Blar i forfatter Artikler, rapporter og annet (Administrasjonen) "Sæther, Thomas"

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    • Molecular modelling, synthesis, and biological evaluations of a 3,5-disubstituted isoxazole fatty acid analogue as a PPARα-selective agonist 

      Arnesen, Henriette; Haj-Yasein, Nadia N.; Tungen, Jørn E.; Soedling, Helen; Matthews, Jason; Paulsen, Steinar M.; Nebb, Hilde I.; Sylte, Ingebrigt; Hansen, Trond Vidar; Sæther, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-19)
      The peroxisome proliferator activated receptors (PPARs) are important drug targets in treatment of metabolic and inflammatory disorders. Fibrates, acting as PPARα agonists, have been widely used lipid-lowering agents for decades. However, the currently available PPARα targeting agents show low subtype-specificity and consequently a search for more potent agonists have emerged. In this study, previously ...

    • Synthesis and biological evaluations of marine oxohexadecenoic acids: PPARα/γ dual agonism and anti-diabetic target gene effects 

      Sæther, Thomas; Paulsen, Steinar M; Tungen, Jørn Eivind; Vik, Anders; Aursnes, Marius; Holen, Torgeir; Hansen, Trond Vidar; Nebb, Hilde Irene (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-18)
      Obesity and associated disorders such as metabolic syndrome and type 2 diabetes (T2D) have reached epidemic proportions. Several natural products have been reported as Peroxisome Proliferator-Activated Receptor (PPAR) agonists, functioning as lead compounds towards developing new anti-diabetic drugs due to adverse side effects of existing PPAR drugs. We recently isolated and identified (7E)-9-oxoh ...