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dc.contributor.authorJoseph, Josepha
dc.contributor.authorSvartberg, Johan
dc.contributor.authorNjølstad, Inger
dc.contributor.authorSchirmer, Henrik
dc.date.accessioned2011-09-23T08:02:09Z
dc.date.available2011-09-23T08:02:09Z
dc.date.issued2010
dc.description.abstractMany incident cases of type 2 diabetes do not fulfill the metabolic syndrome, which accordingly has been questioned both as a research and clinical tool. The aim of this study was to determine differences in risk factors for type 2 diabetes between groups with high or low metabolic score. The study population were 26,093 men and women attending the Tromsø Study in 1994, followed through 2005, and who did not have diabetes when entering the study. A total of 492 incident cases of type 2 diabetes were registered. A metabolic score was defined according to a modified version of the National Cholesterol Education Program Adult Treatment Panel III. For those fulfilling C 3 metabolic score criteria, increasing age, body mass index (BMI), triglycerides and a family history of diabetes were independent predictors. Age, BMI, and triglycerides predicted type 2 diabetes more strongly in subjects with low metabolic score, whereas high HDL cholesterol was not protective in this low risk group. The risk associated with a positive family history was unaffected by level of metabolic score. In addition smoking, low education and in men also physical inactivity were independent risk factors only in those with low metabolic score. Adding these nonmetabolic risk factors increased correct classification from an ROC area of 77.2 to 87.1% (P value\0.0001). One half of the incident cases of type 2 diabetes were missed by using high metabolic score for risk predictionen
dc.descriptionThis article is part of Josepha Joseph's doctoral thesis, which is available in Munin at <a href=http://hdl.handle.net/10037/2968>http://hdl.handle.net/10037/2968</a>en
dc.identifier.citationEuropean journal of epidemiology, vol. 26, number 2, 117-124en
dc.identifier.doidoi: 10.1007/s10654-010-9540-7
dc.identifier.urihttps://hdl.handle.net/10037/3626
dc.identifier.urnURN:NBN:no-uit_munin_3342
dc.language.isoengen
dc.publisherSpringeren
dc.rights.accessRightsopenAccess
dc.subjectmetabolic syndromeen
dc.subjectlow metabolic scoreen
dc.subjecthigh metabolic scoreen
dc.subjectnon-metabolic risk factorsen
dc.subjectreceiver operating characteristicsen
dc.subjecttype 2 diabetesen
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Endocrinology: 774en
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774en
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Preventive medicine: 804en
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Forebyggende medisin: 804en
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803en
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803en
dc.titleRisk factors for type 2 diabetes in groups stratified according to metabolic syndrome : a 10-year follow-up of The Tromsø Studyen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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