Bacterial vaginosis is a common cause of vaginitis, condition often treated with oral metronidazole. However, due to unpleasant side effects, patient compliance is often reduced. Vaginal tablet with bioadhesive properties could enable a prolonged residence time and a sustained release of a drug at the site of infection. Vagina as a drug administration site is attractive due to high surface area, ...

In the recent years, governmental institutions have given incentives to the pharmaceutical industry in order to develop age-appropriate dosage forms for pediatric use. This has resulted in an interest in design of new and improved dosage form for pediatric patients. One of the many recent approaches is to take advantages of ODFs. Taste masking is a crucial step in the design of not only ODFs but all ...

The post-pericardiotomy syndrome (PPS) is a common complication after cardiac surgery, occuring in 10-40% of patients. PPS may prolong hospitalization, and even serious complications like tamponade and constrictive pericarditis may occur. Early diagnosis and treatment may reduce morbidity. In 50 patients transferred to our hospital after cardiac surgery we found an increase in pro-inflammatory and ...

Due to the lack of sunlight during the winter, people living in the arctic are unable to produce vitamin D3; hence deficiency of such vitamin is common in this part of the world. Given the geographic location of Norway, development of vitamin D deficiency is a common phenomenon. As vitamin D deficiency has become a public health issue, understanding the effects is vital for clinical implications. ...

Background. Maternal alloantibodies against HPA-1a can cross placenta, opsonize foetal platelets, and induce neonatal alloimmune thrombocytopenia (NAIT). In a study of 100, 448 pregnant women in Norway during 1995–2004, 10.6% of HPA-1a negative women had detectable anti-HPA-1a antibodies. Design and Methods. A possible correlation between the maternal ABO blood group phenotype, or underlying genotype, ...

We developed three ultra-high pressure liquid chromatography coupled to mass spectrometry detection (UHPLCMS/MS) methods to quantify 25 antihypertensive drugs in serum samples. Patient-reported drug lists were collected, and drug concentrations were analysed in samples from 547 patients, half with uncontrolled hypertension, and all treated with ≥ 2 antihypertensive drugs. For sample preparation, ...

Findings from previous cross-sectional studies showed that while toddlers around their first birthday imitate selectively, that is, they systematically omit some kinds of target action steps or they copy only the goal, but not the means of the modeled actions, older toddlers imitate more exactly. The aim of the present article is to provide longitudinal evidence for this developmental trend and to ...

Previous research has demonstrated that age-related decline in cognitive and sensorimotor functions are related to dexterity and instrumental activities of daily living (IADL). Few studies have closely investigated the association between dexterity and cognitive functions. The purpose of this study was to explore possible differences in dexterity, cognition and IADL function across a group of mild ...

Purpose The purpose of the research is to develop an application that will support diabetes management in general practice. The research solution was implied to allow general practitioner to see advanced represented data that was measured and recorded into mobile diabetes diary by patients with diabetes. Motivation The development of mHealth applications for patients with diabetes has large ...

Innledning Diabetes i svangerskapet er assosiert med økt risiko for alvorlige komplikasjoner for mor og barn. Formålet med oppgaven var å studere forskjeller i prevalens av preeklampsi, keisersnitt og føtal makrosomi mellom gravide/fødende kvinner med diabetes mellitus type 1 (T1DM), diabetes mellitus type 2 (T2DM) eller svangerskapsdiabetes (GDM), og en kontrollgruppe av friske gravide/fødende ...