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Distriktslege eller sykehusspesialist? Studenters holdninger
(Master thesis; Mastergradsoppgave, 2005-09-21) -
Distriktssykepleie i Nord Norge. “Hvilke særegenheter innebærer utøvelsen av distriktssykepleie i Nord Norge?”
(Master thesis; Mastergradsoppgave, 2020-12-09)<p>Bakgrunn: Internasjonal forskning beskriver at sykepleierne i distriktene har spesielle utfordringer og krav til handlings- og beredskapskompetanse i sin yrkesutøvelse enn sykepleiere i byene. Dette understøttes av nyere norsk forskning som også har identifisert et behov for større bevissthet rundt den rurale arbeidskonteksten og mer sykepleieforskning på temaet i Norge. <p>Hensikt: Studiens ... -
The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)The mitogen-activated protein kinase-activated protein kinase MK5 is ubiquitously expressed in vertebrates and is implicated in cell proliferation, cytoskeletal remodeling, and anxiety behavior. This makes MK5 an attractive drug target. We tested several diterpenoid alkaloids for their ability to suppress MK5 kinase activity. We identified noroxoaconitine as an ATP competitor that inhibited the ... -
Divergent Regulation of Decidual Oxidative-Stress Response by NRF2 and KEAP1 in Preeclampsia with and without Fetal Growth Restriction
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-10)Utero-placental development in pregnancy depends on direct maternal–fetal interaction in the uterine wall decidua. Abnormal uterine vascular remodeling preceding placental oxidative stress and placental dysfunction are associated with preeclampsia and fetal growth restriction (FGR). Oxidative stress is counteracted by antioxidants and oxidative repair mechanisms regulated by the transcription factor ... -
Diversity and anti-fungal susceptibility of Norwegian Candida glabrata clinical isolates
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-08)BACKGROUND: Increasing numbers of immunocompromised patients have resulted in greater incidence of invasive fungal infections with high mortality. Candida albicans infections dominate, but during the last decade, Candida glabrata has become the second highest cause of candidemia in the United States and Northern Europe. Reliable and early diagnosis, together with appropriate choice of antifungal ... -
Diverting stomas reduce reoperation rates for anastomotic leak but not overall reoperation rates within 30 days after anterior rectal resection: a national cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-24)Purpose A diverting stoma is commonly formed to reduce the rate of anastomotic leak following anterior resection with anastomosis, although some studies question this strategy. The aim of this study was to assess the leak rates and overall complication burden after anterior resection with and without a diverting stoma.<p> <p>Methods A 5-year national cohort with prospectively registered data of ... -
DNA Damage Response
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-19) -
DNA hypo-methylation facilitates anti-inflammatory responses in severe ulcerative colitis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-01)Severe ulcerative colitis (UC) is a potentially life-threatening disease with a potential colorectal cancer (CRC) risk. The aim of this study was to explore the relationship between transcriptomic and genome-wide DNA methylation profiles in a well-stratified, treatment-naïve severe UC patient population in order to define specific epigenetic changes that could be responsible for the grade of disease ... -
DNA methylation and associated gene expression in blood prior to lung cancer diagnosis in the Norwegian Women and Cancer cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-13)The majority of lung cancer is caused by tobacco smoking, and lung cancer-relevant epigenetic markers have been identified in relation to smoking exposure. Still, smoking-related markers appear to mediate little of the effect of smoking on lung cancer. Thus in order to identify disease-relevant markers and enhance our understanding of pathways, a wide search is warranted. Through an epigenome-wide ... -
DNA methylation and copy number variation profiling of T-cell lymphoblastic leukemia and lymphoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-28)Despite having common overlapping immunophenotypic and morphological features, T-cell lymphoblastic leukemia (T-ALL) and lymphoma (T-LBL) have distinct clinical manifestations, which may represent separate diseases. We investigated and compared the epigenetic and genetic landscape of adult and pediatric T-ALL (<i>n</i> = 77) and T-LBL (<i>n</i> = 15) patient samples by high-resolution genome-wide ... -
DNA methylation changes measured in pre-diagnostic peripheral blood samples are associated with smoking and lung cancer risk
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-15)DNA methylation changes are associated with cigarette smoking. We used the Illumina Infinium HumanMethylation450 array to determine whether methylation in DNA from pre‐diagnostic, peripheral blood samples is associated with lung cancer risk. We used a case‐control study nested within the EPIC‐Italy cohort and a study within the MCCS cohort as discovery sets (a total of 552 case‐control pairs). We ... -
DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-05)<p><i>Background</i>: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL ... -
Dna methylation-based subtype prediction for pediatric acute lymphoblastic leukemia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-17)Background: We present a method that utilizes DNA methylation profiling for prediction of the cytogenetic subtypes of acute lymphoblastic leukemia (ALL) cells from pediatric ALL patients. The primary aim of our study was to improve risk stratification of ALL patients into treatment groups using DNA methylation as a complement to current diagnostic methods. A secondary aim was to gain insight into ... -
DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-28)Aim of the study: A vast majority of human malignancies are associated with ageing, and age is a strong predictor of cancer risk. Recently, DNA methylation-based marker of ageing, known as ‘epigenetic clock’, has been linked with cancer risk factors. This study aimed to evaluate whether the epigenetic clock is associated with breast cancer risk susceptibility and to identify potential epigenetics-based ... -
DNA over disk. En fremtidsstudie om bruken av hel-genom-sekvensering i Norge.
(Master thesis; Mastergradsoppgave, 2017-08-31)Genom-teknologien er et felt som på mange måter har gjenspeilet utviklingen på andre teknologiske områder. Hel-genom-tester (GWS = genome wide sequencing) har fått økt popularitet blant brukere i USA og ellers i verden til tross for at utviklingen av teknologien på dette området har tatt lengre tid enn først antatt. Det har vært debatt i media og kontroverser i forhold til myndighetenes forsøk på ... -
DNA uptake in mammalian cell cultures
(Mastergradsoppgave; Master thesis, 2009-07)Det har lenge vært hevdet at DNA som finnes i mat er innskrenket til, og blir hurtig degradert i fordøyelsessystemet til pattedyrene. Denne antagelsen har vist seg å være riktig for majoriteten av DNA i mat som går inn i fordøyelsessystemet, men mange studier har vist at denne degraderingen ikke skjer 100 %. DNA er et stabilt molekyl som kan overleve forholdene i fordøyelsessystemet, og herfra ... -
A DNA-Free Editing Platform for Genetic Screens in Soybean via CRISPR/Cas9 Ribonucleoprotein Delivery
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-12)CRISPR/Cas9-based ribonucleoprotein (RNP)-mediated system has the property of minimizing the effects related to the unwanted introduction of vector DNA and random integration of recombinant DNA. Here, we describe a platform based on the direct delivery of Cas9 RNPs to soybean protoplasts for genetic screens in knockout gene-edited soybean lines without the transfection of DNA vectors. The platform ... -
Do adolescents exposed to peer aggression at school consider themselves to be victims of bullying? The influence of sex and age
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-10)<p><b> Introduction</b> Exposure to peer aggression (PA) and bullying victimization (BV) are both expressions of peer victimization. <p><b> Objectives</b> In four age-sex groups, (1) Can exposure to PA and BV be considered distinct experiences? (2) To what extent do adolescents exposed to PA consider themselves bullying victims? and (3) What is the effect on BV of the number of PA events ... -
Do cancer patients with a poor prognosis use Complementary and Alternative Medicine more often than others?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2009)Introduction: One reason for patients with cancer to use complementary and alternative medicine (CAM) is that their cancer cannot be cured by conventional therapy. The aim of the present study is to explore whether use of CAM is associated with survival prognosis in long-term survivors of cancer. Materials and methods: Cancer patients who were alive 5 years or more after diagnosis were chosen to ... -
Do Cervical Cancer Patients Diagnosed with Opportunistic Screening Live Longer? An Arkhangelsk Cancer Registry Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-26)The aim of the current study was to compare cervical cancer (СС) patients diagnosed with and without screening in terms of: (i) sociodemographic and clinical characteristics; (ii) factors associated with survival; and (iii), and levels of risk. A registry-based study was conducted using data from the Arkhangelsk Cancer Registry. It included women with newly diagnosed malignant neoplasm of the uterine ...
