Blar i utgivelsesdato Doktorgradsavhandlinger (NT-fak)

Viser treff 41-60 av 290

    • Design and Evaluation of a Medical Microwave Radiometer for Observing Temperature Gradients Subcutaneously in the Human Body 

      Klemetsen, Øystein (Doctoral thesis; Doktorgradsavhandling, 2012-02-01)
      The topic covered in this thesis is medical temperature measurement of subcutaneous parts of human tissue with use of microwave radiometry. Radiometry is a completely non-invasive, non-toxic and relatively inexpensive sensing modality. The radiometric technique is based on the measurement of electromagnetic noise power emitted by lossy materials. The method has explicit low investment costs and ...

    • Protein kinase selectivity mechanisms and structure assisted drug discovery 

      Pflug, Alexander (Doctoral thesis; Doktorgradsavhandling, 2012-02-24)
      Protein fosforylering er en av de viktigste intracellulære signaltransduksjonsmekanismer i eukaryote og er involvert i nesten alle cellulære prosesser. Avvikende kinase aktivitet kan forårsake mange alvorlige sykdommer som diabetes og kreft. Bruk av små molekyler for å modulere protein kinase aktivitet er nå en validert metode for behandling av slike sykdommer. Men imidlertid har kliniske studier ...

    • Palaeoenvironment of the Barents Sea during the last deglaciation and Holocene : processes and timing 

      Rüther, Denise Christina (Doctoral thesis; Doktorgradsavhandling, 2012-03-01)
      The scope of this PhD thesis is twofold: Firstly, processes, patterns and timing of the last deglaciation in the Barents Sea are reconstructed and secondly, depositional conditions on the Barents shelf during Holocene are elucidated. This cumulative PhD thesis encompasses an introductory part and five papers - three as first-author and two as co-author. Three papers are focused on the most prominent ...

    • Scale-space methodology applied to spectral feature detection, multinormality testing and the k-sample problem, and wavelet variance analysis 

      Hindberg, Kristian (Doctoral thesis; Doktorgradsavhandling, 2012-03-23)
      The number of scale-space statistical algorithms has been greatly increased over the last 15 years. The concept originated from computer vision, introduced in Lindeberg (1994). The seminal paper by Chaudhuri and Marron (1999) brought the scale-space concept into smoothing of curves and kernel density estimation through the SiZer tool. By using all relevant smoothing bandwidths, i.e., the scale part, ...

    • Arctic Ocean warmings from the last glaciation to the present : implementing and assessing the reliability of planktic foraminiferal paleoreconstructions 

      Zamelczyk, Katarzyna Agnieszka (Doctoral thesis; Doktorgradsavhandling, 2012-05-11)
      The aim of the PhD study was to use planktic foraminifera to elucidate paleoceanographic variability and the preservation state of calcium carbonate in the eastern Fram Strait throughout the last 30,000 years. Sediment cores were studied using a multiproxy approach which included analyzing planktic and benthic foraminiferal fauna distribution patterns, measurements of stable isotopes (δ18O, δ13C), ...

    • Synthetic aperture ultrasound imaging with application to interior pipe inspection 

      Skjelvareid, Martin Hansen (Doctoral thesis; Doktorgradsavhandling, 2012-09-07)
      This thesis is concerned with synthetic aperture focusing of ultrasonic pulse-echo measurements, with application to multilayered media and cylindrical structures. The work is motivated by the need for accurate methods for non-destructive testing of pipelines, particularly water distribution pipelines. By improving the lateral resolution in ultrasonic measurements, the synthetic aperture algorithms ...

    • A multidisciplinary subsurface analysis of mud volcanoes and salt diapirs in European Seas 

      Perez-Garcia, Carolina (Doctoral thesis; Doktorgradsavhandling, 2012-09-13)

    • Benthic foraminifera in an Arctic fjord : recent distribution and fauna of the last two millennia 

      Jernas, Patrycja Ewa (Doctoral thesis; Doktorgradsavhandling, 2012-09-13)
      The main objective of the PhD study was to improve the knowledge about the ecology of the benthic foraminiferal faunas thus increasing the precision of benthic foraminifera as indicators for modern and past Arctic fjord and shelf environments. The investigation of living (stained) benthic foraminifera assemblages in Kongsfjorden (western Svalbard) was performed on inter-annual and seasonal time ...

    • Synthesis of a novel class of antitubercular peptidomimetics based on β-aminoboronates. 

      Gorovoy, Alexey (Doctoral thesis; Doktorgradsavhandling, 2012-11-16)
      The unique properties of antimicrobial peptides have attracted the attention of chemists since the 1970’s. This class of compounds provides additional tools in the treatment of infections and the work described in this thesis was therefore focused on the synthesis of short peptidomimetics on the basis of modified amino acids and evaluation of their antimicrobial activity. The compounds of choice ...

    • Display Scale in a ‘Document’ perspective : size matters 

      Olsen, Bernt Ivar (Doctoral thesis; Doktorgradsavhandling, 2012-11-26)
      The work summarized in this thesis has its basis in technology to support human collaboration. I have investigated how large, high-resolution display (LaHiRD) technology, implemented using display wall technology (large, tiled displays implemented as one coherent display surface) could support clinical work. Hence, I have worked with the topic of technological support for human collaboration (or ...

    • Ice Shelf - Ocean Interaction in the Eastern Weddell Sea, Antarctica 

      Hattermann, Tore (Doctoral thesis; Doktorgradsavhandling, 2012-12-10)
      This thesis investigates the interaction of the Antarctic ice shelves along the coast of Dronning Maud Land with the ocean circulation in the Eastern Weddell Sea. A set of direct oceanic observations below the Fimbul Ice Shelf, which were acquired during three Antarctic field seasons in the austral summers 2009/10, 2010/11 and 2011/12, is a central element of the presented work. This new oceanographic ...

    • Processes and dynamics during deglaciation of a polar continental shelf. Examples from the marine-based Barents Sea Ice Sheet 

      Bjarnadottir, Lilja Run (Doctoral thesis; Doktorgradsavhandling, 2012-12-20)
      The main objective of this PhD thesis was to reconstruct the pattern and main processes of the last deglaciation of the Barents Sea Ice Sheet. The thesis consists of an introductory part and five papers. The conclusions presented in the papers were based on data acquired with a suite of marine geophysical and geological methods, including multibeam-swath bathymetry data, chirp data, airgun and sparker ...

    • Optical Forces, Waveguides and Micro Raman Spectroscopy 

      Løvhaugen, Pål (Doctoral thesis; Doktorgradsavhandling, 2012-12-21)
      Optical waveguides are used to confine propagating light. In a dielectric waveguide, a small part of the propagating light travels along and just outside the waveguide surface. This evanescent field can interact with objects on the waveguide surface. Two effects of this light-matter interaction are presented, optical forces and Raman scattering. Optical forces are caused by changes in the momentum ...

    • Design, Synthesis and Biological Activity of Small α-Aminoboron Containing Peptidomimetics 

      Gozhina, Olga Vladimirovna (Doctoral thesis; Doktorgradsavhandling, 2013-01-18)
      Antimicrobial peptides (AMPs) are a special group of small amphipathic peptides (which hold both hydrophilic and hydrophobic regions) composed of different amino acids and produced by all living organisms as a part of innate immunity. With the increasing microbial resistance to traditional antibiotics the need for unconventional therapeutic has become crucial. This thesis deals with the design ...

    • Understanding and predicting one- and two-photon absorption properties of molecular complexes 

      Steindal, Arnfinn Hykkerud (Doctoral thesis; Doktorgradsavhandling, 2013-01-22)
      This thesis presents the development of theoretical models for the calculations of one- and two-photon absorption, and computational studies on solvated systems and biomolecules. The photon-absorbing chromophore is described by density functional theory, while the effects of the surroundings are taken into account by means of polarizable embedding models. The theory and implementation of a three-layered ...

    • Geophysical characterizations of fluid flow and gas-hydrate systems of the NW-Svalbard and SW-Barents Sea margins 

      Rajan, Anupama (Doctoral thesis; Doktorgradsavhandling, 2013-02-06)
      The thesis consists of four parts and its four main objectives are: (1) to establish a potential link between serpentinization beneath a young sedimented-ocean ridge and carbon release and gas hydrate formation directly above it, (2) to understand the coexistence of free gas and gas-hydrate and to image the geophysical evidence for a geologically controlled gas hydrate, fluid migration pathway and ...

    • Model-Driven Software Development for Continuity of Care Information Systems - Toolchain design and evaluation 

      Walderhaug, Ståle (Doctoral thesis; Doktorgradsavhandling, 2013-03-13)
      This thesis summarizes six years of design, development and evaluation of a model- driven development toolchain and design of software services for continuity of care. The overall research method has been design science, with a strong focus on creating and evaluating the core artefact: the ModelHealth Toolchain. Three iterations with toolchain design and assessments were deemed necessary to be able ...

    • Multitemporal Analysis of Multipolarization Synthetic Aperture Radar Images for Robust Surface Change Detection 

      Akbari, Vahid (Doctoral thesis; Doktorgradsavhandling, 2013-06-07)
      This thesis addresses two approaches for change detection from multipolarization, multilooked SAR images: a post-classification comparison and a direct change detection. We consider the complete workflow associated with performing post-classification change detection from time series of multipolarization SAR (PolSAR) images acquired with different imaging geometries and polarimetric configurations. ...

    • Acyl homoserine lactone signaling in members of the Vibrionaceae family 

      Purohit, Amit (Doctoral thesis; Doktorgradsavhandling, 2013-06-13)
      Bacterial cell to cell communication, which involves regulation of gene expression in response to cell density, is defined as Quorum Sensing (QS). In QS small molecule signals are produced, which regulate their own production and are defined as auto-inducers. These signals are received by receiver proteins and in response certain genes are regulated directly or indirectly by these receiver proteins. ...

    • Development of novel renin inhibitors and interaction of antimicrobial and cytotoxic peptides with plasma proteins. A drug discovery study 

      Sivertsen, Annfrid (Doctoral thesis; Doktorgradsavhandling, 2013-06-14)
      In this study we have explored the structure activity relationship of molecules with potential as novel drug classes toward current medical challenges as hypertension, cancer and infections caused by antibiotic resistant bacteria. Direct renin inhibitors have for a long time been an interesting group of potential anti-hypertension drugs, as they inhibit the first and rate-limiting step in the signal ...