Clinical reasoning is a core activity in everyday clinical work, but is also a well-developed field of research with scholarly papers, reviews, books, conferences and medical curriculum activities. In this body of knowledge, and although it remains a complex construct [1], clinical reasoning is generally defined as the cognitive processes and mental structures that physicians mobilise to decide on ...

Noncommunicable diseases are among the most significant health threats in our society, being cardiovascular diseases (CVD) the most prevalent. Because of the severity and prevalence of these illnesses, early detection and prevention are critical for reducing the worldwide health and economic burden. Though machine learning (ML) methods usually outperform conventional approaches in many domains, class ...

<p><i>Background</i>: Earlier work has described videoconferencing technologies, peripheral equipment, organizational models, human relations, purposes, goals and roles as versatile, multifaceted, and those used differently in different clinical practices. Knowledge about benefits and challenges connected to specific characteristics of services are lacking. A 2005 systematic review of published ...

Neuroblastoma is a pediatric cancer of the developing sympathetic nervous system. High-risk neuroblastoma patients typically undergo an initial remission in response to treatment, followed by recurrence of aggressive tumors that have become refractory to further treatment. The need for biomarkers that can select patients not responding well to therapy in an early phase is therefore needed. In this ...

This qualitative study explores Sami and non-Sami clinicians’ assumptions about Sami culture and their experiences in providing mental health services to Sami patients. The aim is to better understand and improve the ways in which culture is incorporated into mental health services in practice. Semi-structured interviews were conducted with 20 clinicians in mental health outpatient clinics in the ...

Denne studien har undersøkt Escherichia coli resistente for kinoloner, en bredpektret gruppe antibiotika. Målet har vært å finne ut hvorfor disse bakteriene oftere er resistente mot andre antoibiotikagrupper. Studiet er basert på molekylærgenetisk analyser - herunder klonal analyse, plasmidanalyser og undersøkelse av resistensgener. Resultatene viser at kinolonresistente Escherichia coli er ofte ...

Chronic myelogenous leukaemia is a monoclonal hematopoetic stem cell disorder characterised by the t(9;22) translocation and results in the constitutively activated Bcr-Abl tyrosine kinase. Since the tyrosine kinase activity of the Bcr-Abl fusion protein is the causative molecular event in CML, targeting the tyrosine kinase activity appears to be an attractive therapeutic strategy. Imatinib, ...

A linezolid-resistant, vancomycin-susceptible Enterococcus faecium strain was isolated from 3 patients who had not received linezolid. The first patient was hospitalized in the same hospitals and wards as the 2 following patients. The E. faecium isolates were resistant to linezolid (minimum inhibitory concentration 8–32 mg/l), ampicillin, and high levels of gentamicin. Resistance to linezolid was ...

Background:<br>The relation of a single risk factor with atherosclerosis is established. Clinically we know of risk factor clustering within individuals. Yet, studies into the magnitude of the relation of risk factor clusters with atherosclerosis are limited. Here, we assessed that relation.<br>Methods:<br>Individual participant data from 14 cohorts, involving 59,025 individuals were used in this ...

Digitalization of healthcare is done through development and delivery of health information technology, mobile health, wearable devices, telehealth, telemedicine, health portals, personalized medicine, or in other words – ehealth. Ehealth solutions are expected to improve the treatment process, improved safety, efficiency and quality, as well as empowerment of both patients and healthcare professionals. ...