Now showing items 1-20 of 1139

    • 14th International Symposium on Cells of the Hepatic Sinusoid 

      Smedsrød, Bård (Book; Bok, 2008-08-31)
      Abstract book of the symposium
    • 17β-estradiol promotes extracellular vesicle release and selective miRNA loading in ERα-positive breast cancer 

      Drula, Rares; Pardini, Barbara; Fu, Xiao; De Los Santos, Mireia Cruz; Jurj, Ancuta; Pang, Lan; El-Daly, Sherien M.; Fabris, Linda; Knutsen, Erik; Dragomir, Mihnea P.; Bayraktar, Recep; Li, Yongfeng; Chen, Meng; Del Vecchio, Filippo; Berland, Léa; Dae, Jessica; Fan, Daniel; Shimizu, Masayoshi; Tran, Anh M.; Barzi, Mercedes; Pioppini, Carlotta; Gutierrez, Angelica M.; Ivan, Cristina; Meas, Salyna; Hall, Carolyn S.; Alahari, Suresh K.; Berindan-Neagoe, Ioana; Fabbri, Muller; Lucci, Anthony; Arun, Banu; Anfossi, Simone; Calin, George A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-30)
      The causes and consequences of abnormal biogenesis of extracellular vesicles (EVs) are not yet well understood in malignancies, including in breast cancers (BCs). Given the hormonal signaling dependence of estrogen receptor–positive (ER+) BC, we hypothesized that 17β-estradiol (estrogen) might influence EV production and microRNA (miRNA) loading. We report that physiological doses of 17β-estradiol ...
    • 3-Weeks of Exercise Training Increases Ischemic-Tolerance in Hearts From High-Fat Diet Fed Mice 

      Boardman, Neoma Tove; Rossvoll, Line; Lund, Jim; Hafstad, Anne Dragøy; Aasum, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-02)
      Physical activity is an efficient strategy to delay development of obesity and insulin resistance, and thus the progression of obesity/diabetes-related cardiomyopathy. In support of this, experimental studies using animal models of obesity show that chronic exercise prevents the development of obesity-induced cardiac dysfunction (cardiomyopathy). Whether exercise also improves the tolerance to ...
    • The 5-HT1E receptor. Receptor structure and ligand interactions. 

      Gabrielsen, Mari (Master thesis; Mastergradsoppgave, 2006-12-08)
      5-HT (5-Hydroxytryptamine; Serotonin) is the neurotransmitter with the highest number of known receptors in humans, and the importance of 5-HT is also reflected in the number of species using 5-HT as a signalling molecule and the number of 5-HT receptors found within each species. 15 human 5-HT receptors have at this date been characterised and classified into seven 5-HT receptor families. Six of ...
    • Abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the Tromsø study. 

      Forsdahl, Signe Helene; Solberg, Steinar; Singh, Kulbir; Jacobsen, Bjarne Koster (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
      Background: In a population-based study in Tromsø, Norway, the authors assessed whether an abdominal aortic aneurysm (AAA) or the maximal infrarenal aortic diameter in a non-aneurismal aorta influence total and cardiovascular disease (CVD) mortality. Methods: A total of 6640 men and women, aged 25–84 years, were included in a 10-year mortality follow-up: 345 subjects with a diagnosed AAA and ...
    • Acculturation and self-rated health among Arctic indigenous peoples : a population-based cross-sectional study 

      Eliassen, Bent-Martin; Braaten, Tonje; Melhus, Marita; Hansen, Ketil Lenert; Broderstad, Ann Ragnhild (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Acculturation is for indigenous peoples related to the process of colonisation over centuries as well as the on-going social transition experienced in the Arctic today. Changing living conditions and lifestyle affect health in numerous ways in Arctic indigenous populations. Self-rated health (SRH) is a relevant variable in primary health care and in general public health assessments and monitoring. ...
    • Accumulation of stable full-length circular group i intron RNAs during heat-shock 

      Andersen, Kasper L.; Beckert, Bertrand; Masquida, Benoît; Johansen, Steinar Daae; Nielsen, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-31)
      Group I introns in nuclear ribosomal RNA of eukaryotic microorganisms are processed by splicing or circularization. The latter results in formation of full-length circular introns without ligation of the exons and has been proposed to be active in intron mobility. We applied qRT-PCR to estimate the copy number of circular intron RNA from the myxomycete Didymium iridis . In ...
    • Acquired loss of renal nuclease activity is restricted to DNase I and is an organselective feature in murine lupus nephritis 

      Seredkina, Natalya; Rekvik, Ole Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      An acquired loss of renal DNaseI has recently been shown to promote transformation of mild mesangial lupus nephritis into membrano-proliferative end-stage organ disease. In this study, we analyzed expression profiles of DNaseI in other organs of lupus-prone (NZBxNZW)F1 mice during disease progression to determine if silencing of the renal DNaseI gene is an organ specific feature or if loss of ...
    • Active and passive smoking and the risk of myocardial infarction in 24,968 men and women during 11 year of follow-up: the Tromsø Study 

      Iversen, Birgitte; Jacobsen, Bjarne Koster; Løchen, Maja-Lisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Active smoking is a well-established risk factor for myocardial infarction, but less is known about the impact of passive smoking, and possible sex differences in risk related to passive smoking. We investigated active and passive smoking as risk factors for myocardial infarction in an 11-year follow-up of 11,762 men and 13,206 women included in the Tromsø Study. There were a total of 769 and 453 ...
    • Activity-Based Protein Profiling in Methicillin-Resistant Staphylococcus aureus Reveals the Broad Reactivity of a Carmofur-Derived Probe 

      Uddin, Md Jalal; Overkleeft, Hermen S.; Lentz, Christian Stephan (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-08)
      Activity-based protein profiling is a powerful chemoproteomic technique to detect active enzymes and identify targets and off-targets of drugs. Here, we report the use of carmofur- and activity-based probes to identify biologically relevant enzymes in the bacterial pathogen Staphylococcus aureus. Carmofur is an anti-neoplastic prodrug of 5-fluorouracil and also has antimicrobial and anti-biofilm ...
    • Acupoint Stimulation for Fibromyalgia: A Systematic Review of Randomized Controlled Trials 

      Cao, Huijuan; Li, Xun; Han, Mei; Liu, Jianping (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background. Acupoint stimulation is popular for treatment of fibromyalgia though there is lack of comprehensive evaluation of current clinical evidence for its effect and safety. Objective. To systematically review the beneficial effects and safety of acupoint stimulation for fibromyalgia. Methods. We searched six electronic databases for randomized trials on acupoint stimulation for treatment ...
    • Acupuncture Adverse Events in China: A Glimpse of Historical and Contextual Aspects 

      Birch, Stephen; Alræk, Terje; Norheim, Arne Johan (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      The article by He and colleagues, ‘‘Adverse Events Following Acupuncture: A Systematic Review of the Chinese Literature for the Years 1956–2010’’ is an important and timely contribution. In this commentary, the article is reviewed and issues are highlighted about how to interpret and contextualize the results of their study. While their review has been well performed, certain areas have been ...
    • Administration of tetradecylthioacetic acid (TTA) stimulates myocardial fatty acid oxidation despite having a lipid-lowering effect 

      Severson, DL; Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Clarke, Kieran; Hagve, Martin; Berge, Rolf; Lund, trine; Larsen, Terje; Aasum, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2009)
    • Advanced methods and novel biomarkers in autoimmune diseases ‑ a review of the recent years progress in systemic lupus erythematosus 

      Fenton, Kristin Andreassen; Pedersen, Hege Lynum (Journal article; Tidsskriftartikkel, 2023-06-23)
      There are several autoimmune and rheumatic diseases affecting different organs of the human body. Multiple sclerosis (MS) mainly affects brain, rheumatoid arthritis (RA) mainly affects joints, Type 1 diabetes (T1D) mainly affects pancreas, Sjogren’s syndrome (SS) mainly affects salivary glands, while systemic lupus erythematosus (SLE) affects almost every organ of the body. Autoimmune diseases are ...
    • Age- and Gender-Associated Staphylococcus aureus spa Types Found among Nasal Carriers in a General Population: the Tromsø Staph and Skin Study. 

      Sangvik, Maria; Olsen, Renate Slind; Olsen, Karina; Simonsen, Gunnar Skov; Furberg, Anne-Sofie; Sollid, johanna u ericson (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Staphylococcus aureus nasal carriers risk autoinfection; however, knowledge about the factors that make specific strains successful colonizers is limited. This study was undertaken to identify the most successful S. aureus clones in nasal carriers and compare their distribution among host groups. The population structure of S. aureus isolates from healthy adults was investigated by spa typing 1,981 ...
    • Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy 

      Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Protein aggregation is a continuous process in our cells. Some proteins aggregate in a regulated manner required for different vital functional processes in the cells whereas other protein aggregates result from misfolding caused by various stressors. The decision to form an aggregate is largely made by chaperones and chaperone-assisted proteins. Proteins that are damaged beyond repair are degraded ...
    • Agnoprotein of polyomavirus BK interacts With proliferating cell nuclear antigen and inhibits DNA replication 

      Gerits, Nancy; Johannessen, Mona; Tümmler, Conny; Walquist, Mari; Kostenko, Sergiy; Snapkov, Igor; van Loon, Barbara; Ferrari, Elena; Hübscher, Ulrich; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-01)
      Background: The human polyomavirus BK expresses a 66 amino-acid peptide referred to as agnoprotein. Though mutants lacking agnoprotein are severely reduced in producing infectious virions, the exact function of this peptide remains incompletely understood. To elucidate the function of agnoprotein, we searched for novel cellular interaction partners. <p>Methods: Yeast-two hybrid assay was performed ...
    • Agreement between diagnoses of childhood lymphoma assigned in Uganda and by an international reference laboratory 

      Orem, J; Sandin, S; Weibull, CE; Odida, M; Wabinga, H; Mbidde, EK; Wabwire-Mangen, F; Meijer, CJ; Middeldorp, JM; Weiderpass, Elisabete (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Correct diagnosis is key to appropriate treatment of cancer in children. However, diagnostic challenges are common in low-income and middle-income countries. The objective of the present study was to assess the agreement between a clinical diagnosis of childhood non-Hodgkin lymphoma (NHL) assigned in Uganda, a pathological diagnosis assigned in Uganda, and a pathological diagnosis assigned in The ...
    • Alpha-actinin-binding antibodies in relation to systemic lupus erythematosus and lupus nephritis 

      Becker-Merok, Andrea; Kalaaji, Manar; Haugbro, Kaia; Nikolaisen, Cathrin; Nilsen, Kirsten; Rekvig, Ole Petter; Nossent, Johannes C (Journal article; Tidsskriftartikkel; Peer reviewed, 2006-10-24)
      This study investigated the overall clinical impact of anti-α- actinin antibodies in patients with pre-selected autoimmune diseases and in a random group of anti-nuclear antibody (ANA)- positive individuals. The relation of anti-α-actinin antibodies with lupus nephritis and anti-double-stranded DNA (anti-dsDNA) antibodies represented a particular focus for the study. Using a cross-sectional ...
    • AlphaFold-multimer predicts ATG8 protein binding motifs crucial for autophagy research 

      Olsvik, Hallvard Lauritz; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-08)
      Proteins are structural and executing macromolecules essential for life in all biological systems. Insight into proteins structures is required for detailed mechanistic understanding of how they work and solve different tasks. The ability to predict three-dimensional (3D) protein structures from primary sequence information has therefore been an open research question for more than 50 years. The ...