Now showing items 1-20 of 50

    • Adsorption of Organic Pollutants in Microplastic in the Arctic Ocean 

      Nordang, Unni Mette (Master thesis; Mastergradsoppgave, 2019-05-15)
      Oceans all over the world are housing large quantities of plastic pollution and persistent organic pollutants (POPs). Concerns regarding both of them having lipophilic characteristic that allows a successful partitioning of POPs to plastic if in contact in an aqueous medium, led to this study where the relationship between different types of plastic and POPs in the Arctic ocean are looked into. In ...
    • Antibiotic Resistance Breakers: Design and Synthesis of OXA-48 Inhibitors 

      Magnussen, Harald (Master thesis; Mastergradsoppgave, 2020-06-01)
      Antibiotic resistance is threatening the achievements of modern medicine and will evidentially lead to a situation, in which we stand helpless against common bacterial infections. The largest and most widely used group of antibiotics are the β-lactams. One of the major resistance determinants against β-lactam antibiotics is the expression of hydrolytic enzymes, called β-lactamases (BLs). The main ...
    • Attempted syntheses of 1,3,4,6-tetrasubstituted-2,5-diketopiperazines using microwave assisted heating 

      Grineviciute, Laima (Master thesis; Mastergradsoppgave, 2012-06-08)
      Attempted syntheses of 1,3,4,6-tetrasubstituted-2,5-diketopiperazines using microwave assisted heating
    • Biophysical characterization of the DYRK family. Studies on the kinases DYRK1A and DYRK1B 

      Alexeeva, Marina (Master thesis; Mastergradsoppgave, 2013-11-13)
      The dual-specificity tyrosine phosphorylation-regulated kinase family (DYRKs) has recently emerged as new therapeutic targets for different kinds of cancer and neurodegenerative diseases. In the latest studies it was shown that DYRK1B plays a key role in cancer cell survival, and its inhibition induces apoptosis of cancer cells. This thesis is about the biophysical characterization of DYRK1B and ...
    • Biotech applications of protein kinase affinity interactions 

      Lund, Bjarte Aarmo (Master thesis; Mastergradsoppgave, 2013-05)
      Protein kinases provide one of the cell’s most important methods for signaling and control. 2% of the encoding genome consists of protein kinase genes, and from 10-50% of the proteins in the cell are phosphorylated at some point in the cell cycle. Malfunction of protein kinases is connected to several disease-conditions, most prominently cancer, Alzheimer’s and diabetes. Understanding the ...
    • Bonding in a triamidoamine-supported chromium(III) carbonyl 

      Nkeng, Agbor Moses (Master thesis; Mastergradsoppgave, 2008-05-15)
      Cr(III) metal ion in low spin triamidoamine-supported chromium(III) carbonyl complex {[(RN)3N]CrCO, 1} has a unique feature of S=1/2 being unusual for a Cr(III) metal ion, which is high spin with S=3/2 in most complexes and this gives us the basis for this theoretical study. The primary preoccupation has been to determine the electronic ground state and other low-energy state with much emphasis ...
    • Characterization and structural analysis of class D β-lactamases: variants and mutants of OXA-type carbapenemases 

      Nesheim, Birgit Helene Berg (Master thesis; Mastergradsoppgave, 2016-05-18)
      The rise and spread of antibiotic resistant bacteria is posing a serious threat to the global health; antibiotic drugs are rendered ineffective and common infectious diseases become harder or impossible to treat. The beta-lactamase enzymes, with their ability to hydrolyze the beta-lactam antibiotics, are a major cause of resistant bacteria. The OXA-beta-lactamase enzymes are one of the most alarming ...
    • Characterization of a neuraminic acid synthase from the psychrophilic organism Moritella viscosa 

      Berg, Tor Olav (Master thesis; Mastergradsoppgave, 2013-05-15)
      Sialic acids are family of nine carbon α-keto acids found to have important roles mammals and bacteria. They are negatively charged sugars which have found to play critical roles in the cognitive development, as well as being a part of the innate immune system and being targets for pathogens. Mammalian cells express sialic acids to confer self to the immune system, a trait being exploited by some ...
    • Computational Studies of Selected Mutants of Shrimp Alkaline Phosphatase 

      Burkow, Magnus (Master thesis; Mastergradsoppgave, 2020-06-01)
      Drug discovery and refinement for use in the industry is an important and lucrative field within chemistry. In this regard, computational chemistry has shown to be a valuable tool in assisting drug discovery. A set of intriguing proteins used in drug discovery are cold-adapted enzymes. These enzymes have a lower activation point which makes them of interest in industrial use. In this study, the ...
    • Computer Modelling of an Enzyme Reference Reaction for Empirical Valence Bond Simulation 

      Abdulyaqeen, Uthman Seyi (Master thesis; Mastergradsoppgave, 2020-11-04)
      It is extensively recognized that an enzyme functions through reducing the energy of activation of its elemental reaction and the catalytic effect of an enzyme is as a result of a change in activation free energy obtained relative to a reference reaction in water of the same mechanism. In this study, chorismate mutase which is an enzyme that catalyzes biochemical reactions for chorismate conversion ...
    • Computer Simulations of Antimicrobial Tripeptides with Proteolytic Stability Towards Chymotrypsin 

      Barge, Bente Sirin (Master thesis; Mastergradsoppgave, 2019-12-05)
      The emerging crisis of antimicrobial resistance calls for the development of new therapeutic drugs. Antimicrobial peptides (AMPs), found in a variety of species as part of the host-defence mechanisms, serves as promising candidates for clinical use. Studies of well-known AMPs like lactoferrin have lead to the preparation of short cationic AMPs (CAPs) with broad spectrum antimicrobial activity against ...
    • Demetalation of metallocorroles 

      Capar, Can (Master thesis; Mastergradsoppgave, 2008-10)
      Although the chemistry of corroles has grown spectacularly in recent years, the field has been marred by the lack of convenient protocols for demetalation of metallocorroles. In this thesis, I have developed a superior procedure for demetalating copper corroles with concentrated H2SO4 and 5-200 equiv FeCl2 or SnCl2. The yields obtained with this reductive procedure are generally substantially ...
    • Development of a novel method for the analysis of acyl carnitine profile using liquid chromatography mass spectrometry 

      Spickova, Hana (Master thesis; Mastergradsoppgave, 2019-05-15)
      Carnitine is a low-molecular-weight compound that has an obligate role in the mitochondrial oxidation of long-chain fatty acids (acyl groups) and energy production. Therefore, acylcarnitines are essential diagnostic markers for complex diseases, fatty acid metabolism disorders, and disorders related to amino acids metabolism. Biochemical screening of the acylcarnitine profile is performed in clinical ...
    • Enzyme mechanism, thermostability, and structural studies of OXA-48 like carbapenemases involved in antibiotic resistance 

      Thomassen, Ane Molden (Master thesis; Mastergradsoppgave, 2018-05-15)
      Antibiotic resistance is being recognized as a world-wide crisis in modern medicine, rapidly outpacing available treatment options. The serine-beta-lactamase OXA-48 was first identified from a carbapenem- and multidrug- resistant Klebsiella pneumoniae isolate in Turkey in 2001, and is now one of the most geographically widespread members of the class D beta-lactamases. OXA-48 like beta-lactamases ...
    • Exploring N-nucleophiles for diversification of a complex cyclohexenone scaffold 

      Brevik, Erlend Christopher (Master thesis; Mastergradsoppgave, 2019-06-05)
      In this thesis, synthesis of 3 different dibenzylideneacetone (DBA)-analogues and 4 different ethyl 2-oxo-6-phenyl-4-(2-phenylethenyl)-4-cyclohexene-1-carboxylate-analogues that have not been reported before were synthesized, as well as a range of analogues that have been reported before. Both symmetrical and unsymmetrical DBA-analogues were made. The yields of many of these reactions were low, but ...
    • Exploring Palladium-Catalyzed Cross-Coupling at Nitrile Groups 

      Funk, Cole (Master thesis; Mastergradsoppgave, 2022-05-16)
      Carbon-Carbon cross-coupling is a useful method that is used to connect carbons of different molecules to create a larger molecule. This is particularly powerful in synthesis of complicated molecules because it allows for different parts of the target molecule to be worked with separately before they are connected, which reduces the restrictions on the methods used during synthesis. One major drawback ...
    • Flexible membrane active antimicrobial tripeptides with stability towards chymotryptic degradation 

      Isaksen, Geir Villy (Master thesis; Mastergradsoppgave, 2010-06-14)
      In recent years antimicrobial peptides have gained a lot of attention due to their potential as a new generation of antibiotics combating the growing problem of antibiotic resistance. It is believed that the amphipathic structure of cationic peptides is a key feature for antimicrobial activity, and that this enables them to interact with the bacterial cell membrane. The conformational space of a ...
    • High valent transition metal corrole and corrolazine complexes. The question of noninnocent ligands 

      Tangen, Espen (Master thesis; Mastergradsoppgave, 2003-06-06)
      To contribute to the fundamental picture of the electronic structure of high valent first row transition metal complexes, I have carried out a density functional study of two different macrocyclic ligand systems, corroles and corrolazines, with two different axial ligands, Ph and Cl and a number of different central ions, P(V), Cu(III), Mn(IV) and Fe(IV). DFT calculations on Fe(IV) and Mn(IV) corrole ...
    • Identification, cloning and expressions of proteases from a cold adapted organism Aliivibrio salmonicida 

      Ather, Arjumand (Master thesis; Mastergradsoppgave, 2009-07-27)
      The work presented in this thesis provides an overview of molecular and structural biology projects and their related problems. The problems arises during these projects are common for most of the target proteins, with varying intensity of severity. The realization and identification of these problems and selection of their correct, best possible solution is an imperative step that might lead to ...
    • Inhibition study of Vibrio cholerae Endonuclease I 

      Sivertsen, Annfrid (Master thesis; Mastergradsoppgave, 2008-05-15)
      The Vibrio cholerae bacteria resistance against introduction of new genetic material through transformation is caused mainly by a small extracellular or periplasmic endonuclease of type I, the VcEndA of 24.7 kDa coded by the dns gene, (Focareta et al, 1987; Focareta et al, 1991; Altermark et al, 2007b). The VcEndA homologues in other bacteria, Serratia marcescens (Timmins et al, 1973), Erwinia ...