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miR-126 as a prognostic marker in non-GIST soft tissue sarcoma
(Master thesis; Mastergradsoppgave, 2014-04-10)
The aim of the study was to study the prognostic impact of miRNAs in non-GIST soft tissue sarcoma. The method used was microarray-based miRNA expression profiling of all verified human miRNAs on a selected number of samples. Selection criteria was time of survival (long and short). Then, the significance of miR-126 expression for disiease-specific survival in the total patient cohort of non-GIST ...
Molecular targets and biological effects of PAX6 in lung cancer
(Master thesis; Mastergradsoppgave, 2013-05-15)
Lung cancer is by far the leading cause of cancer-related mortality worldwide regardless of sex, and has a dismal overall 5-year survival rate of approximately 15%. More than 85% of all lung cancers are non-small cell lung cancer (NSCLC), and about 50% of these are adenocarcinomas. Targeted treatment has shown promising results in treating certain types of NSCLC, but the overall survival is still ...