Now showing items 1-10 of 84
Analysis of glomerular target structures for nephritic anti-dsDNA antibodies playing central roles in lupus nephritis
(Master thesis; Mastergradsoppgave, 2008-05)
Systemic lupus erythematosus is an autoimmune disease characterized by the presence of autoantibodies towards nuclear antigens. Sub-populations of anti-dsDNA antibodies have the potential to bind in the kidney and thereby induce nephritis, but there is no definite distinction that separates non-pathogenic from pathogenic antibodies. There must be parameters that determine anti-dsDNA antibody binding, ...
Risikovurdering; import og spredning av tarmpatogene bakterier med krydder og urter
(Research report; Forskningsrapport, 2007-09-26)
Forbruket av krydder i Norge øker og ligger per i dag på vel ½ kg per person og år (2006). Forbruket hos oss er imidlertid fortsatt langt lavere enn i enkelte andre industriland (eksempelvis USA med et forbruk på 1,6 kilo per person og år) og vil derfor sannsynligvis fortsatt øke ganske betydelig. Også antall ulike kryddertyper øker, parallelt med økende interesse for ”eksotisk” (ikke minst asiatisk) ...
Site-specific reverse splicing of a HEG-containing group I intron in ribosomal RNA
(Journal article; Tidsskriftartikkel; Peer reviewed, 2005)
The myxomycete Didymium iridis (isolate Panama 2) contains a mobile group I intron named Dir.S956-1 after position 956 in the nuclear small subunit (SSU) rRNA gene. The intron is efficiently spread through homing by the intron-encoded homing endonuclease I-DirI. Homing endonuclease genes (HEGs) usually spread with their associated introns as a unit, but infrequently also spread independent ...
Complete mitochondrial genome sequences of the Arctic Ocean codfishes Arctogadus glacialis and Boreogadus saida reveal oriL and tRNA gene duplications
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008-05-27)
We have determined the complete mitochondrial genome sequences of the codWshes Arctogadus glacialis and Boreogadus saida (Order Gadiformes, Family Gadidae). The 16,644 bp and 16,745 bp mtDNAs, respectively, contain the same set of 37 structural genes found in all vertebrates analyzed so far. The gene organization is conserved compared to other Gadidae species, but with one notable exception. ...
A third approach to gene prediction suggests thousands of additional human transcribed regions
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-03)
The identification and characterization of the complete ensemble of genes is a main goal of deciphering the digital information stored in the human genome. Many algorithms for computational gene prediction have been described, ultimately derived from two basic concepts: (1) modeling gene structure and (2) recognizing sequence similarity. Successful hybrid methods combining these two concepts have ...
Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2007-09-06)
Background: Multidrug resistance is a particular limitation to cancer chemotherapy, antibiotic treatment and HIV medication. The ABC (ATP binding cassette) transporters human P-glycoprotein (ABCB1) and the human MRP5 (ABCC5) are involved in multidrug resistance. Results: In order to elucidate structural and molecular concepts of multidrug resistance, we have constructed a molecular model of the ...
Fatal inanition in reindeer (Rangifer tarandus tarandus) : pathological findings in completely emaciated carcasses
(Journal article; Tidsskriftartikkel; Peer reviewed, 2007-09-28)
Background: In a project to determine the causes of winter mortality in reindeer in Finnmark County, northern Norway, the most frequent diagnosis turned out to be complete emaciation, despite several of the reindeer having been given silage for up to 4 weeks before they died. The present paper describes autopsy results and other findings in these animals. Methods: Autopsies were made of 32 ...
Cyanobacterial ribosomal RNA genes with multiple, endonuclease-encoding group I introns
(Journal article; Tidsskriftartikkel; Peer reviewed, 2007-09-08)
Background: Group I introns are one of the four major classes of introns as defined by their distinct splicing mechanisms. Because they catalyze their own removal from precursor transcripts, group I introns are referred to as autocatalytic introns. Group I introns are common in fungal and protist nuclear ribosomal RNA genes and in organellar genomes. In contrast, they are rare in all other ...
A mitogenomic approach to the taxonomy of pollocks. Theragra chalcogramma and T. finnmarchica represent one single species
(Journal article; Tidsskriftartikkel; Peer reviewed, 2007-06-07)
Background: The walleye pollock (Theragra chalcogramma) and Norwegian pollock (T. finnmarchica) are confined to the North Pacific and North Atlantic Oceans, respectively, and considered as distinct species within the family Gadidae. We have determined the complete mtDNA nucleotide sequence of two specimens of Norwegian pollock and compared the sequences to that of 10 specimens of walleye pollock ...
Improvement of wound healing by water-filtered infrared-A (wIRA) in patients with chronic venous stasis ulcers of the lower legs including evaluation using infrared thermography
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008)