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dc.contributor.authorJenssen, Marte
dc.contributor.authorKristoffersen, Venke
dc.contributor.authorMotiram-Corral, Kumar
dc.contributor.authorIsaksson, Johan
dc.contributor.authorRämä, Teppo
dc.contributor.authorAndersen, Jeanette Hammer
dc.contributor.authorHansen, Espen
dc.contributor.authorØstnes Hansen, Kine
dc.date.accessioned2022-01-24T09:28:47Z
dc.date.available2022-01-24T09:28:47Z
dc.date.issued2021-12-13
dc.description.abstractAs part of our search for bioactive metabolites from understudied marine microorganisms, the new chlorinated metabolite chlovalicin B (1) was isolated from liquid cultures of the marine basidiomycete Digitatispora marina, which was collected and isolated from driftwood found at Vannøya, Norway. The structure of the novel compound was elucidated by spectroscopic methods including 1D and 2D NMR and analysis of HRMS data, revealing that 1 shares its molecular scaffold with a previously isolated compound, chlovalicin. This represents the first compound isolated from the Digitatispora genus, and the first reported fumagillin/ovalicin-like compound isolated from Basidiomycota. Compound 1 was evaluated for antibacterial activities against a panel of five bacteria, its ability to inhibit bacterial biofilm formation, for antifungal activity against Candida albicans, and for cytotoxic activities against malignant and non-malignant human cell lines. Compound 1 displayed weak cytotoxic activity against the human melanoma cell line A2058 (~50% survival at 50 µM). No activity was detected against biofilm formation or C. albicans at 50 µM, or against bacterial growth at 100 µM nor against the production of cytokines by the human acute monocytic leukemia cell line THP-1 at 50 µMen_US
dc.identifier.citationJenssen, Kristoffersen, Motiram-Corral, Isaksson, Rämä, Andersen, Hansen, Østnes Hansen. Chlovalicin B, a Chlorinated Sesquiterpene Isolated from the Marine Mushroom Digitatispora marina. Molecules. 2021;26(24)en_US
dc.identifier.cristinIDFRIDAID 1970064
dc.identifier.doi10.3390/molecules26247560
dc.identifier.issn1420-3049
dc.identifier.urihttps://hdl.handle.net/10037/23774
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.ispartofJenssen, M. (2022). Bioprospecting of marine microorganisms for the discovery of antibacterial compounds - Isolation, structure elucidation and bioactivity assessment of marine microbial natural products. (Doctoral thesis). <a href=https://hdl.handle.net/10037/24722>https://hdl.handle.net/10037/24722</a>.
dc.relation.journalMolecules
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/BIOTEK2021/269425/Norway/DL: Digital discovery of antimicrobial molecules from marine Arctic resources with reduced risk of triggering resistance//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleChlovalicin B, a Chlorinated Sesquiterpene Isolated from the Marine Mushroom Digitatispora marinaen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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