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    • Development of an analytical method for detection and quantification of cannabis and cannabinoid analogues in urine 

      Steinshamn, Eirin Berge (Master thesis; Mastergradsoppgave, 2010-05-20)
      Cannabis is a drug mainly consumed for its euphoric effects; users may become happy, careless and relaxed. The direct effects of cannabis in sports are performance decreasing, but cannabis can be used as a doping agent due to its relaxing properties. For these reasons, cannabinoids are prohibited in sports during competition by the World Anti-Doping Agency (WADA). In the context of the fight ...
    • Development of an assay for determining PDE5 enzyme activity and for screening of potential inhibitors of the PDE5 enzyme in cancer cells 

      Granaas, Magnus Løkke (Master thesis; Mastergradsoppgave, 2013-05-15)
      PDE5 is a member of the superfamily of phosphodiesterases, and it is identified as the main mechanism for breakdown of cGMP in mammals. Sildenafil is a well-known inhibitor of the PDE5 enzyme and it is also shown that sildenafil inhibits the ABCC5 transporter pump. ABCC5 is a member of the superfamily of ABC-transporters, and identified as an important transporter for mediating the cellular efflux ...
    • Development of an in vitro model to study compromised skin: pigskin versus the Phospholipid Vesicle-based Permeation Assay 

      Fedreheim, Elena (Master thesis; Mastergradsoppgave, 2013-05-20)
      When the skin barrier is reduced, penetration of topical and transdermal drugs could potentially be enhanced and the risk of systemic effects is increased. The studies analysing penetration through intact or diseased skin are often limited by the variability in obtaining specimens of representative skin. The phospholipid vesicle-based permeation assay is an artificial barrier mimicking human stratum ...
    • Development of bioactive peptides from the parasitic hookworm as potential treatments for autoimmune diseases 

      Baumann, Markus (Master thesis; Mastergradsoppgave, 2012-06)
      Hookworms are parasitic nematodes that reside in the intestines of their host, where they feed on host blood. The large number of infected individuals and the long survival time inside the host makes it interesting to study the immunomodulatory activities of the hookworms. The excretory/secretory (ES) products are suspected to be responsible for these effects. One aim of this project was to fractionate ...
    • Development of biomimetic phospholipid vesicle-based permeation assays (PVPA) as screening tool in drug development 

      Naderkhani, Elenaz (Doctoral thesis; Doktorgradsavhandling, 2015-04-17)
      Although several routes of administration can be utilized to bring a drug to the desired site of action, oral administration is still the most important and prevalent route of administration, due to its cost efficiency, convenience and patient compliance. A prerequisite for successful oral therapy is the ability of a drug to cross the gastrointestinal barrier. Over the past two decades, the ...
    • Development of chitosan-coated liposomes for improved therapy of vaginal infections: clotrimazole as model drug 

      Jøraholmen, May Wenche Bakke (Master thesis; Mastergradsoppgave, 2012-05)
      For many drugs the vaginal route of administration is favorable, particularly for local therapy of specific gynecological diseases such as vaginal infections. A large variety of pharmaceutical preparations have been developed for vaginal delivery, nevertheless, the efficiency of currently available dosage forms is often limited by their poor retention time at the vaginal site. Physiological changes ...
    • Development of COFRADIC HPLC system for proteomics. Sorting of N-terminal peptides 

      Banki, Maryam Ghazi Ali (Master thesis; Mastergradsoppgave, 2014-05-20)
      Proteomics, the study of the proteins constituting the proteome, has featured in the past few years as an essential tool in a number of diverse areas of therapeutic research for detection of the initial stage of a disease, for consideration of therapy response and for disintegrating fundamental pathophysiological mechanisms. Proteomics has a wide range of applications such as diabetes research, ...
    • Development of early life gut resistome and mobilome across gestational ages and microbiota-modifying treatments 

      Bargheet, Ahmed; Klingenberg, Claus Andreas; Esaiassen, Eirin; Hjerde, Erik; Cavanagh, Jorunn Pauline; Bengtsson-Palme, Johan; Pettersen, Veronika K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-13)
      Background - Gestational age (GA) and associated level of gastrointestinal tract maturation are major factors driving the initial gut microbiota composition in preterm infants. Besides, compared to term infants, premature infants often receive antibiotics to treat infections and probiotics to restore optimal gut microbiota. How GA, antibiotics, and probiotics modulate the microbiota’s core ...
    • The development of electrospun chloramphenicol containing wound dressing 

      Murugaiah, Anjanah (Master thesis; Mastergradsoppgave, 2021-05-11)
      Wound healing is among the most complex processes in the human body that is greatly coordinated with a focus to rebuild tissue integrity and restore the skin´s protective barrier. The normal healing process is disrupted in chronic wounds, leading to delayed wound healing due to several underlying factors such as aging, obesity, and diabetes. Among chronic wounds 50 % are infected and up to 78 % of ...
    • Development of grip strength during the first year after stroke 

      Stock, Roland; Thrane, Gyrd; Askim, Torunn; Anke, Audny; Mork, Paul Jarle (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-08)
      <p><i>Objective</i>: To assess recovery of grip strength during the first year post-stroke.</p> <p><i>Design</i>: Exploratory study on a subsample of patients participating in the Norwegian Constraint-Induced Movement Therapy trial.</p> <p><i>Subjects</i>: Eleven patients (mean age 59.1 years; 3 women) with mild to moderate stroke were recruited 7–29 days post-stroke.</p> <p><i>Methods</i>: ...
    • Development of Hypertension and Diabetes Mellitus, and Associated Factors, Among Adult HIV Patients in Ethiopia 

      Tegene, Yadessa; Mengesha, Selamawit; Putman, Erin; Toma, Alemayehu; Spigt, Marcus (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-16)
      Background: Medical improvements and increased access to treatment have turned HIV from a highly fatal disease into a treatable and controllable disease. With the improvement in lifespan, HIV patients face increasing morbidity and mortality from chronic comorbidities (hypertension and diabetes mellitus). There is, nevertheless, a paucity of information on the scale of HIV noncommunicable disease ...
    • Development of improved bendamustin-liposomes 

      Evjen, Tove Julie (Master thesis; Mastergradsoppgave, 2007-05)
      Bendamustin is an alkylating anticancer agent which is currently in routine use for the treatment of different types of cancer. The drug is very unstable in serum due to hydrolysis; the half life of the first part of the serum elimination curve is about 6-10 minutes. The rapid degradation of the drug in serum impairs its cytostatic action within a short period of time, and frequent application of ...
    • Development of liposomal curcumin for vaginal drug delivery 

      Hussain, Haider (Master thesis; Mastergradsoppgave, 2010-06-16)
      Curcumin (I), demethoxy curcumin (II) and bisdemethoxy curcumin (III) are commonly called curcuminoids, and derived products from the spice, turmeric. It has reported numerous of therapeutic activities including, anti-inflammatory, and anticancer properties. The aim of the current study was to develop a formulation which can overcome the limitation of curcumin being so poorly soluble in aqueous ...
    • Development of liposomal formulation for green tea catechins targeted for the treatment of vaginal inflammation 

      Trønnes, Johanne Naper (Master thesis; Mastergradsoppgave, 2012-05-20)
      Green tea catechins are well known for their antioxidative and anti-inflammatory properties. In this connection, catechins are thought to be potential candidates in prevention and treatment of diseases caused by oxidative damage. In addition, catechins have been shown to be effective in the treatment of genital warts. However, they exhibit low bioavailability and poor solubility, which limits their ...
    • Development of muds for improved vaginal therapy 

      Meland, Hilde-Gunn (Master thesis; Mastergradsoppgave, 2011-06-01)
      Bacterial vaginosis is a common cause of vaginitis, condition often treated with oral metronidazole. However, due to unpleasant side effects, patient compliance is often reduced. Vaginal tablet with bioadhesive properties could enable a prolonged residence time and a sustained release of a drug at the site of infection. Vagina as a drug administration site is attractive due to high surface area, ...
    • Development of new tissue culture protocols for enrichment of CD4 T cells associated with neonatal alloimmune thrombocytopenia 

      Killie, Ida Løken (Master thesis; Mastergradsoppgave, 2010-11-15)
      Neonatal alloimmune thrombocytopenia (NAIT) is most commonly caused by destruction of foetal platelets by maternal antibodies reactive to human platelet antigen (HPA)-1a. The activation of antigen-primed B cells to differentiate to antibody-secreting plasma cells usually requires help from CD4 T cells. The strong association between anti-HPA-1a-production and the MHC allele HLA-DRB3*0101 supports ...
    • Development of orodispersible films: A new age-appropriate dosage form for children 

      Betoko, Evrard Louis Alain Brice (Master thesis; Mastergradsoppgave, 2015-05-18)
      In the recent years, governmental institutions have given incentives to the pharmaceutical industry in order to develop age-appropriate dosage forms for pediatric use. This has resulted in an interest in design of new and improved dosage form for pediatric patients. One of the many recent approaches is to take advantages of ODFs. Taste masking is a crucial step in the design of not only ODFs but all ...
    • Development of osmotically active liposomes for nose-to-brain drug delivery 

      Wu, Iren Yeeling (Doctoral thesis; Doktorgradsavhandling, 2019-11-22)
      The brain as a drug target site remains a pharmaceutical challenge in spite of numerous efforts to enhance drug delivery to the brain. Nasal drug administration has gained interest among researchers, especially in the last decade, as it provides direct drug access into the brain. However, the nasal mucus and the surrounding environment often limit the use of nose as the administration site. Drug ...
    • Development of post-pericardiotomy syndrome is preceded by an increase in pro-inflammatory and a decrease in anti-inflammatory serological markers 

      Snefjellå, Nora; Lappegård, Knut Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The post-pericardiotomy syndrome (PPS) is a common complication after cardiac surgery, occuring in 10-40% of patients. PPS may prolong hospitalization, and even serious complications like tamponade and constrictive pericarditis may occur. Early diagnosis and treatment may reduce morbidity. In 50 patients transferred to our hospital after cardiac surgery we found an increase in pro-inflammatory and ...
    • Development of quantitative assay for simultaneous measurement of purine metabolites and creatinine in biobanked urine by liquid chromatography-tandem mass spectrometry 

      Svistounov, Dmitri; Solbu, Marit Dahl; Jenssen, Trond Geir; Mathisen, Ulla Dorte; Hansen, Terkel; Elgstøen, Katja Benedikte Prestø; Zykova, Svetlana (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-20)
      Purine metabolism is essential for all known living creatures, including humans in whom elevated serum concentration of purine break-down product uric acid (UA) is probably an independent risk factor for mortality, type 2 diabetes and cardiovascular events. An automated multiplex assay that measures several purine metabolites could therefore prove useful in many areas of medical, veterinary and ...