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High expression of PDGFR-β in prostate cancer stroma is independently associated with clinical and biochemical prostate cancer recurrence
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-24)
Due to a lack of sufficient diagnostic tools to predict aggressive disease, there is a significant overtreatment of patients with prostate cancer. Platelet derived growth factors (PDGFs) and their receptors (PDGFRs) are key regulators of mesenchymal cells in the tumor microenvironment, and has been associated with unfavorable outcome in several other cancers. Herein, we aimed to investigate the ...
Evaluation of the proliferation marker Ki-67 in a large prostatectomy cohort.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-15)
The tumor proliferation index marker Ki-67 is strongly associated with tumor cell proliferation,
growth and progression, and is widely used in routine clinicopathological investigation.
Prostate cancer is a complex multifaceted and biologically heterogeneous disease, and
overtreatment of localized, low volume indolent tumors, is evident. Here, we aimed to
assess Ki-67 expression and related ...
The prognostic role of immune checkpoint markers programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) in a large, multicenter prostate cancer cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-01)
Programmed cell death protein 1 (PD-1) and its ligand Programmed death ligand
1 (PD-L1) have gained massive attention in cancer research due to recent availability
and their targeted antitumor effects. Their role in prostate cancer is still undetermined.
We constructed tissue microarrays from prostatectomy specimens from 535 prostate
cancer patients. Following validation of antibodies, ...
Stromal Expression of MiR-21 Predicts Biochemical Failure in Prostate Cancer Patients with Gleason Score 6
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
Prognostic Impact of Jab1, p16, p21, p62, Ki67 and Skp2 in Soft Tissue Sarcomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
Purpose The purpose of this study is to clarify the prognostic significance of expression of Jab1, p16, p21, p62, Ki67 and Skp2 in soft tissue sarcomas (STS). Optimised treatment of STS requires better identification of high risk patients who will benefit from adjuvant therapy. The prognostic significance of Jab1, p16, p21, p62, Ki67 and Skp2 in STS has not been sufficiently investigated. ...
Prognostic impact of CD57, CD68, M-CSF, CSF-1R, Ki67 and TGF-beta in soft tissue sarcomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
BACKGROUND: Prognostic markers in curable STS may have the potential to guide therapy after surgical resection. The purpose of this study was to clarify the prognostic impact of the presence of cells and growth factors belonging to the innate immune system in soft tissue sarcomas (STS). The significance of macrophages (CD68), their growth factor macrophage colony-stimulating factor (M-CSF), its ...
Prognostic impact of Skp2, ER and PGR in male and female patients with soft tissue sarcomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
BACKGROUND: S-phase kinase-associated protein 2 (Skp2) is a member of mammalian F-box proteins. The purpose of this study is to clarify the prognostic significance of expression of Skp2 related to gender, estrogen receptor (ER) and progesterone receptor (PGR) in soft tissue sarcomas (STS). Optimized treatment of STS requires better identification of high-risk patients who will benefit from adjuvant ...
Prognostic Impact of Lymphocytes in Soft Tissue Sarcomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
The purpose of this study was to clarify the prognostic significance of lymphocyte infiltration in soft tissue sarcomas (STS). Prognostic markers in potentially curable STS should guide therapy after surgical resection. The immune status at the time of resection may be important, but the prognostic significance of tumor infiltrating lymphocytes is controversial as the immune system has conflicting ...
The impact of MET, IGF-1, IGF1R expression and EGFR mutations on survival of patients with non-small-cell lung cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-25)
Introduction: <br>
To compare the efficacy of silver in situ hybridization (SISH) and immunohistochemistry (IHC) in detecting MET and IGF1R alterations and to investigate their prevalence and prognostic significance. A possible correlation between MET receptor expression, MET gene alterations and the two most frequent occurring EGFR gene mutations was also investigated.
<br>Materials and ...
Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-12)
Noninvasive biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis and disease risk stratification are greatly needed. We conducted a nested case-control study within the Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate prediagnostic microRNAs (miRs) as biomarkers of subsequent PDAC risk. A panel of eight miRs (miR-10a, -10b, -21-3p, -21-5p, -30c, -106b, ...