis of 3 different dibenzylideneacetone (DBA)-analogues and 4 different ethyl 2-oxo-6-phenyl-4-(2-phenylethenyl)-4-cyclohexene-1-carboxylate-analogues that have not been reported before were synthesized, as well as a range of analogues that have been reported before. Both symmetrical and unsymmetrical DBA-analogues were made. The yields of many of these reactions were low, but ...
    • Exploring Palladium-Catalyzed Cross-Coupling at Nitrile Groups 

      Funk, Cole (Master thesis; Mastergradsoppgave, 2022-05-16)
      Carbon-Carbon cross-coupling is a useful method that is used to connect carbons of different molecules to create a larger molecule. This is particularly powerful in synthesis of complicated molecules because it allows for different parts of the target molecule to be worked with separately before they are connected, which reduces the restrictions on the methods used during synthesis. One major drawback ...
    • Flexible membrane active antimicrobial tripeptides with stability towards chymotryptic degradation 

      Isaksen, Geir Villy (Master thesis; Mastergradsoppgave, 2010-06-14)
      In recent years antimicrobial peptides have gained a lot of attention due to their potential as a new generation of antibiotics combating the growing problem of antibiotic resistance. It is believed that the amphipathic structure of cationic peptides is a key feature for antimicrobial activity, and that this enables them to interact with the bacterial cell membrane. The conformational space of a ...
    • High valent transition metal corrole and corrolazine complexes. The question of noninnocent ligands 

      Tangen, Espen (Master thesis; Mastergradsoppgave, 2003-06-06)
      To contribute to the fundamental picture of the electronic structure of high valent first row transition metal complexes, I have carried out a density functional study of two different macrocyclic ligand systems, corroles and corrolazines, with two different axial ligands, Ph and Cl and a number of different central ions, P(V), Cu(III), Mn(IV) and Fe(IV). DFT calculations on Fe(IV) and Mn(IV) corrole ...
    • Identification, cloning and expressions of proteases from a cold adapted organism Aliivibrio salmonicida 

      Ather, Arjumand (Master thesis; Mastergradsoppgave, 2009-07-27)
      The work presented in this thesis provides an overview of molecular and structural biology projects and their related problems. The problems arises during these projects are common for most of the target proteins, with varying intensity of severity. The realization and identification of these problems and selection of their correct, best possible solution is an imperative step that might lead to ...
    • Inhibition study of Vibrio cholerae Endonuclease I 

      Sivertsen, Annfrid (Master thesis; Mastergradsoppgave, 2008-05-15)
      The Vibrio cholerae bacteria resistance against introduction of new genetic material through transformation is caused mainly by a small extracellular or periplasmic endonuclease of type I, the VcEndA of 24.7 kDa coded by the dns gene, (Focareta et al, 1987; Focareta et al, 1991; Altermark et al, 2007b). The VcEndA homologues in other bacteria, Serratia marcescens (Timmins et al, 1973), Erwinia ...
    • An Insight into the Aliivibrio genus. A comparative study on relationships and traits of species within the genus Aliivibrio 

      Klemetsen, Terje (Master thesis; Mastergradsoppgave, 2016-05-18)
      Few studies have emphasized on the genus Aliivibrio as a whole and lags behind the better known Vibrio. Nevertheless, the Aliivibrio has for several decades been associated with species expressing bioluminescence like the Aliivibrio fischeri, but has also been linked to costly diseases in the fish farming industry such as Aliivibrio salmonicida. In an attempt to gain insight in the genus on a ...
    • Karakterisering av kommersielle omega-3 produkter og utvikling av en ny metode for separasjon av lipidklasser med fast-fase ekstraksjon 

      Ovesen, Marte Stokvik (Master thesis; Mastergradsoppgave, 2012-11-15)
      Kliniske studier viser at inntak av omega-3 fettsyrene EPA, DPA og DHA kan bidra til å forebygge hjerte- og karsykdommer, redusere inflammasjon, påvirke sentralnervesystemets funksjon positivt og bidra til en rekke andre helsegevinster. Som en konsekvens har markedet for kommersielle omega-3 produkter økt de siste tiårene. Det ble kjøpt inn 10 produkter til dette studiet. Produktene baserte seg på ...
    • MD simulations reveal how synthetic antimicrobial peptides interact with membrane models 

      Sarre, Birta Ravdna (Master thesis; Mastergradsoppgave, 2014-12-17)
      Since the discovery of antibiotics the extensive use in health care and agriculture has led to the development of resistant bacterial strains. Antimicrobial peptides (AMPs) exists in nature where they are believed to play an important role in the innate immune system in vertebrates. Due to their antibacterial properties and apparent ability to elicit very low bacterial resistance, researchers have ...
    • Microwave-assisted synthesis of heterocycles from aryldiazoacetates. 

      Kristoffersen, Tone (Master thesis; Mastergradsoppgave, 2017-11-15)
      A novel microwave-assisted method for generation of heterocycles have been explored. A range of 3,4 dihydroquinoxalin-2-ones have been prepared via an N-H insertion/cyclization cascade of dinucleophiles and aryldiazoacetates in moderate to good yields (12 - 80%). Reactions of aryldiazoacetates with o-phenylenediamine generated the best yields, while reactions with aliphatic and benzylic dinucleophiles ...
    • A new fluorous-tagged porphyrinoid 

      Larsen, Simon (Master thesis; Mastergradsoppgave, 2012-08-16)
      The field of corrole chemistry has flourished over the past decade. Simple and high-yielding procedures have made the corrole ligand readily available, and several procedures on how to functionalize and otherwise modify corroles and their metal complexes have been reported. During an attempt to synthesize corrole from a fluorous tagged aromatic aldehyde a new porphyrinoid has been isolated from ...
    • Novel Synthesis of Lipoxine A4 Analogues. Towards Allostric Modulators for Human Cannabinoid Receptor Type 1 

      Ismael, Aya (Master thesis; Mastergradsoppgave, 2015-11-15)
      The synthesis of the benzoid-based lipoxine A4 (LXA4) is the focus of this study specifically, the para substituted benzoid system. LXA4 is an endogenous agonist binding with high affinity to (ALXR) receptor that initiate it to display anti-inflammatory and antioxidant activities. Arachidonic acid is the cascade of LXA4 and its derivatives. These compounds belong to the biological active eicosanoids, ...
    • Nær-orthogonale eksperimenter i organiske syntesereaksjoner 

      Simonsen, Geir (Master thesis; Mastergradsoppgave, 2010-04)
      I avhandlingen prøver jeg å vise hvordan nær-othhogonale eksperimenter kan brukes i screeningforsøk
    • On the synthesis of a fimbrolide 

      Descomps, Alexandre Pierre (Master thesis; Mastergradsoppgave, 2008-06-30)
      The present work is on the total synthesis of a natural compound found in a mixture of secondary metabolite produced by an alga nearby the cost of Australia. The target molecule, the 4-bromo-3-butyl-5-(dibromomethylene)furan-2(5H)-one, has not previously been proposed. The synthetic route described in this thesis uses cheap and readily available starting materials and the target is reached after six ...
    • On the Synthesis of Breitfussins. Toward the total synthesis of Breitfussin A and analogues 

      Guttormsen, Yngve (Master thesis; Mastergradsoppgave, 2014-05)
      The Breitfussins are a series of closely related heterocyclic compounds originated from the marine organism Thelia Breitfussi. The core is a 5(indol-3-yl)-2-(pyrrol-2-yl)oxazole, which has not been observed prior to its isolation in 2007. The divergence of the Breitfussins lies in the halogenation pattern and methoxy substitution. Breitfussin A is of synthetic interest because of its novel structural ...
    • On the synthesis of pyrylium salts 

      Strømme, Jann H. (Master thesis; Mastergradsoppgave, 2009-05-19)
      Abstract The present work is on the synthesis of a pyrylium salt, 8-hydroxy-2,4-diphenyl-5,6,7,8-tetrahydrochromenylium tetrafluoroborate, a precursor for interesting transition metal ligands. Different routes are presented with the aim of making an affordable precursor for the variety of syntheses possible from these versatile pyrylium salts. New findings include a preparative non optimized ...
    • Potassium on potassium-graphite as reagent in the paal-knorr synthesis of 2,5-dimethylthiophene. 

      Okungbowa, Richard Nosa (Master thesis; Mastergradsoppgave, 2009-05-27)
      This thesis describes a new principle for the synthesis of thiophene from diketone. Thiophene is a five-membered heterocyclic aromatic compound containing one sulphur atom. The thiophene structure can be found in certain natural products and is also incorporated in several pharmacologically active compounds. The procedure described in the thesis uses the combination of graphite and metallic ...
    • The preparation of N-methyliminodiacetic acid protected alkynyl boronates 

      O'Donnell, Michael (Master thesis; Mastergradsoppgave, 2010-06)
      The purpose of this work is to document the attempted syntheses of N-methyliminoacetic acid (MIDA) -protected alkynyl boronates according to procedures and methodologies that have been successfully employed in the syntheses of MIDA-protected alkyl, alkenyl, aryl and heteroaryl boronates. The rationale for the development of this class of MIDA-protected boronates is presented, both in terms of some ...
    • Protein-protein binding affinities calculated using the LIE method 

      Andberg, Tor Arne Heim (Master thesis; Mastergradsoppgave, 2011-11-15)
      Absolute binding free energies for the third domain of the turkey ovomucoid inhibitor in complex with Streptomyces griseus proteinase B and porcine pancreatic elastase has been calculated using the linear interaction energy method.