• Attempted syntheses of 1,3,4,6-tetrasubstituted-2,5-diketopiperazines using microwave assisted heating 

      Grineviciute, Laima (Master thesis; Mastergradsoppgave, 2012-06-08)
      Attempted syntheses of 1,3,4,6-tetrasubstituted-2,5-diketopiperazines using microwave assisted heating
    • Biophysical characterization of the DYRK family. Studies on the kinases DYRK1A and DYRK1B 

      Alexeeva, Marina (Master thesis; Mastergradsoppgave, 2013-11-13)
      The dual-specificity tyrosine phosphorylation-regulated kinase family (DYRKs) has recently emerged as new therapeutic targets for different kinds of cancer and neurodegenerative diseases. In the latest studies it was shown that DYRK1B plays a key role in cancer cell survival, and its inhibition induces apoptosis of cancer cells. This thesis is about the biophysical characterization of DYRK1B and ...
    • Biotech applications of protein kinase affinity interactions 

      Lund, Bjarte Aarmo (Master thesis; Mastergradsoppgave, 2013-05)
      Protein kinases provide one of the cell’s most important methods for signaling and control. 2% of the encoding genome consists of protein kinase genes, and from 10-50% of the proteins in the cell are phosphorylated at some point in the cell cycle. Malfunction of protein kinases is connected to several disease-conditions, most prominently cancer, Alzheimer’s and diabetes. Understanding the ...
    • Bonding in a triamidoamine-supported chromium(III) carbonyl 

      Nkeng, Agbor Moses (Master thesis; Mastergradsoppgave, 2008-05-15)
      Cr(III) metal ion in low spin triamidoamine-supported chromium(III) carbonyl complex {[(RN)3N]CrCO, 1} has a unique feature of S=1/2 being unusual for a Cr(III) metal ion, which is high spin with S=3/2 in most complexes and this gives us the basis for this theoretical study. The primary preoccupation has been to determine the electronic ground state and other low-energy state with much emphasis ...
    • Characterization and structural analysis of class D β-lactamases: variants and mutants of OXA-type carbapenemases 

      Nesheim, Birgit Helene Berg (Master thesis; Mastergradsoppgave, 2016-05-18)
      The rise and spread of antibiotic resistant bacteria is posing a serious threat to the global health; antibiotic drugs are rendered ineffective and common infectious diseases become harder or impossible to treat. The beta-lactamase enzymes, with their ability to hydrolyze the beta-lactam antibiotics, are a major cause of resistant bacteria. The OXA-beta-lactamase enzymes are one of the most alarming ...
    • Characterization of a neuraminic acid synthase from the psychrophilic organism Moritella viscosa 

      Berg, Tor Olav (Master thesis; Mastergradsoppgave, 2013-05-15)
      Sialic acids are family of nine carbon α-keto acids found to have important roles mammals and bacteria. They are negatively charged sugars which have found to play critical roles in the cognitive development, as well as being a part of the innate immune system and being targets for pathogens. Mammalian cells express sialic acids to confer self to the immune system, a trait being exploited by some ...
    • Demetalation of metallocorroles 

      Capar, Can (Master thesis; Mastergradsoppgave, 2008-10)
      Although the chemistry of corroles has grown spectacularly in recent years, the field has been marred by the lack of convenient protocols for demetalation of metallocorroles. In this thesis, I have developed a superior procedure for demetalating copper corroles with concentrated H2SO4 and 5-200 equiv FeCl2 or SnCl2. The yields obtained with this reductive procedure are generally substantially ...
    • Flexible membrane active antimicrobial tripeptides with stability towards chymotryptic degradation 

      Isaksen, Geir Villy (Master thesis; Mastergradsoppgave, 2010-06-14)
      In recent years antimicrobial peptides have gained a lot of attention due to their potential as a new generation of antibiotics combating the growing problem of antibiotic resistance. It is believed that the amphipathic structure of cationic peptides is a key feature for antimicrobial activity, and that this enables them to interact with the bacterial cell membrane. The conformational space of a ...
    • High valent transition metal corrole and corrolazine complexes. The question of noninnocent ligands 

      Tangen, Espen (Master thesis; Mastergradsoppgave, 2003-06-06)
      To contribute to the fundamental picture of the electronic structure of high valent first row transition metal complexes, I have carried out a density functional study of two different macrocyclic ligand systems, corroles and corrolazines, with two different axial ligands, Ph and Cl and a number of different central ions, P(V), Cu(III), Mn(IV) and Fe(IV). DFT calculations on Fe(IV) and Mn(IV) corrole ...
    • Identification, cloning and expressions of proteases from a cold adapted organism Aliivibrio salmonicida 

      Ather, Arjumand (Master thesis; Mastergradsoppgave, 2009-07-27)
      The work presented in this thesis provides an overview of molecular and structural biology projects and their related problems. The problems arises during these projects are common for most of the target proteins, with varying intensity of severity. The realization and identification of these problems and selection of their correct, best possible solution is an imperative step that might lead to ...
    • Inhibition study of Vibrio cholerae Endonuclease I 

      Sivertsen, Annfrid (Master thesis; Mastergradsoppgave, 2008-05-15)
      The Vibrio cholerae bacteria resistance against introduction of new genetic material through transformation is caused mainly by a small extracellular or periplasmic endonuclease of type I, the VcEndA of 24.7 kDa coded by the dns gene, (Focareta et al, 1987; Focareta et al, 1991; Altermark et al, 2007b). The VcEndA homologues in other bacteria, Serratia marcescens (Timmins et al, 1973), Erwinia ...
    • An Insight into the Aliivibrio genus. A comparative study on relationships and traits of species within the genus Aliivibrio 

      Klemetsen, Terje (Master thesis; Mastergradsoppgave, 2016-05-18)
      Few studies have emphasized on the genus Aliivibrio as a whole and lags behind the better known Vibrio. Nevertheless, the Aliivibrio has for several decades been associated with species expressing bioluminescence like the Aliivibrio fischeri, but has also been linked to costly diseases in the fish farming industry such as Aliivibrio salmonicida. In an attempt to gain insight in the genus on a ...
    • Karakterisering av kommersielle omega-3 produkter og utvikling av en ny metode for separasjon av lipidklasser med fast-fase ekstraksjon 

      Ovesen, Marte Stokvik (Master thesis; Mastergradsoppgave, 2012-11-15)
      Kliniske studier viser at inntak av omega-3 fettsyrene EPA, DPA og DHA kan bidra til å forebygge hjerte- og karsykdommer, redusere inflammasjon, påvirke sentralnervesystemets funksjon positivt og bidra til en rekke andre helsegevinster. Som en konsekvens har markedet for kommersielle omega-3 produkter økt de siste tiårene. Det ble kjøpt inn 10 produkter til dette studiet. Produktene baserte seg på ...
    • MD simulations reveal how synthetic antimicrobial peptides interact with membrane models 

      Sarre, Birta Ravdna (Master thesis; Mastergradsoppgave, 2014-12-17)
      Since the discovery of antibiotics the extensive use in health care and agriculture has led to the development of resistant bacterial strains. Antimicrobial peptides (AMPs) exists in nature where they are believed to play an important role in the innate immune system in vertebrates. Due to their antibacterial properties and apparent ability to elicit very low bacterial resistance, researchers have ...
    • A new fluorous-tagged porphyrinoid 

      Larsen, Simon (Master thesis; Mastergradsoppgave, 2012-08-16)
      The field of corrole chemistry has flourished over the past decade. Simple and high-yielding procedures have made the corrole ligand readily available, and several procedures on how to functionalize and otherwise modify corroles and their metal complexes have been reported. During an attempt to synthesize corrole from a fluorous tagged aromatic aldehyde a new porphyrinoid has been isolated from ...
    • Nær-orthogonale eksperimenter i organiske syntesereaksjoner 

      Simonsen, Geir (Master thesis; Mastergradsoppgave, 2010-04)
      I avhandlingen prøver jeg å vise hvordan nær-othhogonale eksperimenter kan brukes i screeningforsøk
    • On the synthesis of a fimbrolide 

      Descomps, Alexandre Pierre (Master thesis; Mastergradsoppgave, 2008-06-30)
      The present work is on the total synthesis of a natural compound found in a mixture of secondary metabolite produced by an alga nearby the cost of Australia. The target molecule, the 4-bromo-3-butyl-5-(dibromomethylene)furan-2(5H)-one, has not previously been proposed. The synthetic route described in this thesis uses cheap and readily available starting materials and the target is reached after six ...
    • On the Synthesis of Breitfussins. Toward the total synthesis of Breitfussin A and analogues 

      Guttormsen, Yngve (Master thesis; Mastergradsoppgave, 2014-05)
      The Breitfussins are a series of closely related heterocyclic compounds originated from the marine organism Thelia Breitfussi. The core is a 5(indol-3-yl)-2-(pyrrol-2-yl)oxazole, which has not been observed prior to its isolation in 2007. The divergence of the Breitfussins lies in the halogenation pattern and methoxy substitution. Breitfussin A is of synthetic interest because of its novel structural ...
    • On the synthesis of pyrylium salts 

      Strømme, Jann H. (Master thesis; Mastergradsoppgave, 2009-05-19)
      Abstract The present work is on the synthesis of a pyrylium salt, 8-hydroxy-2,4-diphenyl-5,6,7,8-tetrahydrochromenylium tetrafluoroborate, a precursor for interesting transition metal ligands. Different routes are presented with the aim of making an affordable precursor for the variety of syntheses possible from these versatile pyrylium salts. New findings include a preparative non optimized ...
    • Potassium on potassium-graphite as reagent in the paal-knorr synthesis of 2,5-dimethylthiophene. 

      Okungbowa, Richard Nosa (Master thesis; Mastergradsoppgave, 2009-05-27)
      This thesis describes a new principle for the synthesis of thiophene from diketone. Thiophene is a five-membered heterocyclic aromatic compound containing one sulphur atom. The thiophene structure can be found in certain natural products and is also incorporated in several pharmacologically active compounds. The procedure described in the thesis uses the combination of graphite and metallic ...